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SOD2/Mn-SOD Antibody [PE]

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Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
PE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB200-165AF350
Alexa Fluor 405
NB200-165AF405
Alexa Fluor 488
NB200-165AF488
Alexa Fluor 532
NB200-165AF532
Alexa Fluor 594
NB200-165AF594
Alexa Fluor 647
NB200-165AF647
Alexa Fluor 700
NB200-165AF700
Alexa Fluor 750
NB200-165AF750
Allophycocyanin
NB200-165APC
Biotin
NB200-165B
CoraFluor 1
NB200-165CL1
DyLight 350
NB200-165UV
DyLight 405
NB200-165V
DyLight 488
NB200-165G
DyLight 550
NB200-165R
DyLight 594
NB200-165DL594
DyLight 650
NB200-165C
DyLight 680
NB200-165FR
DyLight 755
NB200-165IR
FITC
NB200-165F
HRP
NB200-165H
Janelia Fluor 525
NB200-165JF525
Janelia Fluor 549
NB200-165JF549
Janelia Fluor 585
NB200-165JF585
Janelia Fluor 635
NB200-165JF635
Janelia Fluor 646
NB200-165JF646
Janelia Fluor 669
NB200-165JF669
PerCP
NB200-165PCP
Unconjugated
NB200-165
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SOD2/Mn-SOD Antibody [PE] Summary

Immunogen
A synthetic peptide between amino acids 175-222 of human manganese superoxide dismutase encoded within exon 5 (LocusLink ID 6648).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SOD2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for SOD2/Mn-SOD Antibody [PE]

  • EC 1.15.1.1
  • indophenoloxidase B
  • IPOB
  • IPO-B
  • manganese-containing superoxide dismutase
  • mangano-superoxide dismutase
  • Mn SOD
  • Mn superoxide dismutase
  • MnSOD
  • MVCD6
  • SOD, Mitochodrial
  • SOD2
  • superoxide dismutase [Mn], mitochondrial
  • superoxide dismutase 2, mitochondrial

Background

Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide (1, 2, 3). There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (CuZn SOD) and manganese-containing SOD (Mn SOD, SOD-2). The CuZn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from NFmediated apoptosis (4) via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria (6). Mn SOD has also been shown to be a tumor suppressor in human breast cancer (7). Overexpression of this enzyme protects neurons from NMDAand nitric oxide-induced neurotoxicity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SOD2/Mn-SOD
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NB200-165PE
SOD2/Mn-SOD Antibody [PE]
Species: Rt
Applications: WB

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Bioinformatics

Gene Symbol SOD2