SOD1/Cu-Zn SOD Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Superoxide Dismutases (SODs), originally identified as Indophenoloxidase (IPO), are enzymes that catalyze the converversion of naturally-occuring but harmful superoxide radicals into molecular oxygen and hydrogen peroxide. Superoxide Dismutases 1, SOD1, also known as Cu/Zn SOD, soluble SOD, and IPO-A, is a soluble, cytoplasmic 16 kDa homodimer. Each SOD1 monomer binds one Cu²⁺ and Zn²⁺ ion. Three isozymes of SOD have been identified and are functionally related but have very modest sequence homology. SOD1 shares 23% and 27% sequence identity with SOD2 and SOD3, respectively. Mutations in SOD1 have been suggested to be the cause of familial amyotrophic lateral sclerosis (ALS). The ALS-causing mutations of SOD1 are scattered throughout the protein and provide no clear functional or structural clues to the underlying disease mechanism. The oligomerization hypothesis suggests that mutant SOD1 proteins become misfolded and consequently oligomerize into high molecular weight aggregates that result in the death of motor neurons. The oxidative damage hypothesis suggests that loss of function mutations in SOD1 result in the intracellular accumulation of the superoxide radical, leading to free radical-mediated damage, the release of cytochrome c, and apoptosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Rat, Xenograft.

We have publications tested in 2 applications: Immunoassay, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF3418	Applications	Species
MF Pittenger, S Eghtesad, PG Sanchez, X Liu, Z Wu, L Chen, BP Griffith MSC Pretreatment for Improved Transplantation Viability Results in Improved Ventricular Function in Infarcted Hearts International Journal of Molecular Sciences, 2022-01-08;23(2):. 2022-01-08 [PMID: 35054878] (Western Blot, Rat)	Western Blot	Rat
Vuong Cat Khanh, Toshiharu Yamashita, Kinuko Ohneda, Chiho Tokunaga, Hideyuki Kato, Motoo Osaka et al. Rejuvenation of mesenchymal stem cells by extracellular vesicles inhibits the elevation of reactive oxygen species Scientific Reports 10/14/2020 [PMID: 33057147]
Maimaiti Yisireyili, Aziguli Alimujiang, Aikebaier Aili, Yiliang Li, Salamaiti Yisireyili, Kelimu Abudureyimu <p>Chronic Restraint Stress Induces Gastric Mucosal Inflammation with Enhanced Oxidative Stress in a Murine Model</p> Psychology Research and Behavior Management 5/4/2020 [PMID: 32440237]
A Langebäck, S Bacanu, H Laursen, L Mout, T Seki, S Erkens-Sch, AD Ramos, A Berggren, Y Cao, J Hartman, W van Weerde, J Bergh, P Nordlund, S Lööf CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance Sci Rep, 2019-12-18;9(1):19384. 2019-12-18 [PMID: 31852908] (Immunoassay, Human, Xenograft)	Immunoassay	Human, Xenograft
David Cruz-Garcia, Nathalie Brouwers, Juan M. Duran, Gabriel Mora, Amy J. Curwin, Vivek Malhotra A diacidic motif determines unconventional secretion of wild-type and ALS-linked mutant SOD1 Journal of Cell Biology 9/4/2017 [PMID: 28794127]
Kupershmidt L, Weinreb O, Amit T, Mandel S, Carri MT, Youdim MB Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis. FASEB J., 2009-07-28;23(11):3766-79. 2009-07-28 [PMID: 19638399] (Western Blot, Human)	Western Blot	Human

Array AF3418

• SOD1/Cu-Zn SOD Antibodies
• SOD1/Cu-Zn SOD Antibody Pair
• SOD1/Cu-Zn SOD ELISA Kits
• SOD1/Cu-Zn SOD Lysate
• SOD1/Cu-Zn SOD Proteins