Home » SHP-2/PTPN11 » SHP-2/PTPN11 Antibodies » SHP-2/PTPN11 Antibody (OTI3F2) [CoraFluor™ 1]
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SHP-2/PTPN11 Antibody (OTI3F2) [CoraFluor™ 1]

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Product Details

Summary
Reactivity Hu, Mu, Rt, CaSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
OTI3F2
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-74173AF350
Alexa Fluor 405
NBP2-74173AF405
Alexa Fluor 488
NBP2-74173AF488
Alexa Fluor 532
NBP2-74173AF532
Alexa Fluor 594
NBP2-74173AF594
Alexa Fluor 647
NBP2-74173AF647
Alexa Fluor 700
NBP2-74173AF700
Alexa Fluor 750
NBP2-74173AF750
Allophycocyanin
NBP2-74173APC
Biotin
NBP2-74173B
DyLight 350
NBP2-74173UV
DyLight 405
NBP2-74173V
DyLight 488
NBP2-74173G
DyLight 550
NBP2-74173R
DyLight 594
NBP2-74173DL594
DyLight 650
NBP2-74173C
DyLight 680
NBP2-74173FR
DyLight 755
NBP2-74173IR
FITC
NBP2-74173F
HRP
NBP2-74173H
Janelia Fluor 525
NBP2-74173JF525
Janelia Fluor 549
NBP2-74173JF549
Janelia Fluor 646
NBP2-74173JF646
Janelia Fluor 669
NBP2-74173JF669
PE
NBP2-74173PE
PerCP
NBP2-74173PCP
Unconjugated
NBP2-03063
mFluor Violet 450 SE
NBP2-74173MFV450
mFluor Violet 500 SE
NBP2-74173MFV500
mFluor Violet 610 SE
NBP2-74173MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-03063
Azide and BSA Free
NBP2-74173
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SHP-2/PTPN11 Antibody (OTI3F2) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
Full length human recombinant protein of human PTPN11(NP_002825) produced in HEK293T cell.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
PTPN11
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for SHP-2/PTPN11 Antibody (OTI3F2) [CoraFluor™ 1]

  • BPTP3
  • EC 3.1.3.48
  • MGC14433
  • protein tyrosine phosphatase, non-receptor type 11
  • protein tyrosine phosphatase-2
  • Protein-tyrosine phosphatase 1D
  • Protein-tyrosine phosphatase 2C
  • PTP1D
  • PTP-1D
  • PTP2C
  • PTP-2C
  • PTP2CNS1
  • PTPN11
  • SHP2
  • SHP-2
  • SHP2CFC
  • SHPTP2
  • SH-PTP2
  • SH-PTP2Noonan syndrome 1
  • SH-PTP3
  • tyrosine-protein phosphatase non-receptor type 11

Background

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SHP-2/PTPN11 Antibody (OTI3F2) [CoraFluor™ 1]
Species: Hu, Mu, Rt, Ca
Applications: WB, Flow, CyTOF-ready

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Bioinformatics

Gene Symbol PTPN11