Raf-1 Antibody (563002) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Raf serine/threonine kinases are effectors of Ras that function as MAP3Ks in the ERK phosphorylation cascade. Mammals express three Raf proteins: A-Raf, B-Raf, and Raf-1, also known as C-Raf. Human Raf-1 contains three distinct regions; an N-terminal RBD (Ras-binding domain) (aa 56 - 131), followed by two rich segments [a cysteine-finger region (aa 138 - 184) (also called CR1/C1) and a second cysteine-rich region (CR2) (aa 253 - 264)] and a C-terminal Ser/Thr kinase catalytic domain (aa 354 - 611). Active Raf-1 phosphorylates and activates the MAPK kinases MEK1 and 2, which in turn phosphorylate and activate the MAP kinases ERK1 and 2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB4540	Applications	Species
Dongsic Choi, Laura Montermini, Brian Meehan, Anthoula Lazaris, Peter Metrakos, Janusz Rak Oncogenic RAS drives the CRAF‐dependent extracellular vesicle uptake mechanism coupled with metastasis Journal of Extracellular Vesicles 2021-06-10 [PMID: 34136107]
F Gallardo, B Mariamé, R Gence, AF Tilkin-Mar Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth Drug Des Devel Ther, 2018-09-07;12(0):2805-2814. 2018-09-07 [PMID: 30233143] (Western Blot, Human)	Western Blot	Human

Array MAB4540

• Raf-1 Antibodies
• Raf-1 ELISA Kits
• Raf-1 Lysate
• Raf-1 Protein
• Raf-1 Proteins and Enzyme