Serpin E1/PAI-1 Antibody

PAI-1 and PAI-2 (for plasminogen activator inhibitor-1 and -2) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 have been shown to regulate uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage, resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. uPA is a serine proteinase that is a member of the trypsin family. It is responsible for the cleavage of plasminogen at the Arg-Val bond to produce plasmin. uPA consists of two chains designated A and B. The A chain can be cleaved, resulting in low and high molecular mass forms of uPA.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 3 of 3.

Publications using NBP2-13298	Applications	Species
Lemaire R, Burwell T, Sun H et al. Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1. Arthritis Rheumatol 2016-02-01 [PMID: 26414805]
Rice LM, Padilla CM, McLaughlin SR et al. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest 2015-07-01 [PMID: 26098215] (Human)		Human
Zhang G, Gomes-Giacoia E, Dai Y et al. Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature. Diagn Pathol 2014-11-12 [PMID: 25387487] (IF/IHC, Human)	IF/IHC	Human

Array NBP2-13298

• Serpin E1/PAI-1 Antibodies
• Serpin E1/PAI-1 Antibody Pair
• Serpin E1/PAI-1 ELISA Kits
• Serpin E1/PAI-1 Lysate
• Serpin E1/PAI-1 Proteins
• Serpin E1/PAI-1 ELISAs
• Serpin E1/PAI-1 Proteins and Enzyme