Recombinant Rat Neurofascin Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neurofascin, a type I transmembrane glycoprotein, is a member of the L1 family of cell adhesion molecules (CAMs) (1-4). L1CAM family members are composed of an extracellular domain (ECD) that contains six immunoglobulin (Ig)-like domains and multiple fibronectin type III repeats, followed by transmembrane and cytoplasmic domains (2, 4, 5). Multiple isoforms of Neurofascin, including NF155, NF166, NF180, and NF186, can be generated by alternative splicing that differ in the combination of fibronectin type III repeats, as well as in the presence of a proline-, alanine-, and threonine-rich segment (PAT domain) located just after the fourth fibronectin type III repeat (4). This recombinant rat Neurofascin protein corresponds to isoform NF155 and shares 98% amino acid sequence identity with comparable regions of human and mouse Neurofascin. In rats, NF155 is transiently expressed by oligodendrocytes and Schwann cells during axon myelination (6, 7). NF155 clusters in paranodal regions of oligodendroglia and binds to the Caspr-Contactin complex located on the adjacent axon to form and stabilize paranodal axoglial junctions (8-11). It has been suggested that the ECD of NF155 must be cleaved from oligodendroglia membranes to form and/or stabilize the paranodal structure (12). NF155 has also been shown to promote neuronal adhesion and neurite outgrowth in rats and chickens (12-14). Alterations in NF155 expression have been associated with multiple sclerosis (15).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, ELISA (Capture).

Showing Publications 1 - 3 of 3.

Publications using 3235-NF	Applications	Species
Katsunori Ikewaki IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay J. Neuroimmunol., 2016-11-09;0(0):. 2016-11-09 [PMID: 27852440] (Bioassay)	Bioassay
Pruss H, Schwab JM, Derst C, Gortzen A, Veh RW Neurofascin as target of autoantibodies in Guillain-Barre syndrome. Brain, 2011-01-27;134(0):e173; author . 2011-01-27 [PMID: 21278083] (ELISA (Capture), Human)	ELISA (Capture)	Human
Mathey EK, Derfuss T, Storch MK, Williams KR, Hales K, Woolley DR, Al-Hayani A, Davies SN, Rasband MN, Olsson T, Moldenhauer A, Velhin S, Hohlfeld R, Meinl E, Linington C Neurofascin as a novel target for autoantibody-mediated axonal injury. J. Exp. Med., 2007-09-10;204(10):2363-72. 2007-09-10 [PMID: 17846150] (ELISA (Capture), Human)	ELISA (Capture)	Human

Array 3235-NF

• Neurofascin Antibodies
• Neurofascin ELISA Kits
• Neurofascin Protein
• Neurofascin Proteins and Enzymes