Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Programmed Death Ligand 2 (PD-L2), also known as B7-DC and butyrophilin-like protein, is a member of the B7 family of proteins that provide signals for regulating T-cell activation and tolerance (1). Mature mouse PD-L2 consists of a 199 amino acid (aa) extracellular domain (ECD) with one V-like and one C-like Ig domain, a 23 aa transmembrane segment, and a 5 aa cytoplasmic domain (2, 3). Within the ECD, mouse and human PD-L2 share 72% aa sequence identity. PD-L2 is expressed on dendritic cells, subsets of activated CD4⁺ and CD8⁺ T cells, and memory B cells that differentiate into plasma cells (3-5). At inflammatory sites such as rheumatoid arthritis, allergen exposure, and virus infection, PD-L2 is up-regulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells (6-10).
PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand up-regulation while inhibiting IL-4 production (2, 3, 11, 12). In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance (13). In asthma, PD-L2 suppresses IL-5 and
IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production (8, 10).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, ELISA (Capture), In Vivo, Surface Plasmon Resonance.

Showing Publications 1 - 4 of 4.

Publications using 1022-PL	Applications	Species
BP Hurrell, DG Helou, E Howard, JD Painter, P Shafiei-Ja, AH Sharpe, O Akbari PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability Nature Communications, 2022-08-31;13(1):5118. 2022-08-31 [PMID: 36045140] (Bioassay, Mouse)	Bioassay	Mouse
LP Garo, AK Ajay, M Fujiwara, V Beynon, C Kuhn, G Gabriely, S Sadhukan, R Raheja, S Rubino, HL Weiner, G Murugaiyan Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity Cell Rep, 2019-09-24;28(13):3353-3366.e5. 2019-09-24 [PMID: 31553906] (In Vivo, Mouse)	In Vivo	Mouse
Xiao , Yanping, Yu , Sanhong, Zhu , Baogong, Bedoret , Denis, Bu , Xia, Francisco , Loise M, Hua , Ping, Duke-Cohan , Jonathan, Umetsu , Dale T, Sharpe , Arlene H, DeKruyff , Rosemari, Freeman , Gordon J RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med, 2014-04-21;211(5):943-59. 2014-04-21 [PMID: 24752301] (ELISA (Capture), Mouse)	ELISA (Capture)	Mouse
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity, 2007-07-12;27(1):111-22. 2007-07-12 [PMID: 17629517] (Surface Plasmon Resonance)	Surface Plasmon Resonance

Array 1022-PL

• PD-L2/B7-DC/PDCD1LG2 Antibodies
• PD-L2/B7-DC/PDCD1LG2 Antibody Pair
• PD-L2/B7-DC/PDCD1LG2 Lysate
• PD-L2/B7-DC/PDCD1LG2 Proteins
• PD-L2/B7-DC/PDCD1LG2 Proteins and Enzymes
• PD-L2/B7-DC/PDCD1LG2 ELISA