Recombinant Mouse PD-1 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Programmed Death-1 receptor (PD-1), also known as CD279, is type I transmembrane protein belonging to the CD28 family of immune regulatory receptors (1). Other members of this family include CD28, CTLA-4, ICOS, and BTLA (2-5). Mature mouse PD-1 consists of a 149 amino acid (aa) extracellular region (ECD) with one immunoglobulin-like V-type domain, a 21 aa transmembrane domain, and a 98 aa cytoplasmic region. The mouse PD-1 ECD shares 65% aa sequence identity with the human PD-1 ECD. The cytoplasmic tail contains two tyrosine residues that form the immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) that are important for mediating PD-1 signaling. PD-1 acts as a monomeric receptor and interacts in a 1:1 stoichiometric ratio with its ligands PD-L1 (B7-H1) and PD-L2 (B7-DC) (6, 7). PD‑1 is expressed on activated T cells, B cells, monocytes, and dendritic cells while PD-L1 expression is constitutive on the same cells and also on nonhematopoietic cells such as lung endothelial cells and hepatocytes (8, 9). Ligation of PD-L1 with PD-1 induces
co-inhibitory signals on T cells promoting their apoptosis, anergy, and functional exhaustion (10). Thus, the PD-1:PD-L1 interaction is a key regulator of the threshold of immune response and peripheral immune tolerance (11). Finally, blockade of the PD-1: PD-L1 interaction by either antibodies or genetic manipulation accelerates tumor eradication and shows potential for improving cancer immunotherapy (12, 13).

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: Bioassay, ELISA Capture, ELISA Standard, Enzyme Assay, Flow Cytometry, Surface Plasmon Resonance.

Showing Publications 1 - 8 of 8.

Publications using 1021-PD	Applications	Species
A Mehdi, M Attias, A Arakelian, CA Piccirillo, M Szyf, SA Rabbani Co-Targeting Luminal B Breast Cancer with S-Adenosylmethionine and Immune Checkpoint Inhibitor Reduces Primary Tumor Growth and Progression, and Metastasis to Lungs and Bone Cancers, 2022-12-22;15(1):. 2022-12-22 [PMID: 36612044] (Bioassay, Mouse)	Bioassay	Mouse
CJ Edwards, A Sette, C Cox, B Di Fiore, C Wyre, D Sydoruk, D Yadin, P Hayes, S Stelter, PD Bartlett, M Zuazo, MJ Garcia-Gra, G Benedetti, S Fiaska, NR Birkett, Y Teng, C Enever, H Arasanz, A Bocanegra, L Chocarro, G Fernandez, R Vera, B Archer, I Osuch, M Lewandowsk, YM Surani, G Kochan, D Escors, J Legg, AJ Pierce The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity British Journal of Cancer, 2021-12-30;0(0):. 2021-12-30 [PMID: 34969998] (Bioassay, Mouse)	Bioassay	Mouse
J Guiteras, L De Ramon, E Crespo, N Bolaños, S Barcelo-Ba, L Martinez-V, P Fontova, M Jarque, A Torija, O Bestard, D Resina, JM Grinyó, J Torras Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models International Journal of Molecular Sciences, 2021-01-26;22(3):. 2021-01-26 [PMID: 33530581] (Surface Plasmon Resonance, Rat)	Surface Plasmon Resonance	Rat
N Silva-Pili, E Martisova, MC Ballestero, S Hervas-Stu, N Casares, G González-S, C Smerdou, L Vanrell Long-Term Systemic Expression of a Novel PD-1 Blocking Nanobody from an AAV Vector Provides Antitumor Activity without Toxicity Biomedicines, 2020-12-02;8(12):. 2020-12-02 [PMID: 33276580] (Bioassay, ELISA Capture, Human)	Bioassay, ELISA Capture	Human
L Jacobs, E De Smidt, N Geukens, P Declerck, K Hollevoet DNA-Based Delivery of Checkpoint Inhibitors in Muscle and Tumor Enables Long-Term Responses with Distinct Exposure Mol. Ther., 2020-02-13;0(0):. 2020-02-13 [PMID: 32101701] (ELISA Standard, Mouse)	ELISA Standard	Mouse
Matsumura , Takuhiro, Sugawara , Yo, Yutani , Masahiro, Amatsu , Sho, Yagita , Hideo, Kohda , Tomoko, Fukuoka , Shin-Ich, Nakamura , Yutaka, Fukuda , Shinji, Hase , Koji, Ohno , Hiroshi, Fujinaga , Yukako Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity. Nat Commun, 2015-02-17;6(0):6255. 2015-02-17 [PMID: 25687350] (Enzyme Assay, Mouse)	Enzyme Assay	Mouse
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity, 2007-07-12;27(1):111-22. 2007-07-12 [PMID: 17629517] (Bioassay, Mouse)	Bioassay	Mouse
Arnett HA, Escobar SS, Gonzalez-Suarez E, Budelsky AL, Steffen LA, Boiani N, Zhang M, Siu G, Brewer AW, Viney JL BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation. J. Immunol., 2007-02-01;178(3):1523-33. 2007-02-01 [PMID: 17237401] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array 1021-PD

• PD-1 Antibodies
• PD-1 Antibody Pair
• PD-1 Lysate
• PD-1 Proteins
• PD-1 Proteins and Enzymes
• PD-1 ELISAs