Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

OX40 (CD134; TNFRSF4) is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response (1-3). Mouse OX40 cDNA encodes a 256 amino acid (aa) type I transmembrane glycoprotein with a 19 aa signal sequence, a 192 aa extracellular domain (ECD) that contains a cysteine-rich region, a 25 aa transmembrane segment, and a 36 aa cytoplasmic domain (4). The ECD of mouse OX40 shares 90% and 63% sequence identity with the ECD of rat and human OX40, respectively. OX40 is up-regulated on CD4⁺ and CD8⁺ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7 (5, 6). OX40 Ligand is primarily expressed on antigen presenting cells (5). OX40 Ligand engagement of OX40 on activated CD4⁺ T cells results in increased T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into immunosuppressive regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells (3, 7-10). OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. OX40 has also been shown to decrease the cells’ immunosuppressive activity on effector T cells (11-14). OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease (6, 15, 16). Mutations in OX40 and OX40 Ligand are associated with cardiovascular disease (17, 18).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Bioassay, In Vivo, mAb Generation.

Showing Publications 1 - 3 of 3.

Publications using 1256-OX	Applications	Species
P Zhang, GH Tu, J Wei, P Santiago, LR Larrabee, S Liao-Chan, T Mistry, ML Chu, T Sai, K Lindquist, H Long, J Chaparro-R, S Salek-Arda, YA Yeung Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity Cell Rep, 2019-06-11;27(11):3117-3123.e5. 2019-06-11 [PMID: 31189099] (mAb Generation, Mouse)	mAb Generation	Mouse
G Sun, H Jin, C Zhang, H Meng, X Zhao, D Wei, X Ou, Q Wang, S Li, T Wang, X Sun, W Shi, D Tian, K Liu, H Xu, Y Tian, X Li, W Guo, J Jia, Z Zhang, D Zhang OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis Cell Rep, 2018-12-26;25(13):3786-3799.e4. 2018-12-26 [PMID: 30590049] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Dollins CM, Nair S, Boczkowski D, Lee J, Layzer JM, Gilboa E, Sullenger BA Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. Chem. Biol., 2008-07-21;15(7):675-82. 2008-07-21 [PMID: 18635004] (Bioassay, Mouse)	Bioassay	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Binding assay/Protein-protein interaction		11/16/2018	View Summary Application Binding assay/Protein-protein interaction Lot GDO0217011

Array 1256-OX

• OX40/TNFRSF4 Antibodies
• OX40/TNFRSF4 ELISA Kit
• OX40/TNFRSF4 Lysate
• OX40/TNFRSF4 ELISA
• OX40/TNFRSF4 Proteins and Enzymes