Recombinant Mouse Lumican Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lumican is a 40 kDa member of the family of small leucine-rich repeat proteoglycans (SLRPs) and the class II subfamily (1). Mouse Lumican is synthesized as a 338 amino acid (aa) precursor that contains an 18 aa signal sequence and a 320 aa mature chain (SwissProt #: 51885). The mature chain contains a negatively charged N-terminal domain containing sulfated tyrosine and disulfide bonds, 12 leucine-rich repeats (LRRs), four potential sites of N-linked glycosylation, and a carboxyl terminal domain containing two conserved cysteines (1). Mature mouse Lumican is 98%, 88%, and 70% aa identical to mature rat, human, and chick Lumican, respectively. SLRPs constitute an important fraction of noncollagenous extracellular matrix proteins (ECM) proteins (1, 2). Lumican is expressed in a variety of tissues, including skin, artery, lung, cornea, kidney, bone, aorta, and articular cartilage (1). Lumican’s role in vivo has been found using Lumican null mice. These mice have functional deficits including corneal opacity as well as skin and tendon fragility associated with disorganized and loosely packed collagen fibers (1, 3-6). The abnormal connective tissue phenotype seen in the Lumican null mice shows the importance of the role of Lumican in collagen fibrillogenesis (1). In addition to the control of collagen fibril assembly, Lumican has been shown to play a role in the regulation of cell proliferation (7, 8), migration (8 - 9), and adhesion (9). Lumican’s overexpression has been reported in carcinoid tumor, breast, colorectal, neuroendocrine, uterine cervical and pancreatic cancers (10).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, Enzyme Assay Substrate.

Showing Publications 1 - 5 of 5.

Publications using 2745-LU	Applications	Species
López-Alcalá, J;Soler-Vázquez, MC;Tercero-Alcázar, C;Sánchez-Ceinos, J;Guzmán-Ruiz, R;Malagón, MM;Gordon, A; Rab18 Drift in Lipid Droplet and Endoplasmic Reticulum Interactions of Adipocytes under Obesogenic Conditions International journal of molecular sciences 2023-12-06 [PMID: 38139006] (Bioassay, Mouse)	Bioassay	Mouse
HJ Cho, YS Lee, DA Kim, SA Moon, SE Lee, SH Lee, JM Koh Lumican, an Exerkine, Protects against Skeletal Muscle Loss International Journal of Molecular Sciences, 2022-09-02;23(17):. 2022-09-02 [PMID: 36077426] (Bioassay, Mouse)	Bioassay	Mouse
AF Asega, MC Menezes, D Trevisan-S, D Cajado-Car, L Bertholim, AK Oliveira, A Zelanis, SMT Serrano Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases Sci Rep, 2020-07-31;10(1):12912. 2020-07-31 [PMID: 32737331] (Bioassay, Mouse)	Bioassay	Mouse
X Li, Y Kang, D Roife, Y Lee, M Pratt, MR Perez, B Dai, EJ Koay, JB Fleming Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth Oncogene, 2017-05-22;0(0):. 2017-05-22 [PMID: 28534517] (Bioassay, Mouse)	Bioassay	Mouse
Yu Y, Hoffhines AJ, Moore KL, Leary JA Determination of the sites of tyrosine O-sulfation in peptides and proteins. Nat. Methods, 2007-06-10;4(7):583-8. 2007-06-10 [PMID: 17558413] (Enzyme Assay Substrate, Mouse)	Enzyme Assay Substrate	Mouse

Array 2745-LU

• Lumican Antibodies
• Lumican ELISA Kit
• Lumican Lysate
• Lumican Protein
• Lumican Proteins and Enzymes
• Lumican ELISA