Recombinant Mouse Galectin-3 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain (1, 2). Mature mouse Galectin-3 shares 80% and 86% amino acid (aa) sequence identity with human and rat Galectin-3, respectively. Galectin-3 is a 26 kDa protein that can be nuclear, cytoplasmic, or secreted (3, 4). Nuclear Galectin-3 can modulate gene expression, while cytosolic Galectin-3 can inhibit apoptosis and can participate in exocytosis, Caveolin-mediated endocytosis, and macrophage-mediated clearance of apoptotic cells (5-7). Extracellular Galectin-3 has been shown to form high-order oligomers that promote the cross-linking of cell surface oligosacchraides as well as integrin-dependent cell adhesion and apoptosis (8-11). Galectin-3 contributes to the innate immune response against Candida albicans and Streptococcus pneumoniae, and it can facilitate acute inflammatory responses via neutrophil activation and opsonization, macrophage recruitment, and mast cell activation (12-14). Galectin-3 can also contribute to chronic inflammation and fibrosis (15). It is implicated in neuroinflammatory disorders of the central nervous system, cardiac fibrosis, and heart failure, as well as tumor growth, progression, and metastasis (16-18).

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 7 of 7.

Publications using 1197-GA/CF	Applications	Species
C Bülck, EEL Nyström, T Koudelka, M Mannbar-Fr, G Andresen, M Radhouani, F Tran, F Scharfenbe, F Schrell, F Armbrust, E Dahlke, B Zhao, A Vervaeke, F Theilig, P Rosenstiel, P Starkl, SP Rosshart, H Fickensche, A Tholey, GC Hansson, C Becker-Pau Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis Science Advances, 2023-03-31;9(13):eadf4055. 2023-03-31 [PMID: 37000885] (Bioassay, Human)	Bioassay	Human
NJ Esposito, F Mazzoni, JA Vargas, SC Finnemann Diurnal Photoreceptor Outer Segment Renewal in Mice Is Independent of Galectin-3 Investigative Ophthalmology & Visual Science, 2021-02-01;62(2):7. 2021-02-01 [PMID: 33538769] (Bioassay, Porcine)	Bioassay	Porcine
Jia W, Kidoya H, Yamakawa D, Naito H, Takakura N Galectin-3 accelerates M2 macrophage infiltration and angiogenesis in tumors. Am J Pathol, 2013-03-13;182(5):1821-31. 2013-03-13 [PMID: 23499465] (Bioassay, Mouse)	Bioassay	Mouse
Mackinnon , Alison C, Liu , Xiaojun, Hadoke , Patrick, Miller , Mark R, Newby , David E, Sethi , Tariq Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice. Glycobiology, 2013-02-19;23(6):654-63. 2013-02-19 [PMID: 23426722] (Bioassay, Mouse)	Bioassay	Mouse
Li Y, Komai-Koma M, Gilchrist DS, Hsu DK, Liu FT, Springall T, Xu D Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation. J. Immunol., 2008-08-15;181(4):2781-9. 2008-08-15 [PMID: 18684969] (Bioassay)	Bioassay
Silva-Monteiro E, Reis Lorenzato L, Kenji Nihei O, Junqueira M, Rabinovich GA, Hsu DK, Liu FT, Savino W, Chammas R, Villa-Verde DM Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection. Am. J. Pathol., 2007-02-01;170(2):546-56. 2007-02-01 [PMID: 17255323] (Bioassay, Mouse)	Bioassay	Mouse
He J, Baum LG Presentation of galectin-1 by extracellular matrix triggers T cell death. J. Biol. Chem., 2003-11-14;279(6):4705-12. 2003-11-14 [PMID: 14617626] (Bioassay, Human)	Bioassay	Human

Array 1197-GA/CF

• Galectin-3 Antibodies
• Galectin-3 Antibody Pair
• Galectin-3 ELISA Kits
• Galectin-3 Lysate
• Galectin-3 Proteins
• Galectin-3 ELISAs
• Galectin-3 Proteins and Enzymes