Recombinant Mouse Brevican Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Brevican, also called BEHAB, is a member of the the lectican family of proteoglycans that share a common domain structure (1). It is restricted to the CNS and associates with perineuronal nets and astrocytes (2 ‑ 5). Brevican contains an Ig-like V-set domain, two link domains, a Glu-rich region, a central region with glycosaminoglycan (GAG) modifications, an EGF-like domain, a C-type lectin domain, and a C-terminal Sushi/CRP-like domain (6). Brevican consists of a 145 kDa core protein with up to approximately 100 kDa of attached chondroitin sulfate but not heparan sulfate chains (3, 7). Alternate splicing generates a GPI-anchored isoform that lacks the EGF-like, lectin, and Sushi domains (4, 6). Brevican is cleaved by multiple proteases and exists in a number of distinct fragments (8, 9). An under-glycosylated form of Brevican accumulates in highly aggressive glioma, Alzheimer’s-like brain, and following brain injury (10 - 12). Levels of an ADAMTS-generated 55 kDa N-terminal fragment accumulate during remodeling after excitotoxic injury, and Brevican cleavage is required for its ability to promote glioma adhesion and motility (13 ‑ 15). In contrast, Brevican cleavage is inhibited in mouse brain with amyloid beta deposits (10). Mouse Brevican shares 80%, 81%, and 95% aa sequence identity with bovine, human, and rat Brevican, respectively. Within the Ig-like and two link domains, mouse Brevican shares 47% - 51% aa sequence identity with mouse Aggrecan, Neurocan, and Versican.

Array 7188-BC

• Brevican Antibodies
• Brevican ELISA Kit
• Brevican Lysate
• Brevican Protein
• Brevican Proteins and Enzymes