Recombinant Mouse Axl Fc Chimera (CHO-expressed) Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. TAM family receptors (Dtk/Tyro3, Axl, and Mer) are involved in regulation of the inflammatory response, cell survival and migration, and tumorigenesis (1). Mature mouse Axl consists of a 427 aa extracellular domain (ECD) that contains two Ig-like domains and two fibronectin type III domains, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain that includes the tyrosine kinase domain (2, 3). Within the ECD, mouse Axl shares 81% and 95% aa sequence identity with human and rat Axl, respectively. Axl binds the vitamin K‑dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain (4). Activation of Axl induces a broad range of activities including platelet aggregation and thrombus formation (5), macrophage and dendritic cell phagocytosis of apoptotic cells (6), NK cell development from hematopoietic progenitor cells (7), and in vivo angiogenesis (8). Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness (8, 9). It contributes to vascular remodeling and inflammatory cell infiltration in response to hypertension and restricted blood flow (10). It also functions as a cellular entry receptor for Gas6‑opsonized lentiviruses (11). A 70‑80 kDa soluble portion of the Axl ECD can be shed by proteolytic cleavage, and this fragment retains the ability to bind Gas6 (12, 13).

Array 7477-AX

• Axl Antibodies
• Axl Antibody Pair
• Axl Lysate
• Axl Proteins
• Axl ELISAs
• Axl Proteins and Enzymes