Recombinant Human Gas6 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Gas6 (Growth Arrest Specific 6) is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest (1). Gas6 and the structurally related Protein S are vitamin K-dependent and have an extensively gamma -carboxylated N-terminal Gla domain, four EGF-like repeats, and a C-terminal region with homology to steroid hormone binding globulin (SHBG) (2). Human Gas6 is a 75 kDa protein that shares 77%-79% aa sequence identity with mouse and rat Gas6, and 43% aa identity with human protein S (over the region expressed). Alternate splicing generates isoforms that lack the Gla domain and/or the spacer between the
EGF‑like and SHBG regions. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer (3-5). Human Gas6 interacts with both mouse and rat orthologs of these receptors (1). The full length isoform may be cleaved, resulting in release of the free SHBG region which can independently activate Axl (6). Shed soluble forms of Axl and Mer bind Gas6 and function as decoy receptors (7, 8). Gas6 induces a variety of responses, including prevention of apoptosis (9), cell proliferation (10), platelet-mediated thrombosis (11), retinal epithelial cell phagocytosis of outer rod segments (12), inhibition of VEGF-induced endothelial cell chemotaxis (13), and the differentiation and expansion of NK cell precursors (14). The affinity of Gas6 for phosphatidylserine likely contributes to its role in promoting the phagocytosis of apoptotic cells (15). Several of these effects have been shown to require gamma -carboxylation of the Gla domain (12, 16).

We have publications tested in 5 confirmed species: Human, Mouse, N/A, Transgenic Mouse, Xenopus.

We have publications tested in 9 applications: Activation, Bioassay, Cell Culture, ELISA (Capture), ELISA (Standard), ELISA Standard, Flow Cytometry, In Vivo, Western Blot.

Showing Publications 1 - 10 of 38. Show All 38 Publications. Collapse Publications.

Publications using 885-GSB	Applications	Species
Demirsoy, S;Tran, H;Liu, J;Li, Y;Yang, S;Aregawi, D;Glantz, MJ;Jacob, NK;Walter, V;Schell, TD;Olmez, I; Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 Inhibition Cancers 2024-06-18 [PMID: 38927958] (Bioassay, Human)	Bioassay	Human
Lahey, KC;Varsanyi, C;Wang, Z;Aquib, A;Gadiyar, V;Rodrigues, AA;Pulica, R;Desind, S;Davra, V;Calianese, DC;Liu, D;Cho, JH;Kotenko, SV;De Lorenzo, MS;Birge, RB; Regulation of Mertk Surface Expression via ADAM17 and ?-Secretase Proteolytic Processing International journal of molecular sciences 2024-04-17 [PMID: 38673989] (Western Blot, N/A)	Western Blot	N/A
Lundquist, MR;Jaffrey, SR; Gas6-Axl Signaling Induces SRF/MRTF-A Gene Transcription via MICAL2 Genes 2023-12-18 [PMID: 38137053] (Bioassay, Human)	Bioassay	Human
Nguyen, LT;Aprico, A;Nwoke, E;Walsh, AD;Blades, F;Avneri, R;Martin, E;Zalc, B;Kilpatrick, TJ;Binder, MD; Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS Journal of neuroinflammation 2023-11-06 [PMID: 37926818] (Bioassay, In Vivo, Xenopus, Transgenic Mouse)	Bioassay, In Vivo	Xenopus, Transgenic Mouse
Serwe, G;Kachaner, D;Gagnon, J;Plutoni, C;Lajoie, D;Duramé, E;Sahmi, M;Garrido, D;Lefrançois, M;Arseneault, G;Saba-El-Leil, MK;Meloche, S;Emery, G;Therrien, M; CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling Nature communications 2023-06-15 [PMID: 37322019] (Bioassay, Human)	Bioassay	Human
Tsugawa, H;Ohki, T;Tsubaki, S;Tanaka, R;Matsuzaki, J;Suzuki, H;Hozumi, K; Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver PLoS pathogens 2023-06-01 [PMID: 37289655] (Bioassay, Human)	Bioassay	Human
Hedrich, V;Breitenecker, K;Ortmayr, G;Pupp, F;Huber, H;Chen, D;Sahoo, S;Jolly, MK;Mikulits, W; PRAME Is a Novel Target of Tumor-Intrinsic Gas6/Axl Activation and Promotes Cancer Cell Invasion in Hepatocellular Carcinoma Cancers 2023-04-22 [PMID: 37173882] (Bioassay, Human)	Bioassay	Human
J Kim, G Nam, YK Shin, N Vilaplana-, HC Jeung, EJ Moon, IJ Lee Targeting AXL Using the AVB-500 Soluble Receptor and through Genetic Knockdown Inhibits Bile Duct Cancer Growth and Metastasis Cancers, 2023-03-21;15(6):. 2023-03-21 [PMID: 36980768] (Bioassay, Human)	Bioassay	Human
M Iida, NK McDaniel, KL Kostecki, NB Welke, CA Kranjac, P Liu, C Longhurst, JY Bruce, S Hong, R Salgia, DL Wheeler AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer BMC Cancer, 2022-04-23;22(1):447. 2022-04-23 [PMID: 35461210] (Bioassay, Human)	Bioassay	Human
A Puddu, S Ravera, I Panfoli, N Bertola, D Maggi High Glucose Impairs Expression and Activation of MerTK in ARPE-19 Cells International Journal of Molecular Sciences, 2022-01-20;23(3):. 2022-01-20 [PMID: 35163068] (Bioassay, Human)	Bioassay	Human
LW Sun, SH Kao, SF Yang, SW Jhang, YC Lin, CM Chen, YH Hsieh Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis Cells, 2021-10-28;10(11):. 2021-10-28 [PMID: 34831142] (Bioassay, Human)	Bioassay	Human
H Chang, R An, X Li, X Lang, J Feng, M Lv Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cells Oncology Letters, 2021-08-27;22(5):749. 2021-08-27 [PMID: 34539853] (Bioassay, ELISA (Capture), Human)	Bioassay, ELISA (Capture)	Human
X Wu, L Wang, NA Pearson, S Renuse, R Cheng, Y Liang, DG Mun, AK Madugundu, Y Xu, PS Gill, A Pandey Quantitative Tyrosine Phosphoproteome Profiling of AXL Receptor Tyrosine Kinase Signaling Network Cancers, 2021-08-23;13(16):. 2021-08-23 [PMID: 34439388] (Bioassay, Human)	Bioassay	Human
S Pietrobono, G Anichini, C Sala, F Manetti, LL Almada, S Pepe, RM Carr, BD Paradise, JN Sarkaria, JI Davila, L Tofani, I Battisti, G Arrigoni, L Ying, C Zhang, H Li, A Meves, ME Fernandez-, B Stecca ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL Nat Commun, 2020-11-17;11(1):5865. 2020-11-17 [PMID: 33203881] (Bioassay, Human)	Bioassay	Human
W Du, J Zhu, Y Zeng, T Liu, Y Zhang, T Cai, Y Fu, W Zhang, R Zhang, Z Liu, JA Huang KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway Cell Death Differ, 2020-11-02;0(0):. 2020-11-02 [PMID: 33139930] (Bioassay, Human)	Bioassay	Human
J Xue, L Xu, H Zhu, M Bai, X Li, Z Zhao, H Zhong, G Cheng, X Li, F Hu, Y Su CD14+CD16- monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK Arthritis Research & Therapy, 2020-09-21;22(1):221. 2020-09-21 [PMID: 32958023] (Bioassay, Human)	Bioassay	Human
A Abu-Thurai, MA Goyette, J Boulais, C Delliaux, C Apcher, C Schott, R Chidiac, H Bagci, MP Thibault, D Davidson, M Ferron, A Veillette, RJ Daly, AC Gingras, JP Gratton, JF Côté AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network Nat Commun, 2020-07-17;11(1):3586. 2020-07-17 [PMID: 32681075] (ELISA Standard, Human)	ELISA Standard	Human
S Alivernini, L MacDonald, A Elmesmari, S Finlay, B Tolusso, MR Gigante, L Petricca, C Di Mario, L Bui, S Perniola, M Attar, M Gessi, AL Fedele, S Chilaka, D Somma, SN Sansom, A Filer, C McSharry, NL Millar, K Kirschner, A Nerviani, MJ Lewis, C Pitzalis, AR Clark, G Ferracciol, I Udalova, CD Buckley, E Gremese, IB McInnes, TD Otto, M Kurowska-S Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis Nat. Med., 2020-06-29;0(0):. 2020-06-29 [PMID: 32601335] (Flow Cytometry, Human)	Flow Cytometry	Human
T Hara, A Kimura, T Miyazaki, H Tanaka, M Morimoto, K Nakai, J Soeda Cabozantinib inhibits AXL- and MET-dependent cancer cell migration induced by growth-arrest-specific 6 and hepatocyte growth factor Biochem Biophys Rep, 2020-01-17;21(0):100726. 2020-01-17 [PMID: 32055714] (Cell Culture, Human)	Cell Culture	Human
JP Hoj, B Mayro, AM Pendergast A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis Cell Rep, 2019-12-10;29(11):3421-3434.e8. 2019-12-10 [PMID: 31825826] (Cell Culture, Mouse)	Cell Culture	Mouse
D De Silva, Z Zhang, Y Liu, JS Parker, C Xu, L Cai, GG Wang, HS Earp, YE Whang Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen Sci Rep, 2019-12-09;9(1):18637. 2019-12-09 [PMID: 31819114] (Cell Culture, Human)	Cell Culture	Human
A Tutusaus, E de Gregori, B Cucarull, H Cristóbal, C Aresté, I Graupera, M Coll, A Colell, G Gausdal, JB Lorens, P García de, A Morales, M Marí A FUNCTIONAL ROLE OF GAS6/TAM IN NON-ALCOHOLIC STEATOHEPATITIS PROGRESSION IMPLICATES AXL AS THERAPEUTIC TARGET Cell Mol Gastroenterol Hepatol, 2019-11-02;0(0):. 2019-11-02 [PMID: 31689560] (Cell Culture, Human)	Cell Culture	Human
T Azad, K Nouri, HJ Janse van, SM Maritan, L Wu, Y Hao, T Montminy, J Yu, P Khanal, LM Mulligan, X Yang A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis Oncogene, 2019-09-02;0(0):. 2019-09-02 [PMID: 31477837] (Bioassay, Human)	Bioassay	Human
DP Strange, B Jiyarom, N Pourhabibi, X Xie, C Baker, H Sadri-Arde, PY Shi, S Verma Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells MBio, 2019-07-16;10(4):. 2019-07-16 [PMID: 31311882] (Bioassay, Human)	Bioassay	Human
Y Duan, B Hu, C Qiao, L Luo, X Li, J Wang, H Liu, T Zhou, B Shen, M Lv, J Feng Engineered AXL(-ECD)-Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration. Oncol Lett, 2019-04-15;17(6):5784-5792. 2019-04-15 [PMID: 31186805] (Bioassay, ELISA (Capture), Human)	Bioassay, ELISA (Capture)	Human
F Collina, L La Sala, F Liotti, N Prevete, E La Mantia, MG Chiofalo, G Aquino, L Arenare, M Cantile, G Liguori, F Di Gennaro, L Pezzullo, NS Losito, G Vecchio, G Botti, RM Melillo, R Franco AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer Cancers (Basel), 2019-06-07;11(6):. 2019-06-07 [PMID: 31181609] (Bioassay, Human)	Bioassay	Human
KA Mills, JM Quinn, ST Roach, M Palisoul, M Nguyen, H Noia, L Guo, J Fazal, DG Mutch, SA Wickline, H Pan, KC Fuh p5RHH nanoparticle-mediated delivery of AXL siRNA inhibits metastasis of ovarian and uterine cancer cells in mouse xenografts Sci Rep, 2019-03-18;9(1):4762. 2019-03-18 [PMID: 30886159] (Bioassay, Human)	Bioassay	Human
L Sinik, KA Minson, JJ Tentler, J Carrico, SM Bagby, WA Robinson, R Kami, T Burstyn-Co, SG Eckhardt, X Wang, SV Frye, HS Earp, D DeRyckere, DK Graham Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma Mol. Cancer Ther., 2018-11-27;18(2):278-288. 2018-11-27 [PMID: 30482852] (Bioassay, Human)	Bioassay	Human
LC Cheng, YL Chen, AN Cheng, AY Lee, CY Cho, JS Huang, SE Chuang AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells J. Biomed. Sci., 2018-11-12;25(1):80. 2018-11-12 [PMID: 30419905] (Activation, Human)	Activation	Human
K Fujita, X Chen, H Homma, K Tagawa, M Amano, A Saito, S Imoto, H Akatsu, Y Hashizume, K Kaibuchi, S Miyano, H Okazawa Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology Nat Commun, 2018-01-30;9(1):433. 2018-01-30 [PMID: 29382817] (Bioassay)	Bioassay
C Dantas-Bar, T Lesluyes, FL Loarer, F Chibon, I Treilleux, JM Coindre, P Meeus, M Brahmi, O Bally, I Ray-Coquar, MP Sunyach, AL Cesne, O Mir, S Bonvalot, M Toulmonde, A Italiano, P Saintigny, M Jean-Denis, F Ducimetier, D Ranchere, H El Sayadi, L Alberti, JY Blay Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma Br. J. Cancer, 2017-10-12;117(12):1787-1797. 2017-10-12 [PMID: 29024938] (Bioassay, Human)	Bioassay	Human
SN Cross, JA Potter, P Aldo, JY Kwon, M Pitruzzell, M Tong, S Guller, CV Rothlin, G Mor, VM Abrahams Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation J. Immunol., 2017-09-15;0(0):. 2017-09-15 [PMID: 28916522] (Bioassay, Human)	Bioassay	Human
ML Palisoul, JM Quinn, E Schepers, IS Hagemann, L Guo, K Reger, AR Hagemann, CK McCourt, PH Thaker, MA Powell, DG Mutch, KC Fuh Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer Mol. Cancer Ther., 2017-09-13;0(0):. 2017-09-13 [PMID: 28904132] (Bioassay, Human)	Bioassay	Human
L Xu, Y Chen, M Dutra-Clar, A Mayakonda, M Hazawa, SE Savinoff, N Doan, JW Said, WH Yong, A Watkins, H Yang, LW Ding, YY Jiang, JW Tyner, J Ching, JP Kovalik, V Madan, SL Chan, M Müschen, JJ Breunig, DC Lin, HP Koeffler BCL6 promotes glioma and serves as a therapeutic target Proc. Natl. Acad. Sci. U.S.A, 2017-03-29;0(0):. 2017-03-29 [PMID: 28356518] (Bioassay, Human)	Bioassay	Human
Kasikara C, Kumar S, Kimani S, Tsou W, Geng K, Davra V, Sriram G, Devoe C, Nguyen K, Antes A, Krantz A, Rymarczyk G, Wilczynski A, Empig C, Freimark B, Gray M, Schlunegger K, Hutchins J, Kotenko S, Birge R Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression. Mol Cancer Res, 2017-02-09;15(6):753-764. 2017-02-09 [PMID: 28184013] (ELISA (Standard))	ELISA (Standard)
Zhi-Min Yuan AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex J Mol Cell Biol, 2017-04-01;0(0):. 2017-04-01 [PMID: 27927748] (Bioassay, Human)	Bioassay	Human
Wilhem Leconet Therapeutic activity of anti-AXL antibody against triple-negative breast cancer Patient Derived Xenografts and metastasis Clin. Cancer Res, 2016-12-06;0(0):. 2016-12-06 [PMID: 27923843] (Western Blot)	Western Blot
KE Happonen, S Tran, M Mörgelin, R Prince, S Calzavarin, A Angelillo-, B Dahlbäck The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles J. Biol. Chem., 2016-03-22;291(20):10586-601. 2016-03-22 [PMID: 27006397] (Bioassay, Human)	Bioassay	Human
Show All 38 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	Binding assay/Protein-protein interaction		03/21/2018	View Summary Application Binding assay/Protein-protein interaction Lot DFGX0416121

Array 885-GSB

• Gas6 Antibodies
• Gas6 ELISA Kits
• Gas6 Lysate
• Gas6 Protein
• Gas6 ELISAs
• Gas6 Proteins and Enzymes