Recombinant Human Procalcitonin Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Procalcitonin (PCT) is encoded by a single CALCA gene, and can result in 2 alternatively spliced products: calcitonin and calcitonin-gene related peptide (CGRP) (1). Mature PCT is expressed as a 116 amino acid (aa) protein which is subsequently cleaved into 3 parts: a 57 aa pro-region, a 32 aa Calcitonin peptide and a 21 aa Katacalcin peptide (2, 3). PCT is moderately conserved among species, with human sharing 72% and 75% sequence identity with mouse and rat, respectively. In healthy adults, PCT is expressed by thyroid C cells and promptly converted to calcitonin (3). Calcitonin is directly involved in osteoclast activity and bone resorption (4). However, in states of inflammatory disease or bacterial infection, PCT is over-expressed from multiple cell types and the levels of unprocessed PCT rise significantly (3-5). These increased levels of PCT in circulation have been used as a diagnostic marker of systemic bacterial infection and sepsis and as a guide to antibiotic therapy (5, 6). More recently, the use of PCT as a disease marker has been expanded to include acute heart failure and vasculitic disorders (7, 8).

Array 9607-PN

• Procalcitonin Antibodies
• Procalcitonin ELISA Kits
• Procalcitonin Proteins
• Procalcitonin ELISA
• Procalcitonin Proteins and Enzyme