Recombinant Human PD-L2/B7-DC Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Programmed Death Ligand 2 (PD-L2), also known as B7-DC and butyrophilin-like protein, is a member of the B7 family of proteins that provide signals for regulating T-cell activation and tolerance (1). Mature human PD-L2 consists of a 201 amino acid (aa) extracellular domain (ECD) with one V-like and one C-like Ig domain, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain (2, 3). Within the ECD, mouse and human PD-L2 share 72% aa sequence identity. Alternative splicing generates additional isoforms that lack the second Ig-like domain and may be substituted and truncated following the first Ig-like domain (4). PD-L2 is expressed on dendritic cells, subsets of activated CD4⁺ and CD8⁺ T cells, and memory B cells that differentiate into plasma cells (3, 5, 6). At inflammatory sites such as rheumatoid arthritis, allergen exposure, and virus infection, PD-L2 is up-regulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells (7-11). PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand up-regulation while inhibiting IL-4 production (2, 3, 12, 13). In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance (14). In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production (9, 11).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 4 of 4.

Publications using 1224-PL	Applications	Species
M Ogishi, R Yang, C Aytekin, D Langlais, M Bourgey, T Khan, FA Ali, M Rahman, OM Delmonte, M Chrabieh, P Zhang, C Gruber, SJ Pelham, AN Spaan, J Rosain, WT Lei, S Drutman, MD Hellmann, MK Callahan, M Adamow, P Wong, JD Wolchok, G Rao, CS Ma, Y Nakajima, T Yaguchi, K Chamoto, SC Williams, JF Emile, F Rozenberg, MS Glickman, F Rapaport, G Kerner, G Allington, I Tezcan, D Cagdas, FO Hosnut, F Dogu, A Ikinciogul, VK Rao, L Kainulaine, V Béziat, J Bustamante, S Vilarinho, RP Lifton, B Boisson, L Abel, D Bogunovic, N Marr, LD Notarangel, SG Tangye, T Honjo, P Gros, S Boisson-Du, JL Casanova Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child Nature Medicine, 2021-06-28;0(0):. 2021-06-28 [PMID: 34183838] (Bioassay, Human)	Bioassay	Human
E Burova, A Hermann, J Waite, T Potocky, V Lai, S Hong, M Liu, O Allbritton, A Woodruff, Q Wu, A D'Orvillie, E Garnova, A Rafique, W Poueymirou, J Martin, T Huang, D Skokos, J Kantrowitz, J Popke, M Mohrs, D MacDonald, E Ioffe, W Olson, I Lowy, A Murphy, G Thurston Characterization of the anti-PD-1 antibody REGN2810 and its antitumor activity in human PD-1 knock-in mice Mol. Cancer Ther, 2017-03-06;0(0):. 2017-03-06 [PMID: 28265006] (Bioassay)	Bioassay
Azoulay-Alfaguter , Inbar, Strazza , Marianne, Pedoeem , Ariel, Mor , Adam The coreceptor programmed death 1 inhibits T-cell adhesion by regulating Rap1. J Allergy Clin Immunol, 2014-09-18;135(2):564-7. 2014-09-18 [PMID: 25240786] (Bioassay, Human)	Bioassay	Human
Steidl C, Shah SP, Woolcock BW MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature, 2011-03-02;471(7338):377-81. 2011-03-02 [PMID: 21368758] (Bioassay, Human)	Bioassay	Human

Array 1224-PL

• PD-L2/B7-DC/PDCD1LG2 Antibodies
• PD-L2/B7-DC/PDCD1LG2 Antibody Pair
• PD-L2/B7-DC/PDCD1LG2 Lysate
• PD-L2/B7-DC/PDCD1LG2 Proteins
• PD-L2/B7-DC/PDCD1LG2 ELISA
• PD-L2/B7-DC/PDCD1LG2 Proteins and Enzymes