Recombinant Human Oncostatin M (OSM) Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

OSM is a cytokine originally isolated from medium conditioned by PMA-treated U-937 human histiocytic leukemia cells based on its ability to inhibit growth of A375 melanoma cells. The human OSM cDNA encodes a 252 amino acid pre-pro-OSM polypeptide with a 25 residue hydrophobic signal peptide and a hydrophilic C-terminal domain that are proteolytically processed to generate the 196 residue mature form of OSM. Although both mature and pro-OSM are equally active in radio-receptor assays, the mature OSM is 5- to 60-fold more active in growth inhibition assays. Thus, proteolytic processing of the pro-OSM peptide may be important in regulating the in vivo activities of OSM.

OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. The gp130, a signal transducing component ( beta  subunit) of the IL-6, LIF and CNTF receptor complexes, was identified as a low-affinity OSM receptor that does not transduce OSM signals. The low affinity LIF receptor (LIF R, a gp130-related protein) has now been identified to be a component of a high-affinity OSM receptor that will transduce OSM signals. Since OSM is also active on cells that do not express LIF R, a specific OSM receptor that does not involve LIF R must also exist. Besides its growth inhibitory activities on human A375 melanoma and mouse M1 myeloid leukemic cells, as well as on other solid tumor cells, OSM also has growth stimulatory activities on normal fibroblasts, AIDS-Kaposi’s sarcoma cells, and a human erythroleukemia cell line, TF-1. Other OSM-mediated activities reported to date include: stimulation of plasminogen activator activity in cultured bovine aortic endothelial cells; regulation of IL-6 expression in human endothelial cells; and stimulation of LDL uptake and up-regulation of cell surface LDL receptors in HepG2 cells.

We have publications tested in 5 confirmed species: Human, Mouse, Equine, Porcine, Squirrel.

We have publications tested in 7 applications: Binding Assay, Bioassay, Cell Culture, Differentiation, ELISA (Standard), In Vivo, cells.

Showing Publications 1 - 10 of 79. Show All 79 Publications. Collapse Publications.

Publications using 295-OM	Applications	Species
Köhnke, T;Karigane, D;Hilgart, E;Fan, AC;Kayamori, K;Miyauchi, M;Collins, CT;Suchy, FP;Rangavajhula, A;Feng, Y;Nakauchi, Y;Martinez-Montes, E;Fowler, JL;Loh, KM;Nakauchi, H;Koldobskiy, MA;Feinberg, AP;Majeti, R; DNMT3AR882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell Frequency bioRxiv : the preprint server for biology 2024-10-29 [PMID: 39553934] (Bioassay, Human)	Bioassay	Human
Zhou, Y;Stevis, PE;Cao, J;Ehrlich, G;Jones, J;Rafique, A;Sleeman, MW;Olson, WC;Franklin, MC; Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes Nature communications 2024-11-12 [PMID: 39532904] (Bioassay, Human)	Bioassay	Human
Rafii, P;Cruz, PR;Ettich, J;Seibel, C;Padrini, G;Wittich, C;Lang, A;Petzsch, P;Köhrer, K;Moll, JM;Floss, DM;Scheller, J; Engineered Interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR The Journal of biological chemistry 2024-04-01 [PMID: 38569939] (Bioassay, Mouse)	Bioassay	Mouse
Suominen, S;Hyypijev, T;Venäläinen, M;Yrjänäinen, A;Vuorenpää, H;Lehti-Polojärvi, M;Räsänen, M;Seppänen, A;Hyttinen, J;Miettinen, S;Aalto-Setälä, K;Viiri, LE; Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures Cells 2023-09-27 [PMID: 37830581] (Bioassay, Human)	Bioassay	Human
Jovanovic, VM;Weber, C;Slamecka, J;Ryu, S;Chu, PH;Sen, C;Inman, J;De Sousa, JF;Barnaeva, E;Hirst, M;Galbraith, D;Ormanoglu, P;Jethmalani, Y;Mercado, JC;Michael, S;Ward, ME;Simeonov, A;Voss, TC;Tristan, CA;Singeç, I; A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells Stem cell reports 2023-07-04 [PMID: 37451260] (Bioassay, Human)	Bioassay	Human
Y Wang, Q Zheng, Z Sun, C Wang, J Cen, X Zhang, Y Jin, B Wu, T Yan, Z Wang, Q Gu, X Lv, J Nan, Z Wu, W Sun, G Pan, L Zhang, L Hui, X Cai Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytes Cell Stem Cell, 2023-04-13;0(0):. 2023-04-13 [PMID: 37059100] (Human)		Human
A Alexanova, E Raitoharju, J Valtonen, K Aalto-Setä, LE Viiri Coronary artery disease patient-derived iPSC-hepatocytes have distinct miRNA profile that may alter lipid metabolism Scientific Reports, 2023-01-30;13(1):1706. 2023-01-30 [PMID: 36717592] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
A Beucher, I Miguel-Esc, D Balboa, MG De Vas, MA Maestro, J Garcia-Hur, A Bernal, R Gonzalez-F, P Vargiu, H Heyn, P Ravassard, S Ortega, J Ferrer The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A Nature Cell Biology, 2022-10-06;0(0):. 2022-10-06 [PMID: 36202974] (Bioassay, Human)	Bioassay	Human
J Krumm, K Sekine, P Samaras, A Brazovskaj, M Breunig, R Yasui, A Kleger, H Taniguchi, M Wilhelm, B Treutlein, JG Camp, B Kuster High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development Cell Reports, 2022-03-29;38(13):110604. 2022-03-29 [PMID: 35354033] (Bioassay, Human)	Bioassay	Human
X Wang, Y Xiang, Y Yu, R Wang, Y Zhang, Q Xu, H Sun, ZA Zhao, X Jiang, X Wang, X Lu, D Qin, Y Quan, J Zhang, N Shyh-Chang, H Wang, N Jing, W Xie, L Li Formative pluripotent stem cells show features of epiblast cells poised for gastrulation Cell Research, 2021-02-19;0(0):. 2021-02-19 [PMID: 33608671] (Bioassay, Mouse)	Bioassay	Mouse
PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey, MA Caporizzo, R Linares-Sa, JG Heffler, N Sayed, D Thomas, Q Wang, LJ Stanton, K Bedi, MP Morley, TP Cappola, AT Owens, KB Margulies, DB Frank, JC Wu, DJ Rader, W Yang, BL Prosser, K Musunuru, R Jain Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes Cell Stem Cell, 2021-02-01;0(0):. 2021-02-01 [PMID: 33529599] (Bioassay, Human)	Bioassay	Human
F Michielin, GG Giobbe, C Luni, Q Hu, I Maroni, MR Orford, A Manfredi, L Di Filippo, AL David, D Cacchiarel, P De Coppi, S Eaton, N Elvassore The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs Cell Rep, 2020-12-01;33(9):108453. 2020-12-01 [PMID: 33264615] (Bioassay, Human)	Bioassay	Human
X Gao, R Li, P Cahan, Y Zhao, JJ Yourick, RL Sprando Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study Stem Cell Res Ther, 2020-09-11;11(1):393. 2020-09-11 [PMID: 32917265] (Cell Culture, Human)	Cell Culture	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
PA Subramani, N Vartak-Sha, S Sreekumar, P Mathur, B Nayer, S Dakhore, SK Basavanna, DM Kalappa, RV Krishnamur, B Mukhi, P Mishra, N Yoshida, SK Ghosh, R Shandil, S Narayanan, B Campo, K Hasegawa, AR Anvikar, N Valecha, V Sundaramur Plasmodium vivax liver stage assay platforms using Indian clinical isolates Malar. J., 2020-06-22;19(1):214. 2020-06-22 [PMID: 32571333] (Bioassay, Human)	Bioassay	Human
NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells Nat. Biotechnol., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094658] (cells, Human)	cells	Human
MA Phillips, A Cánovas, MA Rea, A Islas-Trej, JF Medrano, B Durbin-Joh, DM Rocke, RH Rice Deducing signaling pathways from parallel actions of arsenite and antimonite in human epidermal keratinocytes Sci Rep, 2020-02-19;10(1):2890. 2020-02-19 [PMID: 32076005] (Bioassay, Human)	Bioassay	Human
Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells Nat. Immunol., 2020-02-17;21(3):274-286. 2020-02-17 [PMID: 32066947] (Cell Culture, Human)	Cell Culture	Human
K Fujimoto, A Shioi, Y Miki, Y Kakutani, T Morioka, T Shoji, M Emoto, M Inaba Adenosine Attenuates Aortic Smooth Muscle Cell Calcification through A3 Adenosine Receptor Tohoku J. Exp. Med., 2019-12-01;249(4):275-283. 2019-12-01 [PMID: 31875581] (Bioassay, Human)	Bioassay	Human
D Parashar, A Geethadevi, MR Aure, J Mishra, J George, C Chen, MK Mishra, A Tahiri, W Zhao, B Nair, Y Lu, LS Mangala, C Rodriguez-, G Lopez-Bere, AKS Camara, M Liang, JS Rader, R Ramchandra, M You, AK Sood, VN Kristensen, GB Mills, S Pradeep, P Chaluvally miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer Cell Rep, 2019-12-24;29(13):4389-4406.e10. 2019-12-24 [PMID: 31875548] (Cell Culture, Human)	Cell Culture	Human
F Tonon, GG Giobbe, A Zambon, C Luni, O Gagliano, A Floreani, G Grassi, N Elvassore In vitro metabolic zonation through oxygen gradient on a chip Sci Rep, 2019-09-19;9(1):13557. 2019-09-19 [PMID: 31537830] (Bioassay, Human)	Bioassay	Human
RE Jones, A Salhotra, KS Robertson, RC Ransom, DS Foster, HN Shah, N Quarto, DC Wan, MT Longaker Skeletal Stem Cell-Schwann Cell Circuitry in Mandibular Repair Cell Rep, 2019-09-10;28(11):2757-2766.e5. 2019-09-10 [PMID: 31509739] (In Vivo, Mouse)	In Vivo	Mouse
JM Segal, D Kent, DJ Wesche, SS Ng, M Serra, B Oulès, G Kar, G Emerton, SJI Blackford, S Darmanis, R Miquel, TV Luong, R Yamamoto, A Bonham, W Jassem, N Heaton, A Vigilante, A King, R Sancho, S Teichmann, SR Quake, H Nakauchi, ST Rashid Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors Nat Commun, 2019-07-26;10(1):3350. 2019-07-26 [PMID: 31350390] (Bioassay, Human)	Bioassay	Human
H Okada, C Nakanishi, S Yoshida, M Shimojima, J Yokawa, M Mori, H Tada, T Yoshimuta, K Hayashi, T Yamano, R Hanayama, M Yamagishi, MA Kawashiri Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia Sci Rep, 2019-03-18;9(1):4695. 2019-03-18 [PMID: 30886174] (Bioassay, Human)	Bioassay	Human
L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos Nat Commun, 2019-01-21;10(1):364. 2019-01-21 [PMID: 30664750] (Bioassay, Human)	Bioassay	Human
J Kim, Y Kim, J Choi, H Jung, K Lee, J Kang, N Park, YA Rim, Y Nam, JH Ju Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis Stem Cell Res Ther, 2018-12-29;9(1):357. 2018-12-29 [PMID: 30594247] (Bioassay, Human)	Bioassay	Human
S Müller, A Versini, F Sindikubwa, G Belthier, S Niyomchon, J Pannequin, L Grimaud, T Cañeque, R Rodriguez Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells PLoS ONE, 2018-11-06;13(11):e0206764. 2018-11-06 [PMID: 30399175] (Bioassay, Human)	Bioassay	Human
D van Keulen, MG Pouwer, G Pasterkamp, AJ van Gool, MD Sollewijn, HMG Princen, D Tempel Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice PLoS ONE, 2018-10-01;13(10):e0204911. 2018-10-01 [PMID: 30273401] (Bioassay, Human)	Bioassay	Human
A Skrzypczyk, S Kehr, I Krystel, SH Bernhart, S Giri, A Bader, PF Stadler Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes Stem Cells Int, 2018-08-19;2018(0):5692840. 2018-08-19 [PMID: 30210551] (Bioassay, Human)	Bioassay	Human
H Ayabe, T Anada, T Kamoya, T Sato, M Kimura, E Yoshizawa, S Kikuchi, Y Ueno, K Sekine, JG Camp, B Treutlein, A Ferguson, O Suzuki, T Takebe, H Taniguchi Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling Stem Cell Reports, 2018-07-19;0(0):. 2018-07-19 [PMID: 30033085] (Bioassay, Human)	Bioassay	Human
M Yanez Arte, T Kjellman, S Bartesaghi, S Wallin, X Wu, AJ Kvist, A Dabkowska, N Székely, A Radulescu, J Bergenholt, L Lindfors Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles Proc. Natl. Acad. Sci. U.S.A., 2018-03-27;0(0):. 2018-03-27 [PMID: 29588418] (Bioassay, Human)	Bioassay	Human
J Ou, JM Ball, Y Luan, T Zhao, KJ Miyagishim, Y Xu, H Zhou, J Chen, DK Merriman, Z Xie, BS Mallon, W Li iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications Cell, 2018-03-22;0(0):. 2018-03-22 [PMID: 29576452] (Bioassay, Squirrel)	Bioassay	Squirrel
WS Fagg, N Liu, MJ Yang, K Cheng, E Chung, JS Kim, G Wu, J Fair Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver Cell Transplant, 2017-12-01;26(12):1868-1877. 2017-12-01 [PMID: 29390880] (Bioassay, Mouse)	Bioassay	Mouse
YJ Han, YH Kang, SB Shivakumar, D Bharti, YB Son, YH Choi, WU Park, JH Byun, GJ Rho, BW Park Stem Cells from Cryopreserved Human Dental Pulp Tissues Sequentially Differentiate into Definitive Endoderm and Hepatocyte-Like Cells in vitro Int J Med Sci, 2017-11-02;14(13):1418-1429. 2017-11-02 [PMID: 29200956] (Bioassay, Human)	Bioassay	Human
T Oike, Y Sato, T Kobayashi, K Miyamoto, S Nakamura, Y Kaneko, S Kobayashi, K Harato, H Saya, M Matsumoto, M Nakamura, Y Niki, T Miyamoto Stat3 as a potential therapeutic target for rheumatoid arthritis Sci Rep, 2017-09-08;7(1):10965. 2017-09-08 [PMID: 28887478] (Bioassay, Human)	Bioassay	Human
JG Camp, K Sekine, T Gerber, H Loeffler-W, H Binder, M Gac, S Kanton, J Kageyama, G Damm, D Seehofer, L Belicova, M Bickle, R Barsacchi, R Okuda, E Yoshizawa, M Kimura, H Ayabe, H Taniguchi, T Takebe, B Treutlein Multilineage communication regulates human liver bud development from pluripotency Nature, 2017-06-14;0(0):. 2017-06-14 [PMID: 28614297] (Bioassay, Human)	Bioassay	Human
Q Li, AP Hutchins, Y Chen, S Li, Y Shan, B Liao, D Zheng, X Shi, Y Li, WY Chan, G Pan, S Wei, X Shu, D Pei A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes Nat Commun, 2017-05-03;8(0):15166. 2017-05-03 [PMID: 28466868] (Bioassay, Human)	Bioassay	Human
EE Pashos, Y Park, X Wang, A Raghavan, W Yang, D Abbey, DT Peters, J Arbelaez, M Hernandez, N Kuperwasse, W Li, Z Lian, Y Liu, W Lv, SL Lytle-Gabb, DH Marchadier, P Rogov, J Shi, KJ Slovik, IM Stylianou, L Wang, R Yan, X Zhang, S Kathiresan, SA Duncan, TS Mikkelsen, EE Morrisey, DJ Rader, CD Brown, K Musunuru Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci Cell Stem Cell, 2017-04-06;20(4):558-570.e10. 2017-04-06 [PMID: 28388432] (Bioassay, Human)	Bioassay	Human
G Chandrika, K Natesh, D Ranade, A Chugh, P Shastry Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells Tumour Biol., 2017-03-01;39(3):1010428317695. 2017-03-01 [PMID: 28351321] (Bioassay, Human)	Bioassay	Human
BC Narmada, YT Goh, H Li, S Sinha, H Yu, C Cheung Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals Stem Cells Transl Med, 2016-10-07;6(3):851-863. 2016-10-07 [PMID: 28297582] (Bioassay, Human)	Bioassay	Human
Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, L Huan, HS Tan, R Kanesvaran, H Yu, MH Tan Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity Sci Rep, 2017-01-25;7(0):41238. 2017-01-25 [PMID: 28120901] (Bioassay, Human)	Bioassay	Human
Yan-Jin Zhang Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via Nsp5 by Inducing STAT3 Degradation J. Virol., 2017-01-18;0(0):. 2017-01-18 [PMID: 27881658] (Bioassay, Porcine)	Bioassay	Porcine
Danièle Noel Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFN?-Primed Equine Mesenchymal Stem Cells Front Immunol, 2016-09-27;7(0):392. 2016-09-27 [PMID: 27729913] (Bioassay, Equine)	Bioassay	Equine
Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow Nat Cell Biol, 2016-09-19;18(10):1078-1089. 2016-09-19 [PMID: 27642788] (Bioassay, Human)	Bioassay	Human
Murine Oncostatin M acts via Leukemia Inhibitory Factor Receptor to phosphorylate STAT3 but not STAT1, an effect that protects bone mass J Biol Chem, 2016-08-18;0(0):. 2016-08-18 [PMID: 27539849] (Bioassay, Mouse)	Bioassay	Mouse
Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus Sci Rep, 2016-07-08;6(0):29358. 2016-07-08 [PMID: 27386799] (Bioassay, Human)	Bioassay	Human
Yang W, Liu Y, Slovik K, Wu J, Duncan S, Rader D, Morrisey E Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells. PLoS ONE, 2015-08-17;10(8):e0134995. 2015-08-17 [PMID: 26281015] (Bioassay, Human)	Bioassay	Human
Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir Res, 2015-02-07;16(0):14. 2015-02-07 [PMID: 25849622] (Bioassay, Human)	Bioassay	Human
Nagiec M, Skepner A, Negri J, Eichhorn M, Kuperwasser N, Comer E, Muncipinto G, Subramanian A, Clish C, Musunuru K, Duvall J, Foley M, Perez J, Palmer M Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS ONE, 2015-03-26;10(3):e0120295. 2015-03-26 [PMID: 25811180] (Bioassay, Human)	Bioassay	Human
Bhardwaj R, Yester J, Singh S, Biswas D, Surace M, Waters M, Hauser K, Yao Z, Boyce B, Kordula T RelB/p50 complexes regulate cytokine-induced YKL-40 expression. J Immunol, 2015-02-13;194(6):2862-70. 2015-02-13 [PMID: 25681350] (Bioassay, Human)	Bioassay	Human
Czysz , Katherin, Minger , Stephen, Thomas , Nick DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation. PLoS ONE, 2015-02-06;10(2):e0117689. 2015-02-06 [PMID: 25659159] (Bioassay, Human)	Bioassay	Human
Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J The expression and regulation of chemerin in the epidermis. PLoS ONE, 2015-02-06;10(2):e0117830. 2015-02-06 [PMID: 25659101] (Bioassay, Human)	Bioassay	Human
Ehlting C, Bohmer O, Hahnel M, Thomas M, Zanger U, Gaestel M, Knoefel W, Schulte Am Esch J, Haussinger D, Bode J Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2. Cell Signal, 2015-01-03;27(3):555-67. 2015-01-03 [PMID: 25562430] (Bioassay, Human)	Bioassay	Human
Gao W, Zhou P, Ma X, Tschudy-Seney B, Chen J, Magner N, Revzin A, Nolta J, Zern M, Duan Y Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro. PLoS ONE, 2014-11-13;9(11):e112698. 2014-11-13 [PMID: 25393427] (Bioassay, Human)	Bioassay	Human
Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, Maynard D, Lehuede C, Muller C, Valet P, Gespach C, Bracke M, Cocquyt V, Denys H, De Wever O Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res, 2014-09-24;74(23):6806-19. 2014-09-24 [PMID: 25252914] (Bioassay, Human)	Bioassay	Human
Pini L, Tiberio L, Venkatesan N, Bezzi M, Corda L, Luisetti M, Ferrarotti I, Malerba M, Lomas D, Janciauskiene S, Vizzardi E, Modina D, Schiaffonati L, Tantucci C The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency. Respir Res, 2014-09-14;15(0):112. 2014-09-14 [PMID: 25218041] (Bioassay, Human)	Bioassay	Human
Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M. PLoS ONE, 2014-07-10;9(7):e101937. 2014-07-10 [PMID: 25010647] (Bioassay, Human)	Bioassay	Human
Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, Walsh N Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts. Cytokine, 2014-04-22;68(2):101-9. 2014-04-22 [PMID: 24767864] (Bioassay, Human)	Bioassay	Human
Takebe , Takanori, Zhang , Ran-Ran, Koike , Hiroyuki, Kimura , Masaki, Yoshizawa , Emi, Enomura , Masahiro, Koike , Naoto, Sekine , Keisuke, Taniguchi , Hideki Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc, 2014-01-23;9(2):396-409. 2014-01-23 [PMID: 24457331] (Bioassay, Human)	Bioassay	Human
Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports, 2013-10-03;1(4):322-35. 2013-10-03 [PMID: 24319667] (Bioassay, Human)	Bioassay	Human
Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue M, Mizuguchi H CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision. Development, 2013-11-27;141(1):91-100. 2013-11-27 [PMID: 24284203] (Bioassay, Human)	Bioassay	Human
van 't Wout E, Dickens J, van Schadewijk A, Haq I, Kwok H, Ordonez A, Murphy G, Stolk J, Lomas D, Hiemstra P, Marciniak S Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z alpha1-antitrypsin. Hum Mol Genet, 2013-10-04;23(4):929-41. 2013-10-04 [PMID: 24097797] (Bioassay, Human)	Bioassay	Human
Hannan , Nicholas, Segeritz , Charis-P, Touboul , Thomas, Vallier , Ludovic Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc, 2013-01-01;8(2):430-7. 2013-01-01 [PMID: 23370178] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Roelandt P, Pauwelyn KA, Sancho-Bru P Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010-08-11;5(8):e12101. 2010-08-11 [PMID: 20711405] (Cell Culture, Human)	Cell Culture	Human
Larsen JV, Hansen M, Moller B, Madsen P, Scheller J, Nielsen M, Petersen CM Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. Mol. Cell. Biol., 2010-06-28;17(0):4175. 2010-06-28 [PMID: 20584990] (Bioassay, Human)	Bioassay	Human
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis. J. Immunol., 2010-03-24;184(0):5263-70. 2010-03-24 [PMID: 20335534] (Bioassay, Human)	Bioassay	Human
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int. J. Cancer, 2009-07-15;125(2):367-73. 2009-07-15 [PMID: 19378341] (Bioassay, Human)	Bioassay	Human
Rahmoun M, Moles JP, Pedretti N, Mathieu M, Fremaux I, Raison-Peyron N, Lecron JC, Yssel H, Pene J Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. J. Invest. Dermatol., 2008-10-09;129(3):671-81. 2008-10-09 [PMID: 18843289] (Bioassay, Human)	Bioassay	Human
Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392. 2008-04-14 [PMID: 18410958] (Bioassay, Human)	Bioassay	Human
Brechter AB, Lerner UH Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum., 2007-03-01;56(3):910-23. 2007-03-01 [PMID: 17328065] (Bioassay, Human)	Bioassay	Human
Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J. Immunol., 2006-12-01;177(11):7665-72. 2006-12-01 [PMID: 17114436] (Bioassay, Human)	Bioassay	Human
Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Arthritis Rheum., 2006-10-01;54(10):3152-62. 2006-10-01 [PMID: 17009243] (Bioassay, Human)	Bioassay	Human
Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int. J. Dev. Biol., 2006-01-01;50(7):645-52. 2006-01-01 [PMID: 16892178] (Bioassay, Human)	Bioassay	Human
He W, Gong K, Smith DK, Ip NY The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling. FEBS Lett., 2005-08-15;579(20):4317-23. 2005-08-15 [PMID: 16051226] (Binding Assay, Bioassay, Human)	Binding Assay, Bioassay	Human
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol., 2002-11-01;169(9):5244-51. 2002-11-01 [PMID: 12391243] (Bioassay, ELISA (Standard), Human)	Bioassay, ELISA (Standard)	Human
Scaffidi AK, 2019, Mutsaers SE, Moodley YP, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts. 3821-3828, 2002-07-01;136(5):793-801. 2002-07-01 [PMID: 12086989] (Bioassay, Human)	Bioassay	Human
Savarese TM, Campbell CL, McQuain C, Mitchell K, Guardiani R, Quesenberry PJ, Nelson BE Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas. Cytokine, 2002-03-21;17(6):324-34. 2002-03-21 [PMID: 12061840] (Bioassay, Human)	Bioassay	Human
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Array 295-OM

• Oncostatin M/OSM Antibodies
• Oncostatin M/OSM ELISA Kit
• Oncostatin M/OSM Lysate
• Oncostatin M/OSM Proteins
• Oncostatin M/OSM Proteins and Enzymes
• Oncostatin M/OSM ELISAs