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OSMR beta Antibody

 (15 Publications)
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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Biotin
BAF662
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
AF662-SP
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OSMR beta Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse OSM R beta
Glu24-Leu738
Accession # O70458
Specificity
Detects mouse OSM R beta in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
Osmr
Purity Statement
Antigen Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF662 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for OSMR beta Antibody

  • IL-31 receptor subunit beta
  • IL-31R subunit beta
  • IL-31RB
  • IL-31R-beta
  • Interleukin-31 receptor subunit beta
  • MGC150627
  • MGC75127
  • oncostatin M receptor
  • oncostatin-M specific receptor beta subunit
  • oncostatin-M-specific receptor subunit beta
  • OSM R beta
  • OSMR beta
  • OSMR
  • OSMRB
  • OSMRBMGC150626
  • PLCA1

Background

Oncostatin M (OSM) is a member of the IL-6 family of cytokines that share the gp130 as a common signal transducing receptor subunit. Human OSM signals through two types of human OSM receptor complexes: the type I complex comprising the leukemia inhibitory factor receptor beta (LIF R beta ) and gp130, the type II complex made up of OSM receptor beta (OSM R beta ) and gp130. In contrast, mouse OSM signals only through the mouse OSM R beta and gp130 complex. Mouse OSM R beta cDNA encodes a 971 amino acid (aa) residue type I transmembrane protein which contains a 23 aa residue signal peptide, an extracellular domain of 714 aa, a transmembrane domain of 20 aa and a 214 aa cytoplasmic domain. Mouse OSM R beta alone binds mOSM with low-affinity, but forms a high-affinity binding complex in the presence of gp130. Mouse OSM R beta is 55% identical at the amino acid sequence level to human OSM R beta .

  1. Lindberg, R.A. et al. (1998) Mol. Cell. Biol. 18:3357.
  2. Tanaka, M. et al. (1999) Blood 93:804.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for OSMR beta Antibody (AF662)(15)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.

We have publications tested in 5 applications: ELISA Development, Flow Cytometry, IHC, IHC-P, Western Blot.


Filter By Application
ELISA Development
(1)
Flow Cytometry
(2)
IHC
(3)
IHC-P
(1)
Western Blot
(8)
All Applications
Filter By Species
Human
(1)
Mouse
(12)
Rat
(1)
Transgenic Mouse
(2)
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Showing Publications 1 - 10 of 15. Show All 15 Publications.
Publications using AF662 Applications Species
Bilgic, SN;Domaniku, A;Toledo, B;Agca, S;Weber, BZC;Arabaci, DH;Ozornek, Z;Lause, P;Thissen, JP;Loumaye, A;Kir, S; EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia Nature 2023-05-01 [PMID: 37165186] (IHC, Transgenic Mouse, Mouse) IHC Transgenic Mouse, Mouse
T Komori, Y Morikawa Essential roles of the cytokine oncostatin M in crosstalk between muscle fibers and immune cells in skeletal muscle after aerobic exercise The Journal of Biological Chemistry, 2022-11-09;0(0):102686. 2022-11-09 [PMID: 36370846] (IHC, Western Blot, Mouse) IHC, Western Blot Mouse
H Lörchner, JM Adrian-Seg, C Waechter, R Wagner, ME Góes, N Brachmann, K Sreenivasa, A Wietelmann, S Günther, N Doll, T Braun, J Pöling Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice International Journal of Molecular Sciences, 2021-12-29;23(1):. 2021-12-29 [PMID: 35008777] (Western Blot, Mouse) Western Blot Mouse
M Valussi, J Besser, K Wystub-Lis, S Zukunft, M Richter, T Kubin, T Boettger, T Braun Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart Science Advances, 2021-10-13;7(42):eabi6648. 2021-10-13 [PMID: 34644107] (Western Blot, Mouse, Rat, Transgenic Mouse) Western Blot Mouse, Rat, Transgenic Mouse
J Martínez-F, A Prescott, S van Kaster, DL Pedrioli, I McLean, A Moles, T Reinheckel, V Poli, C Watts Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis Nat Commun, 2018-12-17;9(1):5343. 2018-12-17 [PMID: 30559339] (Western Blot, Mouse) Western Blot Mouse
Jacqueline M. Stephens, Jennifer L. Bailey, Hardy Hang, Victoria Rittell, Marilyn A. Dietrich, Randall L. Mynatt et al. Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte‐Specific Oncostatin Receptor Knockout Mice Obesity (Silver Spring) 9/1/2018 [PMID: 30226002]
Carrie M Elks Loss of oncostatin M signaling in adipocytes induces insulin resistance and adipose tissue inflammation in vivo J Biol Chem, 2016-06-20;0(0):. 2016-06-20 [PMID: 27325693] (Western Blot, Mouse) Western Blot Mouse
Shamsudheen Moidunny, Marco Matos, Evelyn Wesseling, Santanu Banerjee, David J. Volsky, Rodrigo A. Cunha et al. Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity Journal of Neuroinflammation 12/1/2016 [PMID: 27287400]
Ehlting C, Bohmer O, Hahnel M, Thomas M, Zanger U, Gaestel M, Knoefel W, Schulte Am Esch J, Haussinger D, Bode J Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2. Cell Signal, 2015-01-03;27(3):555-67. 2015-01-03 [PMID: 25562430] (Western Blot, Mouse) Western Blot Mouse
Guihard P, Boutet M, Brounais-Le Royer B, Gamblin A, Amiaud J, Renaud A, Berreur M, Redini F, Heymann D, Layrolle P, Blanchard F Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol, 2015-01-02;185(3):765-75. 2015-01-02 [PMID: 25559270] (IHC, Mouse) IHC Mouse
Show All 15 Publications.

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Bioinformatics

Gene Symbol Osmr
Uniprot