Recombinant Human Neurofascin Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neurofascin, a type I transmembrane glycoprotein, is a member of the L1 family of cell adhesion molecules (CAMs) (1-4). L1CAM family members are composed of an extracellular domain (ECD) that contains six immunoglobulin (Ig)-like domains and multiple fibronectin type III repeats, followed by transmembrane and cytoplasmic domains (2, 4, 5). Multiple isoforms of Neurofascin, including NF155, NF166, NF180, and NF186, can be generated by alternative splicing with a predicted range of approximately 70 kDa to 150 kDa (4). These isoforms differ in the combination of fibronectin type III repeats, as well as in the presence of a proline-, alanine-, and threonine-rich segment (PAT domain) located just after the fourth fibronectin type III repeat (4). This recombinant human Neurofascin protein is most close to NF155 and shares 96% amino acid sequence identity with comparable regions of rat and mouse homologs. In rats, NF155 is transiently expressed by oligodendrocytes and Schwann cells during axon myelination (6, 7). NF155 clusters in paranodal regions of oligodendroglia and binds to the Caspr-Contactin complex located on the adjacent axon to form and stabilize paranodal axoglial junctions (8-11). It has been suggested that the ECD of NF155 must be cleaved from oligodendroglia membranes to form and/or stabilize the paranodal structure (12). NF155 has also been shown to promote neuronal adhesion and neurite outgrowth in rats and chickens (12-14). Alterations in NF155 expression have been associated with multiple sclerosis (15).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, ELISA(Detection).

Showing Publications 1 - 2 of 2.

Publications using 8208-NF	Applications	Species
AJ Davies, J Fehmi, M Senel, H Tumani, J Dorst, S Rinaldi Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies J Clin Med, 2020-06-27;9(7):. 2020-06-27 [PMID: 32605107] (ELISA(Detection), Human)	ELISA(Detection)	Human
Katsunori Ikewaki IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay J. Neuroimmunol., 2016-11-09;0(0):. 2016-11-09 [PMID: 27852440] (Bioassay, Human)	Bioassay	Human

Array 8208-NF

• Neurofascin Antibodies
• Neurofascin ELISA Kits
• Neurofascin Protein
• Neurofascin Proteins and Enzymes