Recombinant Human INSRR Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Insulin Receptor-related Receptor (INSRR) is a type I transmembrane glycoprotein in the Insulin/IGF receptor family of receptor tyrosine kinases (1). The mature receptor contains an extracellular alpha subunit and an extracellular/transmembrane/cytoplasmic beta subunit. The amino acid 1-923 encodes the extracellular domain. Alternative splicing generates A and B isoforms which may homodimerize or heterodimerize with the IGF-I receptor (2). INSRR signaling regulates glucose uptake and metabolism but also contributes to cell growth, differentiation and apoptosis. INSRR is specifically and reversibly activated by alkaline media through a positive cooperativity mechanism. It also triggers receptor conformational changes and elicits intracellular signaling. INSRR is predominantly expressed in organs that come in contact with mildly alkaline media, and is postulated to be an alkali sensor to manage metabolic bicarbonate excess in kidney (3). Mutations in INSRR have been linked to severe insulin resistance (type A and Rabson-Mendenhall syndrome), type II diabetes mellitus, and leprechaunism (Donohue syndrome) (4, 5). Human INSRR shares 89% identity with mouse and rat INSRR.

Array 9566-RR

• INSRR/IR-related receptor Antibodies
• INSRR/IR-related receptor Lysate
• INSRR/IR-related receptor Protein
• INSRR/IR-related receptor Proteins and Enzyme