Recombinant Human IL-10 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 10, also known as cytokine synthesis inhibitory factor (CSIF), is the charter member of the IL‑10 family of alpha ‑helical cytokines that also includes
IL‑19, IL‑20, IL‑22, IL‑24, and IL‑26/AK155 (1, 2). IL‑10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts (2‑5). Mature human IL‑10 shares 72%‑86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL‑10. Whereas human IL‑10 is active on mouse cells, mouse IL‑10 does not act on human cells (6, 7). IL‑10 is a 178 amino acid molecule that contains two intrachain disulfide bridges and is expressed as a 36 kDa noncovalently associated homodimer (6, 8, 9). The IL‑10 dimer binds to two IL‑10 R alpha /IL‑10 R1 chains, resulting in recruitment of two IL‑10 R beta /IL‑10 R2 chains and activation of a signaling cascade involving JAK1, TYK2, and STAT3 (10). IL‑10 R beta does not bind IL‑10 by itself but is required for signal transduction (1). IL‑10 R beta also associates with IL‑20 R alpha , IL‑22R alpha , or IL‑28 R alpha to form the receptor complexes for IL‑22, IL‑26, IL‑28, and IL‑29
(11‑13). IL‑10 is a critical molecule in the control of viral infections and allergic and autoimmune inflammation (14‑16). It promotes phagocytic uptake and Th2 responses but suppresses antigen presentation and Th1 proinflammatory responses (2).

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Hamster, N/A, Primate - Papio anubis (Olive Baboon).

We have publications tested in 9 applications: Bioassay, Cell Culture, Control, Differentiation, ELISA (Standard), In Vivo, Organoid Culture, SDS-Page, Spheroid Culture.

Showing Publications 1 - 10 of 110. Show All 110 Publications. Collapse Publications.

Publications using 217-IL	Applications	Species
Cheng, YC;Acedera, JD;Li, YJ;Shieh, SY; A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis Cell death and differentiation 2024-05-07 [PMID: 38714880] (Bioassay, Human)	Bioassay	Human
Papareddy, P;Tapken, I;Kroh, K;Varma Bhongir, RK;Rahman, M;Baumgarten, M;Cim, EI;Györffy, L;Smeds, E;Neumann, A;Veerla, S;Olinder, J;Thorlacus, H;Ryden, C;Bartakova, E;Holub, M;Herwald, H; The role of extracellular vesicle fusion with target cells in triggering systemic inflammation Nature communications 2024-02-07 [PMID: 38326335] (Bioassay, Human)	Bioassay	Human
Múnera, JO;Kechele, DO;Bouffi, C;Qu, N;Jing, R;Maity, P;Enriquez, JR;Han, L;Campbell, I;Mahe, MM;McCauley, HA;Zhang, X;Sundaram, N;Hudson, JR;Zarsozo-Lacoste, A;Pradhan, S;Tominaga, K;Sanchez, JG;Weiss, AA;Chatuvedi, P;Spence, JR;Hachimi, M;North, T;Daley, GQ;Mayhew, CN;Hu, YC;Takebe, T;Helmrath, MA;Wells, JM; Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon Cell stem cell 2023-11-02 [PMID: 37922878] (Organoid Culture, Human)	Organoid Culture	Human
Katagata, M;Okayama, H;Nakajima, S;Saito, K;Sato, T;Sakuma, M;Fukai, S;Endo, E;Sakamoto, W;Saito, M;Saze, Z;Momma, T;Mimura, K;Kono, K; TIM-3 Expression and M2 Polarization of Macrophages in the TGF?-Activated Tumor Microenvironment in Colorectal Cancer Cancers 2023-10-11 [PMID: 37894310] (Cell Culture)	Cell Culture
H Asashima, S Mohanty, M Comi, WE Ruff, KB Hoehn, P Wong, J Klein, C Lucas, I Cohen, S Coffey, N Lele, L Greta, K Raddassi, O Chaudhary, A Unterman, B Emu, SH Kleinstein, RR Montgomery, A Iwasaki, CS Dela Cruz, N Kaminski, AC Shaw, DA Hafler, TS Sumida PD-1highCXCR5-CD4+ peripheral helper T�cells promote CXCR3+ plasmablasts in human acute viral infection Cell Reports, 2023-01-02;0(0):111895. 2023-01-02 [PMID: 36596303] (Cell Culture, Human)	Cell Culture	Human
H Gunawardan, T Romero, N Yao, S Heidt, A Mulder, DA Elashoff, NM Valenzuela Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses Scientific Reports, 2021-01-21;11(1):1949. 2021-01-21 [PMID: 33479269] (Bioassay, Human)	Bioassay	Human
P Shrestha, DA Davis, HK Jaeger, A Stream, AI Aisabor, R Yarchoan Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2 PloS Pathogens, 2021-01-07;17(1):e1009091. 2021-01-07 [PMID: 33411730] (Bioassay, Human)	Bioassay	Human
J Chen, X Xu, Y Li, F Li, J Zhang, Q Xu, W Chen, Y Wei, X Wang Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity Cell Death and Differentiation, 2020-12-10;0(0):. 2020-12-10 [PMID: 33303977] (Cell Culture, Mouse)	Cell Culture	Mouse
J Stebbing, G Sánchez Ni, M Falcone, S Youhanna, P Richardson, S Ottaviani, JX Shen, C Sommerauer, G Tiseo, L Ghiadoni, A Virdis, F Monzani, LR Rizos, F Forfori, A Avendaño-C, S De Marco, L Carrozzi, F Lena, PM Sánchez-Ju, LG Lacerenza, N Cesira, D Caldevilla, A Perrella, L Niccoli, LS Méndez, D Matarrese, D Goletti, YJ Tan, V Monteil, G Dranitsari, F Cantini, A Farcomeni, S Dutta, SK Burley, H Zhang, M Pistello, W Li, M Mas Romero, F Andrés Pre, RS Simón-Tale, R García-Mol, C Kutter, JH Felce, ZF Nizami, AG Miklosi, JM Penninger, F Menichetti, A Mirazimi, P Abizanda, VM Lauschke JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality Sci Adv, 2021-01-01;0(0):. 2021-01-01 [PMID: 33187978] (Spheroid Culture, Human)	Spheroid Culture	Human
MY Hsieh, JJ Lin, SH Hsia, JL Huang, KW Yeh, KW Chang, WI Lee Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES) Biomed J, 2020-05-29;0(0):. 2020-05-29 [PMID: 32651134] (Bioassay, Human)	Bioassay	Human
MF Abas?yan?k, K Wolfe, H Van Phan, J Lin, B Laxman, SR White, PA Verhoef, GM Mutlu, B Patel, S Tay Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes Nat Commun, 2020-05-25;11(1):2607. 2020-05-25 [PMID: 32451375] (Bioassay, Human)	Bioassay	Human
L Sun, M Girnary, L Wang, Y Jiao, E Zeng, K Mercer, J Zhang, JT Marchesan, N Yu, K Moss, YL Lei, S Offenbache, S Zhang IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network J. Immunol., 2020-03-13;204(8):2177-2191. 2020-03-13 [PMID: 32169848] (Bioassay, Human)	Bioassay	Human
X Li, P Fang, Y Sun, Y Shao, WY Yang, X Jiang, H Wang, X Yang Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells Redox Biol, 2019-11-06;28(0):101373. 2019-11-06 [PMID: 31731100] (Bioassay, Human)	Bioassay	Human
N Ogasawara, JA Poposki, AI Klingler, BK Tan, KE Hulse, WW Stevens, AT Peters, LC Grammer, KC Welch, SS Smith, DB Conley, JR Raviv, P Soroosh, KI Takano, T Himi, RC Kern, RP Schleimer, A Kato Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps Mucosal Immunol, 2019-10-22;13(1):86-95. 2019-10-22 [PMID: 31641233] (Cell Culture, Human)	Cell Culture	Human
ER Wonderlich, K Subramania, B Cox, A Wiegand, C Lackman-Sm, MJ Bale, M Stone, R Hoh, MF Kearney, F Maldarelli, SG Deeks, MP Busch, RG Ptak, DA Kulpa Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals PLoS Pathog., 2019-10-14;15(10):e1008074. 2019-10-14 [PMID: 31609991] (Bioassay, Human)	Bioassay	Human
SK Horrevorts, DA Stolk, RV Ven, M Hulst, BVH Hof, S Duinkerken, MH Heineke, W Ma, SA Dusoswa, R Nieuwland, JJ Garcia-Val, AAV Loosdrecht, TD de Gruijl, SJV Vliet, Y van Kooyk Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination Cancers (Basel), 2019-08-28;11(9):. 2019-08-28 [PMID: 31466401] (Bioassay, Human)	Bioassay	Human
Y Ye, M Liu, L Tang, F Du, Y Liu, P Hao, Q Fu, Q Guo, Q Yan, X Zhang, C Bao Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis Arthritis Res. Ther., 2019-04-11;21(1):92. 2019-04-11 [PMID: 30971291] (Bioassay, Human)	Bioassay	Human
BA Kane, H An, P Rajasekari, HP McNeil, K Bryant, N Tedla Differential expression and regulation of the non-integrin 37/67-kDa laminin receptor on peripheral blood leukocytes of healthy individuals and patients with rheumatoid arthritis Sci Rep, 2019-02-04;9(1):1149. 2019-02-04 [PMID: 30718719] (Bioassay, Human)	Bioassay	Human
F Charbit-He, B Bègue, A Sierra, S Hanein, MC Stolzenber, Z Li, S Pellegrini, N Garcelon, M Jeanpierre, B Neven, I Loge, C Picard, J Rosain, J Bustamante, M Le Lorc'h, B Pigneur, A Fernandes, F Rieux-Lauc, J Amil Dias, FM Ruemmele, N Cerf-Bensu Copy number variations and founder effect underlying complete IL-10R? deficiency in Portuguese kindreds PLoS ONE, 2018-10-26;13(10):e0205826. 2018-10-26 [PMID: 30365510] (Bioassay, Human)	Bioassay	Human
AS Hansen, M Biltoft, B Bundgaard, AB Bohn, BK Møller, P Höllsberg CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells Cytokine, 2018-07-04;0(0):. 2018-07-04 [PMID: 29980471] (Bioassay, Human)	Bioassay	Human
EW Kim, RMB Teles, S Haile, PT Liu, RL Modlin Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae PLoS Negl Trop Dis, 2018-07-02;12(7):e0006608. 2018-07-02 [PMID: 29965969] (Bioassay, Human)	Bioassay	Human
SL Jaslow, KD Gibbs, WF Fricke, L Wang, KJ Pittman, MK Mammel, JT Thaden, VG Fowler, GE Hammer, JR Elfenbein, DC Ko Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10 Cell Rep, 2018-06-19;23(12):3525-3536. 2018-06-19 [PMID: 29924996] (Bioassay, Human)	Bioassay	Human
MK Hasan, J Yu, GF Widhopf, LZ Rassenti, L Chen, Z Shen, SP Briggs, DS Neuberg, TJ Kipps Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia Blood, 2018-04-20;0(0):. 2018-04-20 [PMID: 29678828] (Bioassay, Human)	Bioassay	Human
E Chen, G Liu, X Zhou, W Zhang, C Wang, D Hu, D Xue, Z Pan Concentration-dependent, dual roles of IL-10 in the osteogenesis of human BMSCs via P38/MAPK and NF-κB signaling pathways FASEB J., 2018-04-09;0(0):fj201701256RR. 2018-04-09 [PMID: 29630408] (Cell Culture, Human)	Cell Culture	Human
JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism Blood, 2018-03-01;0(0):. 2018-03-01 [PMID: 29496671] (Bioassay, Human)	Bioassay	Human
MW Tang, B Malvar Fer, SP Newsom, JD van Buul, TRDJ Radstake, DL Baeten, PP Tak, KA Reedquist, S García Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes Rheumatology (Oxford), 2018-05-01;0(0):. 2018-05-01 [PMID: 29471421] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
A Palazzo, S Herter, L Grosmaire, R Jones, CR Frey, F Limani, M Bacac, P Umana, RJ Oldham, MJE Marshall, KL Cox, AH Turaj, MS Cragg, C Klein, MJ Carter, S Tannheimer The PI3K?-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo J. Immunol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29453281] (Bioassay, Human)	Bioassay	Human
U Gopinathan, KR Redalen, AM Trøseid, P Kierulf, P Brandtzaeg, AH Ree, JP Berg, R Øvstebø Large-scale reduction of tyrosine kinase activities in human monocytes stimulated in vitro with N. meningitidis PLoS ONE, 2018-01-19;13(1):e0181912. 2018-01-19 [PMID: 29357362] (Bioassay, Human)	Bioassay	Human
RHP Wilbers, DR van Raaij, LB Westerhof, J Bakker, G Smant, A Schots Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain PLoS ONE, 2017-10-10;12(10):e0186317. 2017-10-10 [PMID: 29016674] (Bioassay, Mouse)	Bioassay	Mouse
X Li, P Lu, B Li, W Zhang, R Yang, Y Chu, K Luo Interleukin 2 and interleukin 10 function synergistically to promote CD8(+) T cell cytotoxicity, which is suppressed by regulatory T cells in breast cancer Int. J. Biochem. Cell Biol, 2017-03-06;0(0):. 2017-03-06 [PMID: 28274688] (Bioassay, Human)	Bioassay	Human
Anja Kerstein Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis J. Autoimmun, 2016-12-28;0(0):. 2016-12-28 [PMID: 28040323] (Bioassay, Human)	Bioassay	Human
Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling Sci Rep, 2016-12-19;6(0):39190. 2016-12-19 [PMID: 27991524] (Bioassay, Human)	Bioassay	Human
David M Aronoff Lipid profiling of polarized human monocyte-derived macrophages Prostaglandins Other Lipid Mediat., 2016-11-15;127(0):1-8. 2016-11-15 [PMID: 27871801] (Bioassay, Human)	Bioassay	Human
PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells Sci Rep, 2016-11-09;6(0):36795. 2016-11-09 [PMID: 27827428] (Bioassay, Human)	Bioassay	Human
Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation PLoS ONE, 2016-11-03;11(11):e0165909. 2016-11-03 [PMID: 27812183] (Bioassay, Human)	Bioassay	Human
Tyrosine kinase 2 is not limiting human antiviral type III interferon responses Eur J Immunol, 2016-10-05;0(0):. 2016-10-05 [PMID: 27615517] (Bioassay, Human)	Bioassay	Human
Andreani G, Ouellet M, Menasria R, Gomez A, Barat C, Tremblay M Leishmania infantum amastigotes trigger a subpopulation of human B cells with an immunoregulatory phenotype. PLoS Negl Trop Dis, 2015-02-24;9(2):e0003543. 2015-02-24 [PMID: 25710789] (Bioassay, Human)	Bioassay	Human
Reiner A, Heldt S, Presley C, Guley N, Elberger A, Deng Y, D'Surney L, Rogers J, Ferrell J, Bu W, Del Mar N, Honig M, Gurley S, Moore B Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189. Int J Mol Sci, 2014-12-31;16(1):758-87. 2014-12-31 [PMID: 25561230] (Bioassay, Human)	Bioassay	Human
Kim H, Yun J, Shin T, Lee S, Lee B, Yu K, Seo Y, Lee S, Kang T, Choi S, Seo K, Kang K Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-beta1 alleviate atopic dermatitis by reducing mast cell degranulation. Stem Cells, 2015-04-01;33(4):1254-66. 2015-04-01 [PMID: 25522163] (Bioassay, Human)	Bioassay	Human
Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development. Cancer Res, 2014-12-09;75(2):306-15. 2014-12-09 [PMID: 25492861] (Bioassay, Human)	Bioassay	Human
Cheng , DA-En, Tsai , Ying-Min, Hsu , Ya-Ling, Hou , Ming-Fen, Tsai , Eing-Mei, Wang , Jaw-Yuan, Kan , Jung-Yu, Kuo , Po-Lin Cluster of differentiation 45 activation is crucial in interleukin-10-dependent tumor-associated dendritic cell differentiation. Oncol Lett, 2014-05-19;8(2):620-626. 2014-05-19 [PMID: 25013476] (Bioassay, Human)	Bioassay	Human
Osorio E, Travi B, da Cruz A, Saldarriaga O, Medina A, Melby P Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis. PLoS Pathog, 2014-06-26;10(6):e1004165. 2014-06-26 [PMID: 24967908] (Bioassay, Hamster)	Bioassay	Hamster
Anuradha R, George P, Hanna L, Kumaran P, Chandrasekaran V, Nutman T, Babu S Expansion of parasite-specific CD4+ and CD8+ T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic filariasis. PLoS Negl Trop Dis, 2014-04-03;8(4):e2762. 2014-04-03 [PMID: 24699268] (Bioassay, Human)	Bioassay	Human
Karahan G, Eikmans M, Anholts J, Claas F, Heidt S Polyclonal B cell activation for accurate analysis of pre-existing antigen-specific memory B cells. Clin Exp Immunol, 2014-07-01;177(1):333-40. 2014-07-01 [PMID: 24611883] (Bioassay, Human)	Bioassay	Human
O'Reilly S, Ciechomska M, Cant R, van Laar J Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein. J Biol Chem, 2014-02-18;289(14):9952-60. 2014-02-18 [PMID: 24550394] (Bioassay, Human)	Bioassay	Human
Valle Oseguera , Cendy A, Spencer , Juliet V cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells. PLoS ONE, 2014-02-10;9(2):e88708. 2014-02-10 [PMID: 24520416] (Bioassay, Human)	Bioassay	Human
Italiani , Paola, Mazza , Emilia M, Lucchesi , Davide, Cifola , Ingrid, Gemelli , Claudia, Grande , Alexis, Battaglia , Cristina, Bicciato , Silvio, Boraschi , Diana Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro. PLoS ONE, 2014-02-03;9(2):e87680. 2014-02-03 [PMID: 24498352] (Bioassay, Human)	Bioassay	Human
McCutcheon , Krista M, Gray , Julia, Chen , Natalie, Liu , Keyi, Park , Minha, Ellsworth , Stote, Tripp , Ralph A, Tompkins , S Mark, Johnson , Scott K, Samet , Shelly, Pereira , Lenore, Kauvar , Lawrence Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets. MAbs, 2014-01-08;6(2):460-73. 2014-01-08 [PMID: 24492306] (Bioassay, Human)	Bioassay	Human
Du M, Guo P, Piao H, Wang S, Sun C, Jin L, Tao Y, Li Y, Zhang D, Zhu R, Fu Q, Li D Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells. J Immunol, 2014-01-22;192(4):1502-11. 2014-01-22 [PMID: 24453244] (Bioassay, Human)	Bioassay	Human
Hamada , Michito, Nakamura , Megumi, Tran , Mai Thi, Moriguchi , Takashi, Hong , Cynthia, Ohsumi , Takayuki, Dinh , Tra Thi, Kusakabe , Manabu, Hattori , Motochik, Katsumata , Tokio, Arai , Satoko, Nakashima , Katsuhik, Kudo , Takashi, Kuroda , Etsushi, Wu , Chien-Hu, Kao , Pei-Han, Sakai , Masaharu, Shimano , Hitoshi, Miyazaki , Toru, Tontonoz , Peter, Takahashi , Satoru MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun, 2014-01-01;5(0):3147. 2014-01-01 [PMID: 24445679] (Bioassay, Human)	Bioassay	Human
Garcia S, Krausz S, Ambarus C, Fernandez B, Hartkamp L, van Es I, Hamann J, Baeten D, Tak P, Reedquist K Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype. PLoS ONE, 2014-01-03;9(1):e82088. 2014-01-03 [PMID: 24404127] (Bioassay, Human)	Bioassay	Human
Suzuki , Hitoshi, Raska , Milan, Yamada , Koshi, Moldoveanu , Zina, Julian , Bruce A, Wyatt , Robert J, Tomino , Yasuhiko, Gharavi , Ali G, Novak , Jan Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J Biol Chem, 2014-01-07;289(8):5330-9. 2014-01-07 [PMID: 24398680] (Bioassay, Human)	Bioassay	Human
Gonzalez-Lombana C, Gimblet C, Bacellar O, Oliveira W, Passos S, Carvalho L, Goldschmidt M, Carvalho E, Scott P IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection. PLoS Pathog, 2013-03-21;9(3):e1003243. 2013-03-21 [PMID: 23555256] (Bioassay, Human)	Bioassay	Human
Verjee L, Verhoekx J, Chan J, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood K, Nanchahal J Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target. Proc Natl Acad Sci U S A, 2013-02-19;110(10):E928-37. 2013-02-19 [PMID: 23431165] (Bioassay, Human)	Bioassay	Human
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol, 2013-02-10;131(4):1146-56, 1156. 2013-02-10 [PMID: 23403044] (Bioassay, Human)	Bioassay	Human
Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis. Hum Mol Genet, 2013-01-31;22(9):1807-15. 2013-01-31 [PMID: 23376980] (Bioassay, Human)	Bioassay	Human
Martinez-Gallo M, Radigan L, Almejun M, Martinez-Pomar N, Matamoros N, Cunningham-Rundles C TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes. J Allergy Clin Immunol, 2012-12-11;131(2):468-76. 2012-12-11 [PMID: 23237420] (Bioassay, Human)	Bioassay	Human
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation. PLoS Biol, 2012-09-25;10(9):e1001395. 2012-09-25 [PMID: 23055831] (Bioassay, Human)	Bioassay	Human
Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE, 2012-10-01;7(10):e46117. 2012-10-01 [PMID: 23049692] (Bioassay, Human)	Bioassay	Human
Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J. Exp. Med., 2012-09-17;209(10):1813-23. 2012-09-17 [PMID: 22987802] (Bioassay, Human)	Bioassay	Human
Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, Feizi T, Kim SK, Sobieszczuk P, Willment JA, Brown GD The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase. J. Biol. Chem., 2012-06-11;287(31):25964-74. 2012-06-11 [PMID: 22689578] (Bioassay, Human)	Bioassay	Human
Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J. Immunol., 2012-03-14;188(8):3745-56. 2012-03-14 [PMID: 22422881] (Bioassay, Human)	Bioassay	Human
Liu X, Yang P, Wang C, Li F, Kijlstra A IFN-alpha blocks IL-17 production by peripheral blood mononuclear cells in Behcet's disease. Rheumatology (Oxford), 2010-11-08;50(2):293-8. 2010-11-08 [PMID: 21059671] (Bioassay, Human)	Bioassay	Human
Ghigo E, Barry AO, Pretat L, Al Moussawi K, Desnues B, Capo C, Kornfeld H, Mege JL IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation. PLoS ONE, 2010-10-21;5(10):e13561. 2010-10-21 [PMID: 21042409] (Bioassay, Human)	Bioassay	Human
Kalliolias GD, Gordon RA, Ivashkiv LB Suppression of TNF-alpha and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27. J. Immunol., 2010-10-22;185(11):7047-56. 2010-10-22 [PMID: 20971923] (Bioassay, Human)	Bioassay	Human
Ghirelli C, Zollinger R, Soumelis V Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells. Blood, 2010-04-09;115(24):5037-40. 2010-04-09 [PMID: 20382843] (Bioassay, Human)	Bioassay	Human
Liang X, Moseman EA, Farrar MA Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood, 2010-03-25;115(24):5041-52. 2010-03-25 [PMID: 20339095] (Bioassay, Human)	Bioassay	Human
Maarof G, Bouchet-Delbos L, Gary-Gouy H, Durand-Gasselin I, Krzysiek R, Dalloul A Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells. Blood, 2009-11-24;115(9):1718-26. 2009-11-24 [PMID: 19965640] (Bioassay, Human)	Bioassay	Human
Jindra C Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol, 2010-02-01;40(2):321-9. 2010-02-01 [PMID: 19950173] (Bioassay, Human)	Bioassay	Human
Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol. Lett., 2009-11-04;127(2):150-6. 2009-11-04 [PMID: 19895848] (ELISA (Standard))	ELISA (Standard)
Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ PEGylation of interleukin-10 for the mitigation of enhanced pain states. J Biomed Mater Res A, 2010-06-01;93(3):1169-79. 2010-06-01 [PMID: 19768789] (Bioassay, In Vivo, Mouse, Rat)	Bioassay, In Vivo	Mouse, Rat
Park-Min KH, Ji JD, Antoniv T, Reid AC, Silver RB, Humphrey MB, Nakamura M, Ivashkiv LB IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression. J. Immunol., 2009-07-22;183(4):2444-55. 2009-07-22 [PMID: 19625651] (Bioassay, Human)	Bioassay	Human
Chang WL, Barry PA, Szubin R, Wang D, Baumgarth N Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog. Virology, 2009-06-13;390(2):330-7. 2009-06-13 [PMID: 19524994] (Bioassay, Human)	Bioassay	Human
Shahrara S, Pickens SR, Dorfleutner A, Pope RM IL-17 induces monocyte migration in rheumatoid arthritis. J. Immunol., 2009-03-15;182(6):3884-91. 2009-03-15 [PMID: 19265168] (Bioassay, Human)	Bioassay	Human
Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86. 2008-12-03 [PMID: 19056108] (Bioassay, Human)	Bioassay	Human
Hirosako S, Goto E, Fujii K, Tsumori K, Hirata N, Tsumura S, Kamohara H, Kohrogi H Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells. Clin. Exp. Immunol., 2008-11-26;155(2):266-74. 2008-11-26 [PMID: 19040600] (Bioassay, Human)	Bioassay	Human
Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J. Immunol., 2008-08-15;181(4):2772-80. 2008-08-15 [PMID: 18684968] (Bioassay, Human)	Bioassay	Human
Rojahn A, Brusletto B, Ovstebo R, Haug KB, Kierulf P, Brandtzaeg P Does granulocyte colony-stimulating factor ameliorate the proinflammatory response in human meningococcal septic shock? Crit. Care Med., 2008-09-01;36(9):2583-9. 2008-09-01 [PMID: 18679115] (Bioassay, Human)	Bioassay	Human
Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, O'Shea MA, Roby G, Kottilil S, Arthos J, Proschan MA, Chun TW, Fauci AS Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J. Exp. Med., 2008-07-14;205(8):1797-805. 2008-07-14 [PMID: 18625747] (Bioassay, Human)	Bioassay	Human
van der Vliet HJ, Wang R, Yue SC, Koon HB, Balk SP, Exley MA Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. J. Immunol., 2008-06-01;180(11):7287-93. 2008-06-01 [PMID: 18490728] (Bioassay, Human)	Bioassay	Human
Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392. 2008-04-14 [PMID: 18410958] (Bioassay, Human)	Bioassay	Human
Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells. Eur. J. Immunol., 2008-04-01;38(4):1012-23. 2008-04-01 [PMID: 18350544] (Bioassay, Human)	Bioassay	Human
Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J. Clin. Invest., 2007-07-01;117(7):1951-60. 2007-07-01 [PMID: 17557119] (Bioassay, Human)	Bioassay	Human
Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS, 2007;21(10):1263-72. 2007 [PMID: 17545702] (ELISA (Standard), N/A)	ELISA (Standard)	N/A
Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J. Immunol., 2007-03-01;178(5):2872-82. 2007-03-01 [PMID: 17312131] (Bioassay, Human)	Bioassay	Human
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard))	ELISA (Standard)
Gleissner CA, Zastrow A, Klingenberg R, Kluger MS, Konstandin M, Celik S, Haemmerling S, Shankar V, Giese T, Katus HA, Dengler TJ IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Eur. J. Immunol., 2007-01-01;37(1):177-92. 2007-01-01 [PMID: 17163451] (Bioassay, Human)	Bioassay	Human
Wan B, Nie H, Liu A, Feng G, He D, Xu R, Zhang Q, Dong C, Zhang JZ Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J. Immunol., 2006-12-15;177(12):8844-50. 2006-12-15 [PMID: 17142787] (Bioassay, Human)	Bioassay	Human
Venet F, Pachot A, Debard AL, Bohe J, Bienvenu J, Lepape A, Powell WS, Monneret G Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. J. Immunol., 2006-11-01;177(9):6540-7. 2006-11-01 [PMID: 17056586] (Bioassay, Human)	Bioassay	Human
Du Z, Kelly E, Mecklenbrauker I, Agle L, Herrero C, Paik P, Ivashkiv LB Selective regulation of IL-10 signaling and function by zymosan. J. Immunol., 2006-04-15;176(8):4785-92. 2006-04-15 [PMID: 16585572] (ELISA (Standard))	ELISA (Standard)
Hsieh FH, Sharma P, Gibbons A, Goggans T, Erzurum SC, Haque SJ Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc. Natl. Acad. Sci. U.S.A., 2005-09-26;102(40):14380-5. 2005-09-26 [PMID: 16186496] (Bioassay, Human)	Bioassay	Human
Fujitsu Y, Fukuda K, Kimura K, Seki K, Kumagai N, Nishida T Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13. Invest. Ophthalmol. Vis. Sci., 2005-03-01;46(3):797-802. 2005-03-01 [PMID: 15728533] (Bioassay, Human)	Bioassay	Human
Pound JD, Batth BK, Johannessen I, Wood K Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma. J. Immunol., 2005-03-01;174(5):3015-23. 2005-03-01 [PMID: 15728515] (Bioassay, Human)	Bioassay	Human
Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC trans fatty acids and systemic inflammation in heart failure. Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5. 2004-12-01 [PMID: 15585763] (ELISA (Standard))	ELISA (Standard)
Gibot S, Kolopp-Sarda MN, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med., 2004-11-22;200(11):1419-26. 2004-11-22 [PMID: 15557347] (Bioassay, Human)	Bioassay	Human
Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)	Bioassay	Human
Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)	Bioassay	Human
Chang WL, Baumgarth N, Yu D, Barry PA Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality. J. Virol., 2004-08-01;78(16):8720-31. 2004-08-01 [PMID: 15280480] (Bioassay, Human)	Bioassay	Human
Phillips TM Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis, 2004-06-01;25(10):1652-9. 2004-06-01 [PMID: 15188254]
Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J. Immunol., 2004-05-15;172(10):6476-81. 2004-05-15 [PMID: 15128840] (Bioassay, Human)	Bioassay	Human
Moreaux J, Legouffe E, Jourdan E, Quittet P, Reme T, Lugagne C, Moine P, Rossi JF, Klein B, Tarte K BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone. Blood, 2003-12-04;103(8):3148-57. 2003-12-04 [PMID: 15070697] (Bioassay, Human)	Bioassay	Human
Copeland S, Siddiqui J, Remick D Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-01-01;284(1):99-106. 2004-01-01 [PMID: 14736420] (ELISA (Standard))	ELISA (Standard)
Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, Matsushita I, Seymour JF, Oh-Eda M, Ishige I, Eishi Y, Kitamura T, Yamada Y, Hanaoka K, Keicho N High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood, 2003-09-25;103(3):1089-98. 2003-09-25 [PMID: 14512323] (SDS-Page, Human)	SDS-Page	Human
Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo. J. Leukoc. Biol., 2003-07-22;74(5):880-8. 2003-07-22 [PMID: 12960279] (Control)	Control
Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A., 2003-07-23;100(16):9452-7. 2003-07-23 [PMID: 12878725] (Bioassay, Human)	Bioassay	Human
Gasche C, Grundtner P, Zwirn P, Reinisch W, Shaw SH, Zdanov A, Sarma U, Williams LM, Foxwell BM, Gangl A Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production. J. Immunol., 2003-06-01;170(11):5578-82. 2003-06-01 [PMID: 12759436] (Bioassay, Human)	Bioassay	Human
Gee K, Lim W, Ma W, Nandan D, Diaz-Mitoma F, Kozlowski M, Kumar A Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression. J. Immunol., 2002-11-15;169(10):5660-72. 2002-11-15 [PMID: 12421945] (Bioassay, ELISA (Standard), Human)	Bioassay, ELISA (Standard)	Human
Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56. 2002-05-01 [PMID: 11943670] (Bioassay, Human)	Bioassay	Human
Drouet M, 49153, Mathieu J, Grenier N, Multon E, Sotto JJ, Herodin F The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation. Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance, 1999-01-01;17(5):273-85. 1999-01-01 [PMID: 10527462] (Bioassay, Primate - Papio anubis (Olive Baboon))	Bioassay	Primate - Papio anubis (Olive Baboon)
Fadok , V A, Bratton , D L, Konowal , A, Freed , P W, Westcott , J Y, Henson , P M Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest, 1998-02-15;101(4):890-8. 1998-02-15 [PMID: 9466984] (Bioassay, Human)	Bioassay	Human
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Array 217-IL

• IL-10 Antibodies
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• IL-10 Proteins
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