Recombinant Human IFN-gamma R1/CD119 Avi-tag His Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon gamma receptor 1 (IFNGR1), along with IFNGR2, are type II cytokine receptors that combine to form a high affinity signaling complex with the type II interferon, IFNG. Mature human IFNGR1 consists of an extracellular domain (ECD) with 2 Ig-like domains, a transmembrane domain and an intracellular domain with both Jak1 and Stat1 binding motifs. The ECD of human IFNGR1 shares 50% amino acid sequence identity with mouse IFNGR1. The IFNG signaling complex is formed by 2 IFNGR1 subunits binding one IFNG dimer directly, and then 2 IFNGR2 molecules further stabilizing the receptor complex. Complex formation then triggers a signaling cascade that culminates in the transcription of the interferon stimulated genes (ISGs) and additional transcription factors. Ultimately, IFNGR1 mediated signaling regulates several biological processes including innate and acquired immune response, apoptosis and cell cycle progression. IFNGR1 is constitutively expressed in most cell types and deletions or mutations to IFNGR1 result in reduced resistance to bacterial, parasitic, and viral infection. Our Avi-tag Biotinylated IFNGR1 features biotinylation at a single site contained within the Avi-tag, a unique 15 amino acid peptide. Protein orientation will be uniform when bound to streptavidin-coated surface due to the precise control of biotinylation and the rest of the protein is unchanged so there is no interference in the protein's bioactivity.

Array AVI11030

• IFN-gamma R1/CD119 Antibodies
• IFN-gamma R1/CD119 Antibody Pair
• IFN-gamma R1/CD119 ELISA Kit
• IFN-gamma R1/CD119 Lysate
• IFN-gamma R1/CD119 Protein
• IFN-gamma R1/CD119 ELISA
• IFN-gamma R1/CD119 Proteins and Enzymes