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Recombinant Human FGF-18 Protein, CF

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Recombinant Human FGF-18 (Catalog # 8988-F18) induces cell proliferation of the Baf3mouse pro-B cells transfected with human FGF RIIIc. The ED50for this effect is 4-24 ng/mL.
Recombinant Human FGF-18 (Catalog # 8988-F18) induces cell proliferation of the Baf3mouse pro-B cells transfected with human FGF RIIIc. The ED50for this effect is 4-24 ng/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Human FGF-18 Protein, CF Summary

Details of Functionality
Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human FGF RIIIc. The ED50 for this effect is 4-24 ng/mL
Source
E. coli-derived human FGF-18 protein
Glu28-Ala207, with a N-terminal Met
Accession #
N-terminal Sequence
Met
Protein/Peptide Type
Recombinant Proteins
Gene
FGF18
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
21 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
19-24 kDa, reducing conditions
Publications
Read Publications using
8988-F18 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4, EDTA and Trehalose.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 500 μg/mL in water.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human FGF-18 Protein, CF

  • FGF18
  • FGF-18
  • FGF-18ZFGF5
  • fibroblast growth factor 18
  • zFGF5

Background

Fibroblast Growth Factor 18 (FGF-18) is a 20 kDa protein that plays an important role in skeletal development and bone homeostasis (1). Mature human FGF-18 shares 99% amino acid sequence identity with mouse and rat FGF-18 (2). It is expressed in embryonic somites and the neural fold (3), adult lung (2), cerebellar and hippocampal neurons (4), hair follicle root sheath cells (5), and osteogenic mesenchymal cells (6). FGF-18 binds to FGF R2c, FGF R3c (4, 7) as well as the Golgi protein GLG1 (8) and induces the proliferation of astrocytes and microglia, vascular endothelial cells, dermal fibroblasts, papilla cells, and keratinocytes (4, 5, 9). FGF-18 is required for normal skeletal development (6). It recruits osteoclasts and osteoblasts to the growth plate, promotes osteoclast formation and function, inhibits osteoblast differentiation, promotes skeletal vascularization, and induces chondrocyte hypertrophy and cartilage matrix formation (6, 7, 10, 11).
  1. Beenken, A. and M. Mohammadi (2009) Nat. Rev. Drug Discov. 8:235.
  2. Ohbayashi, N. et al. (1998) J. Biol. Chem. 273:18161.
  3. Ohuchi, H. et al. (2000) Mech. Dev. 95:55.
  4. Hoshikawa, M. et al. (2002) Brain Res. Mol. Brain Res. 105:60.
  5. Kawano, M. et al. (2005) J. Invest. Dermatol. 124:877.
  6. Ohbayashi, N. et al. (2002) Genes Dev. 16:870.
  7. Davidson, D. et al. (2005) J. Biol. Chem. 280:20509.
  8. Miyaoka, Y. et al. (2010) Development 137:159.
  9. Hu, M.C. et al. (1998) Mol. Cell. Biol. 18:6063.
  10. Liu, Z. et al. (2007) Dev. Biol. 302:80.
  11. Shimoaka, T. et al. (2002) J. Biol. Chem. 277:7493.

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Recombinant Human
FGF-18 Protein, CF
8988-F18
Recombinant Human FGF-18 Protein, CF
Species: Hu
Applications: Bioactivity

Publications for FGF18 (8988-F18)(3)

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: Cell Culture, In Vivo.


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(1)
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(2)
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Bioinformatics

Gene Symbol FGF18
Uniprot