FGFR2 Antibody (1G3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using H00002263-M01	Applications	Species
Kamil M, Kamila K, Marcin B et al. FGF7/FGFR2-JunB signalling counteracts the effect of progesterone in luminal breast cancer. Mol Oncol. 2022-06-20 [PMID: 35726195]
Marcin B, Dominika P, Mateusz B et al. A 'Real-Life' Experience on Automated Digital Image Analysis of FGFR2 Immunohistochemistry in Breast Cancer. Diagnostics (Basel). 2020-12-07 [PMID: 33297384]
Turczyk L, Kitowska K, Mieszkowska M et al. FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ER?-Positive Breast Cancer Cells. Neoplasia. 2017-09-01 [PMID: 28869838]
Czaplinska D, Mieczkowski K, Supernat A et al. Interactions between FGFR2 and RSK2-implications for breast cancer prognosis. Tumour Biol 2016-07-30 [PMID: 27476168]
Akizawa H, Nagatomo H, Odagiri H et al. Conserved roles of fibroblast growth factor receptor 2 signaling in the regulation of inner cell mass development in bovine blastocysts. Mol Reprod Dev 2016-06-01 [PMID: 27060901]
Yoon G, Lee H, Kim JH et al. Clinical significance of fibroblast growth factor receptor 2 expression in patients with residual rectal cancer after preoperative chemoradiotherapy: relationship with KRAS or BRAF mutations and MSI status. Tumour Biol 2016-01-30 [PMID: 26831663]
Lee HJ, Kang HJ, Kim KM et al. Fibroblast growth factor receptor isotype expression and its association with overall survival in patients with hepatocellular carcinoma. Clin Mol Hepatol 2015-03-01 [PMID: 25834803] (IF/IHC, Human)	IF/IHC	Human
Grygielewicz P, Dymek B, Bujak A et al. Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells. Gastric Cancer. 2014-11-19 [PMID: 25407459]
Cazet A, Charest J, Bennett DC et al. Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity. PLoS One. 2014-10-14 [PMID: 25314669]
Lee HJ, Seo AN, Park SY et al. Low Prognostic Implication of Fibroblast Growth Factor Family Activation in Triple-negative Breast Cancer Subsets. Ann Surg Oncol. 2014-01-03 [PMID: 24385208]
Katano H, Yamada K, et al. Upregulation of ANGPTL4 Messenger RNA and Protein in Severely Calcified Carotid Plaques. J Stroke Cerebrovasc Dis 2013-09-26 [PMID: 24075588]
Vermeulen JF, Kornegoor R, van der Wall E et al. Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer. PLoS One. 2013-01-04 [PMID: 23308200]
Ozawa M, Yang QE, Ealy AD. The expression of fibroblast growth factor receptors during early bovine conceptus development and pharmacological analysis of their actions on trophoblast growth in vitro. Reproduction. 2013-01-24 [PMID: 23241344]
Show All 13 Publications. Collapse Publications.

Array H00002263-M01

• FGFR2 Antibodies
• FGFR2 Antibody Pair
• FGFR2 ELISA Kit
• FGFR2 Lysates
• FGFR2 Proteins