Recombinant Human DEC-205/CD205 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

DEC-205, also known as CD205 and lymphocyte antigen 75 (Ly75), is a type I transmembrane protein that is part of the macrophage mannose receptor (MMR) family of C-type lectins (1). Both the human and mouse proteins share a similar extracellular (ECD) structure consisting of a cysteine rich N-terminal domain, a fibronectin type II domain, and multiple C-type lectin-like domains (1, 2). The mature ECD of human DEC-205 shares 68% amino acid (aa) identity with mouse DEC‑205. DEC‑205 is primarily expressed on dendritic cells (DC) of lymphoid tissues and at lower levels on macrophages and T cells (3, 4). DEC-205 functions as an endocytic receptor for antigens (3, 4). DEC-205 was shown to be a a cell surface receptor for CpG-oligonucleotides (ODN), as mice deficient in DEC-205 have impaired DC and B-cell maturation (5). DEC-205 expressing Kupffer stellate macrophage cells in the liver responded to CpG-ODN and subsequently released cytokines to promote NKT cell activation, leading to liver damage (6). DEC-205 also recognizes apoptotic and necrotic cells by binding to keratin in a pH-dependent fashion, leading to either immune activation or tolerance in the absence or presence of inflammatory stimuli (7, 8). DEC-205 positive macrophages in the human gastric mucosa were shown to mediate local and systemic immune responses to H. pylori infection, which affects systemic immunity (9). DEC-205 was also found to exist as an intergenic splice variant able to form a fusion protein with CD302 in Hodgkin's lymphoma cell lines (10). The DEC-205/CD302 fusion protein was also found to be expressed by mature dendritic cells which altered endocytic capacity of DEC-205, although the wild-type single gene transcripts were the dominant isoforms expressed (11). DEC-205 has been widely used in immune therapies for vaccine generation. Targeting of antigens to DEC-205 resulted in enhanced antigen presentation by DC. In combination with adjuvants, proteins coupled to antibodies against DEC-205 induced strong pathogen-specific immune responses, while without additional adjuvant tolerance could be induced (12).

Array 10205-DE

• DEC-205/CD205 Antibodies
• DEC-205/CD205 Proteins
• DEC-205/CD205 Proteins and Enzyme