Recombinant Human CTGF/CCN2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a 36-38 kDa member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins (1). Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain (2). Human CTGF shares 94% amino acid (aa) sequence identity with mouse and rat CTGF. Alternative splicing generates an additional isoform with a 27 aa deletion within the TSP-1 domain. CTGF promotes cell adhesion through interactions with a range of cell surface molecules including heparan sulfate proteoglycans (HSPG), LRPAP, and Integrins  alpha M, alpha V beta 3, alpha 6 beta 1, alpha IIb beta 3 (3-7). It also binds to and regulates signaling through the Wnt receptors LRP6 and Frizzled-8 and the NGF receptors TrkA and NGF R (8, 9). In addition, CTGF binds directly to BMP-4, TGF-beta 1, TGF-beta 2, and VEGF 165 (10, 11). It blocks BMP-4 and VEGF induced responses but enhances TGF-beta induced responses (10-13). Within VEGF complexes, CTGF can be degraded by a variety of proteases, resulting in restoration of angiogenic activity (11). CTGF promotes fibroblast differentiation from mesenchymal stem cells and their production of type I Collagen and Tenascin C (5, 14). It promotes chondrocyte proliferation and cartilage matrix synthesis (15-17). CTGF is expressed in vascular mural and endothelial cells (EC) during development and promotes pericyte-EC association and angiogenesis (2, 17, 18, 19). It is expressed in the cerebral cortex and olfactory bulb and plays an important role in nervous system development (8, 12).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Bioassay, ELISA Standard, Western Blot Control.

Showing Publications 1 - 8 of 8.

Publications using 9190-CC	Applications	Species
Y Wang, X Liu, Q Xu, W Xu, X Zhou, Z Lin CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development JCI Insight, 2023-01-10;8(1):. 2023-01-10 [PMID: 36625347] (Bioassay, Human)	Bioassay	Human
T Nakayama, T Azegami, K Hayashi, A Hishikawa, N Yoshimoto, R Nakamichi, E Sugita, H Itoh Vaccination against connective tissue growth factor attenuates the development of renal fibrosis Scientific Reports, 2022-06-29;12(1):10933. 2022-06-29 [PMID: 35768626] (Western Blot Control, Human)	Western Blot Control	Human
C He, B Jiang, M Wang, P Ren, SI Murtada, AW Caulk, G Li, L Qin, R Assi, CJ Lovoulos, MA Schwartz, JD Humphrey, G Tellides mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice JCI Insight, 2022-02-08;7(3):. 2022-02-08 [PMID: 35132962] (Bioassay, Mouse)	Bioassay	Mouse
A Soundarara, SA Ghag, SS Vuda, T Wang, PP Pattabiram Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway Cells, 2021-10-24;10(11):. 2021-10-24 [PMID: 34831087] (Bioassay, Human)	Bioassay	Human
L Simoni, J Presumey, CE van der Po, C Castrillon, SE Chang, PJ Utz, MC Carroll Complement C4A Regulates Autoreactive B Cells in Murine Lupus Cell Rep, 2020-11-03;33(5):108330. 2020-11-03 [PMID: 33147456] (ELISA Standard, Human)	ELISA Standard	Human
JW Hellinger, F Schömel, JV Buse, C Lenz, G Bauerschmi, G Emons, C Gründker Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling Sci Rep, 2020-10-21;10(1):17889. 2020-10-21 [PMID: 33087801] (Bioassay, Human)	Bioassay	Human
T Muraguchi, D Nanba, EK Nishimura, T Tashiro IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance J. Dermatol. Sci., 2019-05-11;0(0):. 2019-05-11 [PMID: 31122679] (Bioassay, Human)	Bioassay	Human
AP Mann, P Scodeller, S Hussain, GB Braun, T Mölder, K Toome, R Ambasudhan, T Teesalu, SA Lipton, E Ruoslahti Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease Nat Commun, 2017-11-10;8(1):1403. 2017-11-10 [PMID: 29123083] (Bioassay)	Bioassay

Array 9190-CC

• CTGF/CCN2 Antibodies
• CTGF/CCN2 ELISA Kits
• CTGF/CCN2 Lysate
• CTGF/CCN2 Proteins
• CTGF/CCN2 Proteins and Enzymes
• CTGF/CCN2 ELISA