Recombinant Human Axl Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. TAM family receptors (Dtk/Tyro3, Axl, and Mer) are involved in regulation of the inflammatory response, cell survival and migration, and tumorigenesis (1). Mature human Axl consists of a 426 aa extracellular domain (ECD) that contains two Ig-like domains and two fibronectin type III domains, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain that includes the tyrosine kinase domain (2). Within the ECD, human Axl shares approximately 82% aa sequence identity with mouse and rat Axl. A short alternately spliced form of human Axl has a 9 aa deletion in the extracellular juxtamembrane region (2). Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain (3). Activation of Axl induces a broad range of activities including platelet aggregation and thrombus formation (4), macrophage and dendritic cell phagocytosis of apoptotic cells (5), NK cell development from hematopoietic progenitor cells (6), and in vivo angiogenesis (7). Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness (7, 8). It contributes to vascular remodeling and inflammatory cell infiltration in response to hypertension and restricted blood flow (9). It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses (10). A 70-80 kDa soluble portion of the Axl ECD can be shed by proteolytic cleavage, and this fragment retains the ability to bind Gas6 (11, 12).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Binding Assay, Bioassay, CAR-T, SPR.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using 154-AL	Applications	Species
CA Hokanson, E Zacco, G Cappuccill, T Odineca, R Crea AXL-Receptor Targeted 14FN3 Based Single Domain Proteins (Pronectins�) from 3 Synthetic Human Libraries as Components for Exploring Novel Bispecific Constructs against Solid Tumors Biomedicines, 2022-12-08;10(12):. 2022-12-08 [PMID: 36551940] (Bioassay, Mouse)	Bioassay	Mouse
F Wanke, S Gutbier, A Rümmelin, M Steinberg, LD Hughes, M Koenen, J Komuczki, D Regan-Komi, S Wagage, J Hesselmann, R Thoma, D Brugger, T Christopei, H Wang, F Point, R Hallet, S Ghosh, CV Rothlin, C Patsch, B Geering Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages Cell Death & Disease, 2021-05-25;12(6):538. 2021-05-25 [PMID: 34035216] (SPR, Human)	SPR	Human
G Luthria, R Li, S Wang, M Prytyskach, RH Kohler, DA Lauffenbur, TJ Mitchison, R Weissleder, MA Miller In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells Nat Commun, 2020-07-14;11(1):3521. 2020-07-14 [PMID: 32665556] (Bioassay, Human)	Bioassay	Human
SJ Wang, R Li, TSC Ng, G Luthria, MJ Oudin, M Prytyskach, RH Kohler, R Weissleder, DA Lauffenbur, MA Miller Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy Sci Adv, 2020-05-22;6(21):eaaz8521. 2020-05-22 [PMID: 32494745] (Bioassay, Human)	Bioassay	Human
PY Dumas, C Naudin, S Martin-Lan, B Izac, L Casetti, O Mansier, B Rousseau, A Artus, M Dufossée, A Giese, P Dubus, A Pigneux, V Praloran, A Bidet, A Villacrece, AV Guitart, N Milpied, O Kosmider, I Vigon, V Desplat, I Dusanter-F, JM Pasquet Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL Haematologica, 2019-03-28;0(0):. 2019-03-28 [PMID: 30923103] (Bioassay, Human)	Bioassay	Human
Cho J, Okuma A, Al-Rubaye D, Intisar E, Junghans R, Wong W Engineering Axl specific CAR and SynNotch receptor for cancer therapy. Sci Rep, 2018-03-01;8(1):3846. 2018-03-01 [PMID: 29497107] (CAR-T, Human)	CAR-T	Human
Park I, Mundy-Bosse B, Whitman S, Zhang X, Warner S, Bearss D, Blum W, Marcucci G, Caligiuri M Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia. Leukemia, 2015-06-19;29(12):2382-9. 2015-06-19 [PMID: 26172401] (Bioassay, Human)	Bioassay	Human
Zizzo G, Guerrieri J, Dittman L, Merrill J, Cohen P Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther, 2013-01-01;15(6):R212. 2013-01-01 [PMID: 24325951] (Human)		Human
Cerchia , Laura, Esposito , Carla L, Camorani , Simona, Rienzo , Anna, Stasio , Loredana, Insabato , Luigi, Affuso , Andrea, de Franciscis , Vittorio Targeting Axl with an high-affinity inhibitory aptamer. Mol Ther, 2012-08-21;20(12):2291-303. 2012-08-21 [PMID: 22910292] (Bioassay, Human)	Bioassay	Human
Ruan GX, Kazlauskas A Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J., 2012-02-10;31(7):1692-703. 2012-02-10 [PMID: 22327215] (Bioassay, Human)	Bioassay	Human
Shimojima M, Stroher U, Ebihara H, Feldmann H, Kawaoka Y Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. J. Virol., 2011-12-07;86(4):2067-78. 2011-12-07 [PMID: 22156524] (Binding Assay, Human)	Binding Assay	Human
Sensi M, Catani M, Castellano G Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J. Invest. Dermatol., 2011-07-28;131(12):2448-57. 2011-07-28 [PMID: 21796150] (Bioassay, Human)	Bioassay	Human
Show All 12 Publications. Collapse Publications.

Array 154-AL

• Axl Antibodies
• Axl Antibody Pair
• Axl Lysate
• Axl Proteins
• Axl ELISAs
• Axl Proteins and Enzymes