Recombinant Canine IFN-gamma Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature canine IFN-gamma exists as a noncovalently linked homodimer of 20‑25 kDa variably glycosylated subunits (3). It shares 79%‑88% amino acid sequence identity with bovine, equine, and feline IFN-gamma , 62%‑73% with human, porcine, and rhesus IFN-gamma , and 40%-47% with cotton rat, mouse, and rat IFN-gamma . IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta  subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).

We have publications tested in 1 confirmed species: Canine.

We have publications tested in 2 applications: Bioassay, ELISA (Standard).

Showing Publications 1 - 10 of 10.

Publications using 781-CG	Applications	Species
Lyu, Q;Veldhuizen, EJA;Ludwig, IS;Rutten, VPMG;van Eden, W;Sijts, AJAM;Broere, F; Characterization of polarization states of canine monocyte derived macrophages PloS one 2023-11-08 [PMID: 37939066] (Bioassay, Canine)	Bioassay	Canine
M Pelst, C Höbart, H de Rooster, B Devriendt, E Cox Immortalised canine buccal epithelial cells' CXCL8 secretion is affected by allergen extracts, Toll-like receptor ligands, IL-17A and calcitriol Veterinary research, 2022-09-13;53(1):72. 2022-09-13 [PMID: 36100942] (Bioassay, Canine)	Bioassay	Canine
JW Choi, SS Withers, H Chang, JA Spanier, VL De La Trin, H Panesar, BT Fife, R Sciammas, EE Sparger, PF Moore, MS Kent, RB Rebhun, SJ McSorley Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function PLoS ONE, 2020-07-02;15(7):e0235518. 2020-07-02 [PMID: 32614928] (Bioassay, Canine)	Bioassay	Canine
KA Lahey, NJ Ronaghan, J Shang, SP Dion, A Désilets, R Leduc, WK MacNaughto Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function PLoS ONE, 2017-07-03;12(7):e0180259. 2017-07-03 [PMID: 28671992] (Bioassay, Canine)	Bioassay	Canine
C Westenfeld, A Gooch, Z Hu, J Ahlstrom, P Zhang Durable Control of Autoimmune Diabetes in Mice Achieved by Intraperitoneal Transplantation of Neo-Islets, Three-Dimensional Aggregates of Allogeneic Islet and Mesenchymal Stem Cells Stem Cells Transl Med, 2017-05-03;0(0):. 2017-05-03 [PMID: 28467694] (Bioassay, Canine)	Bioassay	Canine
Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Via Multiple Distinct Biochemical Pathways Stem Cells Dev., 2016-12-22;0(0):. 2016-12-22 [PMID: 27842458] (Bioassay, Canine)	Bioassay	Canine
Recombinant Forms of Leishmania amazonensis Excreted/Secreted Promastigote Surface Antigen (PSA) Induce Protective Immune Responses in Dogs PLoS Negl Trop Dis, 2016-05-25;10(5):e0004614. 2016-05-25 [PMID: 27223609] (ELISA (Standard), Canine)	ELISA (Standard)	Canine
Lemesre JL, Holzmuller P, Goncalves RB, Bourdoiseau G, Hugnet C, Cavaleyra M, Papierok G Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial. Vaccine, 2007-03-15;25(21):4223-34. 2007-03-15 [PMID: 17395339] (ELISA (Standard))	ELISA (Standard)
Fujiwara RT, Loukas A, Mendez S, Williamson AL, Bueno LL, Wang Y, Samuel A, Zhan B, Bottazzi ME, Hotez PJ, Bethony JM Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs. Vaccine, 2005-08-15;24(4):501-9. 2005-08-15 [PMID: 16140437] (ELISA (Standard))	ELISA (Standard)
Lemesre JL, Holzmuller P, Cavaleyra M, Goncalves RB, Hottin G, Papierok G Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes. Vaccine, 2005-04-22;23(22):2825-40. 2005-04-22 [PMID: 15780731] (ELISA (Standard))	ELISA (Standard)

Array 781-CG

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes