Recombinant Bovine IFN-gamma Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature bovine IFN-gamma exists as a noncovalently linked homodimer of 20‑25 kDa variably glycosylated subunits (3). It shares 78%‑80% amino acid (aa) sequence identity with canine, feline, equine, and porcine IFN-gamma and 42%‑59% with cotton rat, human, mouse, rat, and rhesus IFN-gamma . IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).

We have publications tested in 3 confirmed species: Human, Bovine, Ovine.

We have publications tested in 2 applications: Bioassay, ELISA Developmet.

Showing Publications 1 - 5 of 5.

Publications using 2300-BG	Applications	Species
SJ Gilbert, EJ Blain, DJ Mason Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms Biochemistry and Biophysics Reports, 2022-09-07;32(0):101323. 2022-09-07 [PMID: 36105611] (Bioassay, Bovine)	Bioassay	Bovine
RG Schaut, MV Palmer, PM Boggiatto, IT Kudva, CL Loving, VK Sharma Mucosal IFN&gamma production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle Scientific Reports, 2021-05-07;11(1):9769. 2021-05-07 [PMID: 33963240] (Bioassay, Human)	Bioassay	Human
W Wheat, L Chow, V Rozo, J Herman, K Still Broo, A Colbath, R Hunter, S Dow Non-specific protection from respiratory tract infections in cattle generated by intranasal administration of an innate immune stimulant PLoS ONE, 2020-06-25;15(6):e0235422. 2020-06-25 [PMID: 32584899] (Bioassay, Bovine)	Bioassay	Bovine
O Huaman, J Bahamonde, B Cahuascanc, M Jervis, J Palomino, CG Torres, OA Peralta Immunomodulatory and immunogenic properties of mesenchymal stem cells derived from bovine fetal bone marrow and adipose tissue Res. Vet. Sci., 2019-03-21;124(0):212-222. 2019-03-21 [PMID: 30925336] (Bioassay, Bovine)	Bioassay	Bovine
A Abdalmula, LM Dooley, C Kaufman, EA Washington, JV House, BA Blacklaws, P Ghosh, S Itescu, SR Bailey, WG Kimpton Immunoselected STRO-3(+) mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis Stem Cell Res Ther, 2017-02-07;8(1):22. 2017-02-07 [PMID: 28173831] (ELISA Developmet, Ovine)	ELISA Developmet	Ovine

Array 2300-BG

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes