Rat TIMP-1 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

We have publications tested in 1 confirmed species: Rat.

Showing Publications 1 - 8 of 8.

Publications using RTM100	Applications	Species
Somsura, R;Kamkajon, K;Chaimongkolnukul, K;Chantip, S;Teerapornpuntakit, J;Wongdee, K;Kamonsutthipaijit, N;Tangtrongsup, S;Panupinthu, N;Tiyasatkulkovit, W;Charoenphandhu, N; Tissue-specific expression of senescence biomarkers in spontaneously hypertensive rats: evidence of premature aging in hypertension PeerJ 2023-10-19 [PMID: 37872946] (Rat)		Rat
AH Kadam, K Kandasamy, T Buss, B Cederstrom, C Yang, S Narayanapi, J Rodriguez, MD Levin, J Koziol, B Olenyuk, Z Borok, A Chrastina, JE Schnitzer Targeting caveolae to pump bispecific antibody to TGF-beta into diseased lungs enables ultra-low dose therapeutic efficacy PLoS ONE, 2022-11-22;17(11):e0276462. 2022-11-22 [PMID: 36413536] (Rat)		Rat
TR Goesch, NA Wilson, W Zeng, BM Verhoven, W Zhong, MM Coumbe Git, WE Fahl Suppression of Inflammation-Associated Kidney Damage Post-Transplant Using the New PrC-210 Free Radical Scavenger in Rats Biomolecules, 2021-07-19;11(7):. 2021-07-19 [PMID: 34356678] (Rat)		Rat
Y Yuan, H Naito, K Kitamori, S Hashimoto, T Asano, T Nakajima The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension PLoS ONE, 2020-12-14;15(12):e0243846. 2020-12-14 [PMID: 33315911] (Rat)		Rat
NM El-Lakkany, WH El-Maadawy, SH Seif El-Di, OA Hammam, SH Mohamed, SM Ezzat, MM Safar, S Saleh Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis Asian Pac J Trop Med, 2017-05-17;10(5):444-453. 2017-05-17 [PMID: 28647181] (Rat)		Rat
Tinnes , Stefanie, Ringwald , Julia, Haas , Carola A TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy. FASEB J, 2013-03-14;27(7):2542-52. 2013-03-14 [PMID: 23493620] (Rat)		Rat
Cong M, Liu T, Wang P, Fan X, Yang A, Bai Y, Peng Z, Wu P, Tong X, Chen J, Li H, Cong R, Tang S, Wang B, Jia J, You H Antifibrotic effects of a recombinant adeno-associated virus carrying small interfering RNA targeting TIMP-1 in rat liver fibrosis. Am J Pathol, 2013-03-07;182(5):1607-16. 2013-03-07 [PMID: 23474083] (Rat)		Rat
Akool el-S, Doller A, Muller R, Gutwein P, Xin C, Huwiler A, Pfeilschifter J, Eberhardt W Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway. J. Biol. Chem., 2005-09-23;280(47):39403-16. 2005-09-23 [PMID: 16183640] (Rat)		Rat

Array RTM100

• TIMP-1 Antibodies
• TIMP-1 Antibody Pair
• TIMP-1 ELISA Kits
• TIMP-1 Lysate
• TIMP-1 Protein
• TIMP-1 Proteins and Enzymes
• TIMP-1 ELISAs