PXR/NR1I2 Antibody (H0502) [Unconjugated] Summary
Immunogen |
Recombinant human PXR/NR1I2 aa 1-78 |
Specificity |
This antibody specifically recognizes human PXR2 but not human PXR1. The
antibody epitope lies in amino acids 1-40. Not yet tested in other species. |
Source |
N/A |
Isotype |
IgG2a |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
NR1I2 |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Direct ELISA
- Western Blot
|
Packaging, Storage & Formulations
Storage |
This antibody is stable for greater than six months when stored at -20 °C in a
manual defrost freezer or at -70 °C. Upon thawing, the antibody can be
stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid
repeated freeze-thaw cycles. |
Buffer |
A liquid formulation in physiologic saline with 0.1% NaN3. |
Preservative |
0.1% Sodium Azide |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for PXR/NR1I2 Antibody (H0502) [Unconjugated]
Background
Pregnane X Receptor 2 (PXR2; also known as PAR2, SXR and NR1I2) is a
46 kDa member of the NR1 subfamily of the Nuclear Hormone Receptor
family. It is one of at least seven splice forms from a single gene. Two basic
forms exist, a 434 amino acid (aa) PXR1 form and a 473 aa PXR2 form. The
PXR2 isoform has a 39 aa extension at the N-terminus and results from the
use of an alternate exon 1. PXR forms heterodimers with Retinoid X Receptor
(RXR) and is activated by pregnanolone, progesterone, xenobiotics, and
endobiotics.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Secondary Antibodies
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