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PXR/NR1I2 Antibody (H0502) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clone
H0502
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Suitable Sample Type
23005

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PXR/NR1I2 Antibody (H0502) [Unconjugated] Summary

Immunogen
Recombinant human PXR/NR1I2
aa 1-78
Specificity
This antibody specifically recognizes human PXR2 but not human PXR1. The antibody epitope lies in amino acids 1-40. Not yet tested in other species.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
NR1I2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Direct ELISA
  • Western Blot

Packaging, Storage & Formulations

Storage
This antibody is stable for greater than six months when stored at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Buffer
A liquid formulation in physiologic saline with 0.1% NaN3.
Preservative
0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PXR/NR1I2 Antibody (H0502) [Unconjugated]

  • BXR
  • NR1I2
  • nuclear receptor subfamily 1 group I member 2
  • nuclear receptor subfamily 1, group I, member 2
  • ONR1
  • Orphan nuclear receptor PAR1
  • Orphan nuclear receptor PXR
  • PAR
  • PAR1
  • PAR2
  • Pregnane X receptor
  • PRR
  • PXR
  • PXRPARq
  • SAR
  • Steroid and xenobiotic receptor
  • SXR
  • SXRBXR

Background

Pregnane X Receptor 2 (PXR2; also known as PAR2, SXR and NR1I2) is a 46 kDa member of the NR1 subfamily of the Nuclear Hormone Receptor family. It is one of at least seven splice forms from a single gene. Two basic forms exist, a 434 amino acid (aa) PXR1 form and a 473 aa PXR2 form. The PXR2 isoform has a 39 aa extension at the N-terminus and results from the use of an alternate exon 1. PXR forms heterodimers with Retinoid X Receptor (RXR) and is activated by pregnanolone, progesterone, xenobiotics, and endobiotics.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NR1I2