Calcium-sensing R/CaSR Antibody (5C10, ADD) - BSA Free

The calcium sensing receptor (CaSR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CaSR is similar to the 7-transmembrane-domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Porcine.

We have publications tested in 7 applications: ELISA, FLOW, ICC/IF, IF/IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using NB120-19347	Applications	Species
Sherman BE, Calderon E, Price RS Characterizing the Role of Calcium Sensing Receptor in the Progression of Obesity-Mediated Aggressive Prostate Cancer Phenotype Nutrition and cancer 2023-02-14 [PMID: 36786422]
Nery F, Siranosian J, Rosales I et al. Impaired kidney structure and function in spinal muscular atrophy Neurol Genet 2019-10-01 [PMID: 31517062] (IHC-P, Human)	IHC-P	Human
Bachinger D, Egli H, Goosmann MM et al. Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear Cell Tissue Res. 2019-07-23 [PMID: 31338584] (IHC-P, Mouse)	IHC-P	Mouse
Luchsinger LL, Strikoudis A, Danzl NM et al. Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro Cell Stem Cell 2019-05-31 [PMID: 31178255] (FLOW, Mouse, Human)	FLOW	Mouse, Human
Issa H, Henaut L, Abdallah JB et al. Activation of the calcium-sensing receptor in human valvular interstitial cells promotes calcification J. Mol. Cell. Cardiol. 2019-02-12 [PMID: 30769016] (WB, IHC-Fr, Human)	WB, IHC-Fr	Human
Frees S, Breuksch I, Haber T et al. Calcium-sensing receptor (CaSR) promotes development of bone metastasis in renal cell carcinoma. Oncotarget. [PMID: 29644008] (FLOW, WB, Human)	FLOW, WB	Human
Boudot C, Henaut L, Thiem U et al. Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation Oncotarget 2017-08-22 [PMID: 28915604] (WB, Mouse)	WB	Mouse
Dai XQ, Perez PL, Soria G et al. External Ca(2+) regulates polycystin-2 (TRPP2) cation currents in LLC-PK1 renal epithelial cells. Exp. Cell Res. 2016-11-09 [PMID: 27836810] (Porcine)		Porcine
Koh J, Hogue JA, Sosa JA. A Novel Ex Vivo Method for Visualizing Live-Cell Calcium Response Behavior in Intact Human Tumors. PLoS One 2016-08-18 [PMID: 27537691] (ICC/IF)	ICC/IF
Koh J, Hogue JA, Wang Y et al. Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism. J. Cell. Mol. Med. 2015-12-05 [PMID: 26638194] (ICC/IF, Human)	ICC/IF	Human
Shilo V, Ben-Dov IZ, Nechama M et al. Parathyroid-specific deletion of dicer-dependent microRNAs abrogates the response of the parathyroid to acute and chronic hypocalcemia and uremia FASEB J. 2015-06-08 [PMID: 26054367] (IHC-P, Mouse)	IHC-P	Mouse
Szalat A, Shahar M, Shpitzen S et al. Calcium-sensing receptor sequencing in 21 patients with idiopathic or familial parathyroid disorder: pitfalls and characterization of a novel I32 V loss-of-function mutation. Endocrine. 2014-08-05 [PMID: 25091521]
Olauson H, Lindberg K, Amin R et al. Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion. PLoS Genet 2013-12-01 [PMID: 24348262] (ICC/IF, IHC-P, Mouse)	ICC/IF, IHC-P	Mouse
Walter S, Baruch A, Dong J et al. Pharmacology of AMG 416 (Velcalcetide), a novel peptide agonist of the calcium-sensing receptor, for the treatment of secondary hyperparathyroidism in hemodialysis patients. J Pharmacol Exp Ther. 2013-08-01 [PMID: 23674604]
Toka HR, Al-Romaih K, Koshy JM et al. Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol. 2012-11-01 [PMID: 22997254]
Galitzer H, Ben-Dov IZ, Silver J et al. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int. 2010-02-01 [PMID: 20016468] (IHC-P, Rat)	IHC-P	Rat
Meir T, Levi R, Lieben L et al. Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology. Am J Physiol Renal Physiol;297(5):F1192-8. 2009-11-01 [PMID: 19692484] (IHC-P, Mouse)	IHC-P	Mouse
Alam MU et al. Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res;81(2):260-8. 2009-02-01 [PMID: 18852253] (WB, IF/IHC)	WB, IF/IHC
Weston AH et al. Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231. Circ Res;97(4):391-8. 2005-08-19 [PMID: 16037572] (IF/IHC)	IF/IHC
Goldsmith PK et al. Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. J Biol Chem. 274(16):11303-9. 1999-04-16 [PMID: 10196220] (WB)	WB
Goldsmith PK et al. Monoclonal antibodies against synthetic peptides corresponding to the extracellular domain of the human Ca2+ receptor: characterization and use in studying concanavalin A inhibition. J Bone Miner Res;12(11):1780-8. 1997-11-01 [PMID: 9383682] (FLOW, ELISA)	FLOW, ELISA
Show All 21 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	ICC	Human	02/25/2022	View Summary Application Immunocytochemistry Sample Tested primary astrocytes Species Human Lot CMHK01-2

Array NB120-19347

• Calcium-sensing R/CaSR Antibodies
• Calcium-sensing R/CaSR ELISA Kits
• Calcium-sensing R/CaSR Lysate
• Calcium-sensing R/CaSR Proteins
• Calcium-sensing R/CaSR Proteins and Enzyme