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Podoplanin Antibody (8.1.1) [DyLight 405]

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Product Details

Summary
Reactivity Mu, Hu(-)Species Glossary
Applications WB, Flow, ICC/IF, IHC, IP, MS, CyTOF-ready
Clone
8.1.1
Clonality
Monoclonal
Host
Golden Syrian Hamster
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB600-1015AF350
Alexa Fluor 405
NB600-1015AF405
Alexa Fluor 488
NB600-1015AF488
Alexa Fluor 532
NB600-1015AF532
Alexa Fluor 594
NB600-1015AF594
Alexa Fluor 647
NB600-1015AF647
Alexa Fluor 700
NB600-1015AF700
Alexa Fluor 750
NB600-1015AF750
Allophycocyanin
NB600-1015APC
Biotin
NB600-1015B
CoraFluor 1
NB600-1015CL1
DyLight 350
NB600-1015UV
DyLight 488
NB600-1015G
DyLight 550
NB600-1015R
DyLight 594
NB600-1015DL594
DyLight 650
NB600-1015C
DyLight 680
NB600-1015FR
DyLight 755
NB600-1015IR
FITC
NB600-1015F
HRP
NB600-1015H
Janelia Fluor 525
NB600-1015JF525
Janelia Fluor 549
NB600-1015JF549
Janelia Fluor 646
NB600-1015JF646
Janelia Fluor 669
NB600-1015JF669
PE
NB600-1015PE
PerCP
NB600-1015PCP
Unconjugated
NB600-1015
mFluor Violet 450 SE
NB600-1015MFV450
mFluor Violet 500 SE
NB600-1015MFV500
mFluor Violet 610 SE
NB600-1015MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB600-1015
BSA Free
NB600-1015SS
BSA Free
NB600-1015
Azide and BSA Free
NBP2-80916
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Podoplanin Antibody (8.1.1) [DyLight 405] Summary

Immunogen
Murine thymic stromal cell lines
Localization
Membrane; Single-pass type I membrane protein.
Marker
Lymphatic Endothelium Marker
Isotype
IgG
Clonality
Monoclonal
Host
Golden Syrian Hamster
Gene
PDPN
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Electron Microscopy
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Does not cross-react with human.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Podoplanin Antibody (8.1.1) [DyLight 405]

  • 36-KD
  • Aggrus
  • Gp36
  • Gp38
  • GP40
  • HT1A-1
  • hT1alpha-1
  • hT1alpha-2
  • lung type I cell membrane associated glycoprotein
  • lung type-I cell membrane-associated glycoprotein (T1A-2)
  • OTS 8
  • OTS8
  • PA2.26 antigen
  • PDPN
  • Podoplanin
  • RANDAM-2
  • T1A
  • T1A-2
  • T1-alpha

Background

Podoplanin (PDPN, Gp38 or Ots8) belongs to family of type-1 transmembrane sialomucin-like glycoproteins and is expressed in various tissues such as keratinocytes, synovial fibroblasts, lymphatic endothelial cells and cancerous cells. Originally identified in glomerular podocytes, PDPN is now considered as one of the most reliable markers for immunodetection of lymphatic endothelium. Its expression has been documented in benign/malignant cancers such as thymoma, osteosarcoma, laryngeal squamous cell carcinoma, odontogenic tumors as well as in CIS (carcinoma in situ)/ SCC (squamous cell carcinoma) of the oral mucosa. PDPN implicates in cellular migration and/or actin cytoskeleton organization, induction of platelet aggregation and is essential to lung cell proliferation as well as alveolus formation postpartum. PDPN expression is up-regulated by pro-inflammatory factors, such as IFN-gamma, TGF-beta, TNF-alpha and IL-1beta; and its mucin-type character has been shown to be associated with its pathophysiological functions including polarized migration of lymphatic endothelial cells as well as in invasion of cancer. PDPN knockout mice show embryonic lethality with respiratory failure and defective development of lymphoid follicles, germinal centers in spleen and lymph node remnants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PDPN