PLGF Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Placenta Growth Factor (PlGF) is a member of the Vascular Endothelial Growth Factor (VEGF) family of growth factors. PlGF and VEGF share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. All eight cysteine residues involved in intra- and inter-chain disulfides are conserved among these growth factors. In their PDGF-like regions, VEGF and PlGF also share approximately 53% amino acid sequence similarity. The gene for PlGF has been mapped to chromosome 14. As a result of alternative splicing, at least two PlGF mRNAs encoding monomeric PlGF precursors containing 149 and 170 amino acid residues have been described. The expression of PlGF is not widespread, but has been detected in human umbilical vein endothelial cells, placenta, choriocarcinoma cell lines, and in renal cell carcinoma associated with angiogenesis. The PlGF proteins bind with high-affinity to Flt-1, but not to Flk-1/KDR.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Guinea Pig.

We have publications tested in 3 applications: IHC, Neutralization, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF-264-PB	Applications	Species
JM Murrieta-C, RN Gutiérrez-, HM El-Shorafa, T Groten, S Rodríguez-, ME Cancino-Di, JC Cancino-Di, RR Favaro, UR Markert, DM Morales-Pr Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells International Journal of Molecular Sciences, 2020-12-30;22(1):. 2020-12-30 [PMID: 33396613] (Western Blot, Human)	Western Blot	Human
Jussara S. Michaloski, Alexandre R. Redondo, Leila S. Magalhães, Caio C. Cambui, Ricardo J. Giordano Discovery of pan-VEGF inhibitory peptides directed to the extracellular ligand-binding domains of the VEGF receptors Science Advances 2016-10-28 [PMID: 27819042]
Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model. Angiogenesis, 2010-10-16;13(4):337-47. 2010-10-16 [PMID: 20953695] (Neutralization, Human)	Neutralization	Human
Matsunaga Y, Yamazaki Y, Suzuki H, Morita T VEGF-A and VEGF-F evoke distinct changes in vascular ultrastructure. Biochem. Biophys. Res. Commun., 2009-01-04;379(4):872-5. 2009-01-04 [PMID: 19126400] (IHC, Guinea Pig)	IHC	Guinea Pig
Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops. Int. J. Cancer, 2003-05-01;104(5):603-10. 2003-05-01 [PMID: 12594815] (Western Blot, Human)	Western Blot	Human
Zhou Y, 2019, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. 2002-04-01;160(4):1405-23. 2002-04-01 [PMID: 11943725] (IHC, Human)	IHC	Human

Array AF-264-PB

• PLGF Antibodies
• PLGF ELISA Kit
• PLGF Proteins
• PLGF Proteins and Enzymes
• PLGF ELISAs