Peroxiredoxin 1 Antibody (477609) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human Peroxiredoxin1 (Prx-1, also known as Thioredoxin peroxidase 2) is a 22 kDa antioxidant enzyme that belongs to the typical 2-Cys class of the THP/ahpC family of proteins. The molecule is 199 amino acids (aa) in length and has two catalytic cysteines, one at Cys52 and a second at Cys173. Prx-1 is an obligate homodimer. In its inactive state, Prx-1 is apparently noncovalently associated. Upon peroxide binding to Cys52 of subunit 1, the Cys173 of subunit 2 interacts with Cys52 of subunit 1 to complete the antioxidation, generating a disulfide bond between Cys52 and Cys173. Subsequent reduction restores the subunits to the basal state. There are apparently two additional isoforms; one shows a premature truncation after aa 171, while the second shows a deletion of aa 21‑121. Human Prx-1 is 96% aa identical to mouse Prx-1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using MAB3488	Applications	Species
Niklas Müller, Timothy Warwick, Kurt Noack, Pedro Felipe Malacarne, Arthur J. L. Cooper, Norbert Weissmann et al. Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells Antioxidants (Basel) 2022-02-21 [PMID: 35204316]

Array MAB3488

• Peroxiredoxin 1 Antibodies
• Peroxiredoxin 1 Lysates
• Peroxiredoxin 1 Proteins