PBR Antibody

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: ICC/IF, IF/IHC, IHC, IHC-P, IP, WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using NB100-41398	Applications	Species
Nutma E, Gebro E, Marzin MC et al. Activated microglia do not increase 18 kDa translocator protein (TSPO) expression in the multiple sclerosis brain Glia 2021-06-19 [PMID: 34145928]
Cohen AS, Li J, Hight MR et al. TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions Clinical Cancer Research 2020-11-15 [PMID: 32933996] (IHC)	IHC
Hieu Tran V, Park H, Park J et al. Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamide Bioorg. Med. Chem. 2019-07-19 [PMID: 31353076] (IF/IHC, Rat, Human)	IF/IHC	Rat, Human
Buck JR, McKinley ET, Fu A et al. Preclinical TSPO Ligand PET to Visualize Human Glioma Xenotransplants: A Preliminary Study. PLoS ONE. 2015-10-31 [PMID: 26517124] (IHC-P, Human)	IHC-P	Human
Zhou T, Frabutt DA, Moremen KW, Zheng YH et al. ERManI is required for HIV-1 envelope glycoprotein degradation via endoplasmic reticulum-associated protein degradation pathway J. Biol. Chem. 2015-07-23 [PMID: 26205822] (WB, Human)	WB	Human
Zhou T, Dang Y, Zheng YH. The Mitochondrial Translocator Protein, TSPO, Inhibits HIV-1 Envelope Glycoprotein Biosynthesis via the Endoplasmic Reticulum-Associated Protein Degradation Pathway. J. Virol. 2014-03-01 [PMID: 24403586] (WB, Human)	WB	Human
Wu X, Gallo KA. The 18-kDa Translocator Protein (TSPO) Disrupts Mammary Epithelial Morphogenesis and Promotes Breast Cancer Cell Migration. PLoS One. 2013-08-14 [PMID: 23967175] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Joo, HK et al. Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1 FEBS Lett 2012-01-01 [PMID: 22616995] (WB, Human)	WB	Human
Papadopoulos V, Baraldi M, Guilarte TR et al. Translocator protein (18kDa): new nomenclature for the peripheral-typebenzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 2006-08-01 [PMID: 16822554]
Robb J Characterisation of immunometabolic responses in astrocytes Thesis 2020-01-01 (IP)	IP
Chang CW, Chiu CH, Lin MH et al. GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression EJNMMI research 2021-03-16 [PMID: 33725191] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Nutma E, Fancy N, Marzin M et al. Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases Research Square 2022-03-23
Fafalios A, Akhavan A, Parwani AV et al. Translocator Protein Blockade Reduces Prostate Tumor Growth. Clin Cancer Res;15(19):6177-6184. 2009-01-01 [PMID: 19789311]
Show All 13 Publications. Collapse Publications.

Array NB100-41398

• PBR Antibodies
• PBR Lysate
• PBR Proteins