p97/VCP Antibody

Valosin-containing protein (VCP) is a multifunctional protein that is proposed to be involved in vesicle transport and fusion for protein trafficking, 26S proteasome function in ubiquitin-based degradation pathways, and the assembly of peroxisomes. Mutations in the human VCP gene have been associated with diseases such as inclusion body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD). VCP can inhibit apoptosis and may play a role in tumorigenesis. VCP is also known as, Transitional Endoplasmic Reticulum ATPase, TER ATPase, TERA, 15S Mg (2+)-ATPase p97subunit, IBMPFD, Inclusion Body Myopathy associated with Paget Disease of Bone and Frontotemporal Dementia, MGC8560; MGC131997; MGC148092.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-1557	Applications	Species
Chroma K, Skrott Z, Gursky J et al. A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment Cell death & disease 2022-03-04 [PMID: 35246527] (WB, Human)	WB	Human
Skrott Z, Mistrik M, Andersen KK et al. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature 2017-12-14 [PMID: 29211715] (WB, Human)	WB	Human
Liu Y, Testa JS, Philip R et al. A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation. PLoS ONE;6(9). 2011-01-01 [PMID: 21969857]
Tcherpakov M, Delaunay A, Toth J et al. Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). J Biol Chem 2009-05-01 [PMID: 19269966]
Dong M, Bridges JP, Apsley K et al. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell 2008-06-01 [PMID: 18400946]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Luiz Alexandre Magno	WB	Rat	10/17/2018	View Summary Application Western Blot Sample Tested PC12 cell whole cell lysate. Species Rat Lot A1 Comments Comments It works very well at 1:1,000 dilution when loading gels with 30 ug of protein extracts (PC12 cells in my case).

Array NB100-1557

• p97/VCP Antibodies
• p97/VCP Lysate
• p97/VCP Proteins