p40/deltaNp63 Antibody (P40/4396R) [DyLight 550]

Recombinant Monoclonal Antibody

Recombinant fragment (around aa1-100) of human p40/deltaNp63 protein (exact sequence is proprietary) (Uniprot: Q9H3D4 )

Nucleus

Squamous, Basal & Myoepithelial Cell Marker

p40 antibody (antibody recognizing Np63 only) is an isoform of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential a role that may be recapitulated in tumors derived from these cells. p40 is normally expressed in the basal or progenitor cell layer of stratified epithelia (eg. squamous, urothelial, bronchial), basal cells of some glandular epithelia (eg. prostate), as well as myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma. p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.

IgG Kappa

Monoclonal

Rabbit

TP63

Protein A purified

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Optimal dilution of this antibody should be experimentally determined.