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p40/deltaNp63 Antibody (P40/4396R) [Alexa Fluor® 594]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, IHC
Clone
P40/4396R
Clonality
Monoclonal
Host
Rabbit
Conjugate
Alexa Fluor 594

Order Details

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p40/deltaNp63 Antibody (P40/4396R) [Alexa Fluor® 594] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant fragment (around aa1-100) of human p40/deltaNp63 protein (exact sequence is proprietary) (Uniprot: Q9H3D4 )
Localization
Nucleus
Marker
Squamous, Basal & Myoepithelial Cell Marker
Specificity
p40 antibody (antibody recognizing Np63 only) is an isoform of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential a role that may be recapitulated in tumors derived from these cells. p40 is normally expressed in the basal or progenitor cell layer of stratified epithelia (eg. squamous, urothelial, bronchial), basal cells of some glandular epithelia (eg. prostate), as well as myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma. p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
TP63
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for p40/deltaNp63 Antibody (P40/4396R) [Alexa Fluor® 594]

  • AIS
  • amplified in squamous cell carcinoma
  • B(p51A)
  • B(p51B)
  • Chronic ulcerative stomatitis protein
  • EEC3
  • Keratinocyte transcription factor KET
  • KET
  • LMS
  • OFC8
  • p53CP
  • SHFM4
  • TP53CP
  • TP53L
  • TP63
  • TP73L
  • Transformation-related protein 63
  • tumor protein p53-competing protein

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional p40/deltaNp63 Products

Array NBP3-14050AF594

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Bioinformatics

Gene Symbol TP63