NBR1 Antibody (6B11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: EM, ICC/IF, WB.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using H00004077-M01	Applications	Species
Calcagni' A, Staiano L, Zampelli N et al. Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation Nature communications 2023-07-03 [PMID: 37400440] (WB)	WB
E Turco, A Savova, F Gere, L Ferrari, J Romanov, M Schuschnig, S Martens Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation Nature Communications, 2021-09-01;12(1):5212. 2021-09-01 [PMID: 34471133]
Chang HC, Tao RN, Tan CT et al. The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore Autophagy 2021-03-30 [PMID: 33783314]
Chong T, Hao-Chun C, Qiling Z et al. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. EMBO Rep. 2021-01-04 [PMID: 33393215]
Monaco A, Maffia V, Sorrentino N et al. The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Mol Ther. 2020-02-12 [PMID: 32087148]
Park S, Zuber C, Roth J Selective autophagy of cytosolic protein aggregates involves ribosome-free rough endoplasmic reticulum Histochem. Cell Biol. 2019-11-12 [PMID: 31720797]
Riccio V, Demers N, Hua R et al. Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy. J Cell Biol. 2019 Jan 30 [PMID: 30700497]
Cai J, Pires KM, Ferhat M et al. Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk. Cell Rep 2018-11-13 [PMID: 30428342]
Jiang L, Hara-Kuge S, Yamashita SI, Fujiki Y. Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II. Genes Cells. 2014-10-31 [PMID: 25358256]
Dowdle WE, Nyfeler B, Nagel J et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014-10-19 [PMID: 25327288]
Nicot AS, Lo Verso F, Ratti F et al. Phosphorylation of NBR1 by GSK3 modulates protein aggregation. Autophagy. 2014-06-01 [PMID: 24879152]
Park S, Jang I, Zuber C et al. ERADication of EDEM1 occurs by selective autophagy and requires deglycosylation by cytoplasmic peptide N-glycanase. Histochem. Cell Biol. 2014-03-25 [PMID: 24664425] (WB, ICC/IF, EM, Human)	WB, ICC/IF, EM	Human
Micsenyi MC, Sikora J, Stephney G et al. Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal disease. J Neurosci 2013-06-26 [PMID: 23804102] (WB, Mouse)	WB	Mouse
Rue L, Lopez-Soop G, Gelpi E et al. Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease. Neurobiol Dis. 2013-01-04 [PMID: 23295856]
Deosaran E, Larsen KB, Hua R et al. NBR1 acts as an autophagy receptor for peroxisomes. J Cell Sci. 2012-12-13 [PMID: 23239026]
Wong E, Bejarano E, Rakshit M et al. Molecular determinants of selective clearance of protein inclusions by autophagy. Nat Commun. 2012-12-04 [PMID: 23212369]
Mardakheh FK, Auciello G, Dafforn TR et al. Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation. Mol Cell Biol;30(24):5672-85. 2010-12-01 [PMID: 20937771]
Mardakheh FK, Yekezare M, Machesky LM, et al. Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. J Cell Biol. 2009-10-12 [PMID: 19822672]
Show All 18 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	Simple Western	Human	12/05/2019	View Summary Application Simple Western Sample Tested THP-1 macrophage lysate Species Human Lot J9231-6B11

Array H00004077-M01

• NBR1 Antibodies
• NBR1 Lysates
• NBR1 Proteins