Nanog Antibody (5A10) - BSA Free

Nanog is a multidomain homeobox transcription factor that functions to maintain the undifferentiated state of pluripotent stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF, Stat3 and BMP. When Nanog expression is downregulated, cell differentiation can proceed. Proteins that regulate Nanog expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 7 of 7.

Publications using NBP1-04320	Applications	Species
Gong W, Sun B, Sun H et al. Nodal signaling activates the Smad2/3 pathway to regulate stem cell-like properties in breast cancer cells. Am J Cancer Res. 2017-04-12 [PMID: 28401007] (WB, Human)	WB	Human
Koh SP, On N, Brasch HD et al. Embryonic Stem Cell-like Population in Dupuytren's Disease. Plast Reconstr Surg Glob Open. 2016-11-01 [PMID: 27975007] (IF/IHC, Human)	IF/IHC	Human
Yu HH, Featherston T, Tan ST et al. Characterization of Cancer Stem Cells in Moderately Differentiated Buccal Mucosal Squamous Cell Carcinoma. Front Surg. 2016-08-17 [PMID: 27532037] (IF/IHC, Human)	IF/IHC	Human
Kumar B, Yadav A, Lang JC et al. Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog. Genes Cancer. 2015-03-01 [PMID: 26000099] (WB, Human) Details: Nanog antibody was used for WB application on lysates of human head and neck squamous cell carcinoma cell line CAL27 and UD-SCC-2 cell line as well as their cisplatin-resistant variants namely CAL27-CisR and UD-SCC-2-CisR respectively (Figure 3E-F). WB also performed on CAL27-CisR and UD-SCC-2-CisR cell that were subjected or not to HDAC1 / HDAC2 knocked down using siRNA (Figure 4A-B), and on CAL27-CisR and UD-SCC-2-CisR cells treated or not with Suberoylanilide Hydroxamic Acid /SAHA, an HDAC inhibitor (Figure 6C-D).	WB	Human
Lin F, Prichard J, Bitting AK et al. Geisinger Immunohistochemical Antibodies and Staining Protocols Handbook of Practical Immunohistochemistry. 2015-01-01 (IHC-P, Human)	IHC-P	Human
Yadav A, Kumar B, Teknos TN, Kumar P. Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer. Oncotarget. [PMID: 28978005] (WB, Human)	WB	Human
Moretti A, Bellin M, Jung CB et al. Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. FASEB J 2009-01-01 [PMID: 19850773]

Array NBP1-04320

• Nanog Antibodies
• Nanog Lysate
• Nanog Proteins