Myosin Heavy Chain Antibody (MF20) [Fluorescein]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Skeletal muscle Myosin or myosin II is the motor protein that generates force to drive muscle contraction. It is a 520 kDa hexamer comprised of two heavy chains and four light chains. Myosin heavy chain is 220 kDa in size and consists of a long coiled-coil domain tail that mediates dimerization of the two heavy chains and a globular head region that mediates ATP-dependent sliding of actin filaments. Myosin heavy chain can be proteolytically cleaved to produce heavy meromyosin, which includes the S1 motor domain (head region) and first third of the coiled coil domain, and light meromyosin, which includes the C-terminal two thirds of the coiled coil domain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC, IHC, IHC-Fr.

Showing Publications 1 - 6 of 6.

Publications using IC4470F	Applications	Species
K Awad, N Ahuja, M Fiedler, S Peper, Z Wang, P Aswath, M Brotto, V Varanasi Ionic Silicon Protects Oxidative Damage and Promotes Skeletal Muscle Cell Regeneration International Journal of Molecular Sciences, 2021-01-06;22(2):. 2021-01-06 [PMID: 33419056] (ICC, Mouse)	ICC	Mouse
Jian Huang, Kun Wang, Lora A. Shiflett, Leticia Brotto, Lynda F. Bonewald, Michael J. Wacker et al. Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells Cell Cycle 12/17/2019 [PMID: 31735119]
C Mo, Z Wang, L Bonewald, M Brotto Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways Int J Mol Sci, 2019-09-04;20(18):. 2019-09-04 [PMID: 31487817] (ICC, Mouse)	ICC	Mouse
LR Fiedler, K Chapman, M Xie, E Maifoshie, M Jenkins, PA Golforoush, M Bellahcene, M Noseda, D Faust, A Jarvis, G Newton, MA Paiva, M Harada, DJ Stuckey, W Song, J Habib, P Narasimham, R Aqil, D Sanmugalin, R Yan, L Pavanello, M Sano, SC Wang, RD Sampson, S Kanayagana, GE Taffet, LH Michael, ML Entman, TH Tan, SE Harding, CMR Low, C Tralau-Ste, T Perrior, MD Schneider MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In�Vivo Cell Stem Cell, 2019-03-07;0(0):. 2019-03-07 [PMID: 30853557] (IHC, Mouse)	IHC	Mouse
H Ohtsubo, Y Sato, T Suzuki, W Mizunoya, M Nakamura, R Tatsumi, Y Ikeuchi APOBEC2 negatively regulates myoblast differentiation in muscle regeneration Int. J. Biochem. Cell Biol, 2017-02-12;85(0):91-101. 2017-02-12 [PMID: 28215905] (ICC, Mouse)	ICC	Mouse
I Toral-Ojed, G Aldanondo, J Lasa-Elgar, H Lasa-Ferná, R Fernández-, A López de M, A Vallejo-Il Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle Expert Rev Mol Med, 2016-04-08;18(0):e7. 2016-04-08 [PMID: 27055500] (IHC-Fr, Human)	IHC-Fr	Human

Array IC4470F

• Myosin Heavy Chain Antibodies