Myosin Heavy Chain Antibody (MF20) [Allophycocyanin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Skeletal muscle Myosin or Myosin II is the motor protein that generates force to drive muscle contraction. It is a 520 kDa hexamer comprised of two heavy chains and four light chains. Myosin heavy chain is 220 kDa in size and consists of a long coiled-coil domain tail that mediates dimerization of the two heavy chains and a globular head region that mediates ATP-dependent sliding of Actin filaments. Myosin heavy chain can be proteolytically cleaved to produce heavy Meromyosin, which includes the S1 motor domain (head region) and first third of the coiled-coil domain, and light Meromyosin, which includes the C-terminal two thirds of the coiled-coil domain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using IC4470A	Applications	Species
Gesa Witt, Oliver Keminer, Jennifer Leu, Rashmi Tandon, Ina Meiser, Anne Willing et al. An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds Cell Biology and Toxicology 2021-04-01 [PMID: 32564278]

Array IC4470A

• Myosin Heavy Chain Antibodies