Mouse TIMP-1 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 9 of 9.

Publications using DY980	Applications	Species
MC Morrison, E Gart, WV Duyvenvoor, J Snabel, MJ Nielsen, DJ Leeming, A Menke, R Kleemann Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr-/-.Leiden Mice International Journal of Molecular Sciences, 2022-02-19;23(4):. 2022-02-19 [PMID: 35216439] (Mouse)		Mouse
CL Huang, LL Xiao, M Xu, J Li, SF Li, CS Zhu, YL Lin, R He, X Li Chemerin deficiency regulates adipogenesis is depot different through TIMP1 Genes & diseases, 2020-04-09;8(5):698-708. 2020-04-09 [PMID: 34291141] (Mouse)		Mouse
B Burger, CMC Kühl, T Candreva, RDS Cardoso, JR Silva, BG Castelucci, SR Consonni, HL Fisk, PC Calder, MAR Vinolo, HG Rodrigues Oral administration of EPA-rich oil impairs collagen reorganization due to elevated production of IL-10 during skin wound healing in mice Sci Rep, 2019-06-24;9(1):9119. 2019-06-24 [PMID: 31235718] (Mouse)		Mouse
J Vandooren, W Swinnen, E Ugarte-Ber, L Boon, D Dorst, E Martens, G Opdenakker Endotoxemia shifts neutrophils with TIMP-free gelatinase B/ MMP-9 from bone marrow to periphery and induces systematic upregulation of TIMP-1 Haematologica, 2017-08-03;0(0):. 2017-08-03 [PMID: 28775117] (Mouse)		Mouse
Weber S, Wetzel S, Prox J, Lehmann T, Schneppenheim J, Donners M, Saftig P Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10). Biochem Biophys Res Commun, 2013-11-15;442(3):234-41. 2013-11-15 [PMID: 24239882] (Mouse)		Mouse
Koscso B, Csoka B, Kokai E, Nemeth Z, Pacher P, Virag L, Leibovich S, Hasko G Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol, 2013-08-06;94(6):1309-15. 2013-08-06 [PMID: 23922379] (Mouse)		Mouse
Pitteri SJ, Kelly-Spratt KS, Gurley KE Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression. Cancer Res., 2011-06-08;71(15):5090-100. 2011-06-08 [PMID: 21653680] (Mouse)		Mouse
Kang S, Park EJ, Joe Y, Seo E, Park MK, Seo SY, Chung HY, Yoo YH, Kim DK, Lee HJ Systemic delivery of TNF-related apoptosis-inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and prevents type 1 diabetes in nonobese diabetic mice. Endocrinology, 2010-11-03;151(12):5638-46. 2010-11-03 [PMID: 21047948] (Mouse)		Mouse
Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J. Clin. Invest., 2007-12-01;117(12):3786-99. 2007-12-01 [PMID: 17992263] (Mouse)		Mouse

Array DY980

• TIMP-1 Antibodies
• TIMP-1 Antibody Pair
• TIMP-1 ELISA Kit
• TIMP-1 Lysate
• TIMP-1 Protein
• TIMP-1 Proteins and Enzymes
• TIMP-1 ELISAs