Mouse IL-21 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-21 (Interleukin-21) is member of the family of cytokines that utilize the common gamma chain as a receptor subunit. This subunit is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex of the common gamma chain and the IL-21-specific IL-21 R. IL-21 supports Tfh cell development, immunoglobulin affinity maturation, plasma cell differentiation, B cell memory responses, and the migration of dendritic cells to draining lymph nodes. It costimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. In addition, IL-21 suppresses cutaneous hypersensitivity reactions by limiting allergen-specific IgE production and mast cell degranulation.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 10 of 34. Show All 34 Publications. Collapse Publications.

Publications using DY594	Applications	Species
An, S;Oh, J;Shon, HJ;Song, J;Choi, YS;Kim, D; Co-adjuvanting Nod2-stimulating bacteria with a TLR7 agonist elicits potent protective immunity against respiratory virus infection International journal of antimicrobial agents 2024-10-28 [PMID: 39477030] (Mouse)		Mouse
Morgaenko, K;Arneja, A;Ball, AG;Putelo, AM;Munson, JM;Rutkowski, MR;Pompano, RR; Ex vivo model of breast cancer cell invasion in live lymph node tissue bioRxiv : the preprint server for biology 2024-07-22 [PMID: 39091774] (Mouse)		Mouse
Landoni, E;Woodcock, MG;Barragan, G;Casirati, G;Cinella, V;Stucchi, S;Flick, LM;Withers, TA;Hudson, H;Casorati, G;Dellabona, P;Genovese, P;Savoldo, B;Metelitsa, LS;Dotti, G; IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity Nature communications 2024-01-02 [PMID: 38167707] (Mouse)		Mouse
YW Liu, SH Fu, MW Chien, CY Hsu, MH Lin, JL Dong, RJ Lu, YJ Lee, PY Chen, CH Wang, HK Sytwu Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit JCI Insight, 2022-06-08;0(0):. 2022-06-08 [PMID: 35503415] (Mouse)		Mouse
BS Cox, K Alharshawi, I Mena-Palom, WP Lafuse, ME Ariza EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities JCI Insight, 2022-06-08;7(11):. 2022-06-08 [PMID: 35482424] (Mouse)		Mouse
M Arabpour, C Lebrero-Fe, K Schön, A Strömberg, V Börjesson, K Lahl, M Ballegeer, X Saelens, D Angeletti, W Agace, N Lycke ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection Mucosal Immunology, 2022-04-13;0(0):. 2022-04-13 [PMID: 35418673] (Mouse)		Mouse
SG Jang, J Lee, SM Hong, YS Song, MJ Kim, SK Kwok, ML Cho, SH Park Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3 Journal of Translational Medicine, 2021-02-25;19(1):86. 2021-02-25 [PMID: 33632240] (Mouse)		Mouse
W Zhou, Y Yang, C Mei, P Dong, S Mu, H Wu, Y Zhou, Y Zheng, F Guo, JQ Yang Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection Cells, 2019-10-16;8(10):. 2019-10-16 [PMID: 31623153] (Mouse)		Mouse
JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation J. Leukoc. Biol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31260596] (Mouse)		Mouse
R Spolski, EE West, P Li, S Veenbergen, S Yung, M Kazemian, J Oh, ZX Yu, AF Freeman, SM Holland, PM Murphy, WJ Leonard IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus Elife, 2019-04-16;8(0):. 2019-04-16 [PMID: 30969166] (Mouse)		Mouse
A Ariyaratne, EK Szabo, J Bowron, CAM Finney Increases in helminth-induced IL-21 protein levels disappear upon sample freezing Cytokine, 2018-04-21;108(0):179-181. 2018-04-21 [PMID: 29684754] (Mouse)		Mouse
B Li, X Wang, IY Choi, YC Wang, S Liu, AT Pham, H Moon, DJ Smith, DS Rao, MP Boldin, L Yang miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity J. Clin. Invest., 2017-09-05;0(0):. 2017-09-05 [PMID: 28872459] (Mouse)		Mouse
L Tan, S Han, S Ding, W Xiao, Y Ding, L Qian, C Wang, W Gong Chitosan nanoparticle-based delivery of fused NKG2D-IL-21 gene suppresses colon cancer growth in mice Int J Nanomedicine, 2017-04-13;12(0):3095-3107. 2017-04-13 [PMID: 28450784] (Mouse)		Mouse
Michel van Gelder Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer Breast Cancer Res. Treat, 2016-12-03;0(0):. 2016-12-03 [PMID: 27915436] (Mouse)		Mouse
Immune signatures of protective spleen memory CD8 T cells Sci Rep, 2016-11-24;6(0):37651. 2016-11-24 [PMID: 27883012] (Mouse)		Mouse
ER? in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity J Immunol, 2016-05-13;0(0):. 2016-05-13 [PMID: 27183630] (Mouse)		Mouse
Nagashima , Hiroyuki, Okuyama , Yuko, Asao , Atsuko, Kawabe , Takeshi, Yamaki , Satoshi, Nakano , Hiroyasu, Croft , Michael, Ishii , Naoto, So , Takanori The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol, 2014-03-30;15(5):449-56. 2014-03-30 [PMID: 24681564] (Mouse)		Mouse
Tatano Y, Shimizu T, Tomioka H Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization. Sci Rep, 2014-02-20;4(0):4146. 2014-02-20 [PMID: 24553452] (Mouse)		Mouse
Ubel C, Sopel N, Graser A, Hildner K, Reinhardt C, Zimmermann T, Rieker R, Maier A, Neurath M, Murphy K, Finotto S The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma. J Allergy Clin Immunol, 2013-11-28;133(1):198-206.e1-9. 2013-11-28 [PMID: 24290279] (Mouse)		Mouse
Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol, 2013-11-13;7(4):786-801. 2013-11-13 [PMID: 24220301] (Mouse)		Mouse
Slight S, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko B, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart T, Randall T, Khader S CXCR5(+) T helper cells mediate protective immunity against tuberculosis. J Clin Invest, 2013-01-02;123(2):712-26. 2013-01-02 [PMID: 23281399] (Mouse)		Mouse
El-Behi M, Ciric B, Dai H The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 2011-04-24;12(6):568-75. 2011-04-24 [PMID: 21516111] (Mouse)		Mouse
Sarra M, Caruso R, Cupi ML, Monteleone I, Stolfi C, Campione E, Diluvio L, Mazzotta A, Botti E, Chimenti S, Costanzo A, MacDonald TT, Pallone F, Monteleone G IL-21 Promotes Skin Recruitment of CD4+ Cells and Drives IFN-{gamma}-Dependent Epidermal Hyperplasia. J. Immunol., 2011-03-25;186(9):5435-42. 2011-03-25 [PMID: 21441456] (Mouse)		Mouse
Takeuchi H, Yokota A, Ohoka Y, Kagechika H, Kato C, Song SY, Iwata M Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins. J. Immunol., 2010-09-29;185(9):5289-99. 2010-09-29 [PMID: 20881191] (Mouse)		Mouse
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J. Exp. Med., 2010-07-05;207(8):1617-24. 2010-07-05 [PMID: 20603312] (Mouse)		Mouse
Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature, 2009-07-05;460(7253):405-9. 2009-07-05 [PMID: 19578362] (Mouse)		Mouse
Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med., 2009-01-12;206(1):69-78. 2009-01-12 [PMID: 19139170] (Mouse)		Mouse
Kim-Schulze S, Kim HS, Fan Q, Kim DW, Kaufman HL Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment. Mol. Ther., 2008-11-25;17(2):380-8. 2008-11-25 [PMID: 19034262] (Mouse)		Mouse
Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity, 2008-07-03;29(1):127-37. 2008-07-03 [PMID: 18602282] (Mouse)		Mouse
Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat. Immunol., 2008-05-30;9(7):769-76. 2008-05-30 [PMID: 18516037] (Mouse)		Mouse
Wei L, Laurence A, Elias KM, O'Shea JJ IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J. Biol. Chem., 2007-09-20;282(48):34605-10. 2007-09-20 [PMID: 17884812] (Mouse)		Mouse
Kumano M, Hara I, Furukawa J, Oniki S, Nagai H, Miyake H, Fujisawa M Interleukin-21 activates cytotoxic T lymphocytes and natural killer cells to generate antitumor response in mouse renal cell carcinoma. J. Urol., 2007-08-16;178(4):1504-9. 2007-08-16 [PMID: 17707061] (Mouse)		Mouse
Coquet JM, Kyparissoudis K, Pellicci DG, Besra G, Berzins SP, Smyth MJ, Godfrey DI IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J. Immunol., 2007-03-01;178(5):2827-34. 2007-03-01 [PMID: 17312126] (Mouse)		Mouse
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet., 2007-02-04;39(3):329-37. 2007-02-04 [PMID: 17277778] (Mouse)		Mouse
Show All 34 Publications. Collapse Publications.

Array DY594

• IL-21 Antibodies
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• IL-21 Lysate
• IL-21 Proteins
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• IL-21 ELISAs