Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Mouse FGF acidic/FGF1 DuoSet ELISA, 5 Plate
AFGF
alpha
alpha-ECGF
beta-ECGF
ECGF
ECGFB
ECGF-betaAcidic fibroblast growth factor
endothelial cell growth factor, beta
FGF acidic
FGF-1
FGFABeta-endothelial cell growth factor
FGF-alpha
fibroblast growth factor 1 (acidic)
GLIO703
HBGF1
HBGF-1
heparin-binding growth factor 1
Background
FGF acidic, also known as FGF-1, ECGF, and HBGF-1, is a secreted mitogen that stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. FGF acidic is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF acidic with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Internalized FGF acidic can translocate to the cytosol and to the nucleus. Intracellular FGF acidic functions as a survival factor by inhibiting p53 activity and proapoptotic signaling.