MMR/CD206/Mannose Receptor Antibody

The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail.The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines such as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The antibody 15-2 prevents binding of glycoproteins including t-PA to MR. Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Porcine, Primate.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-P, Immunohistochemistry, Immunohistochemistry-Paraffin.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using NBP1-90020	Applications	Species
Li, Xiaonan, X Facile One-Pot Synthesis of Meteor Hammer-like Au-MnOx Nanozymes with Spiky Surface for NIR-II Light-Enhanced Bacterial Elimination Chemistry of Materials 2022-11-22
Liu, C;Zhou, C;Xia, W;Zhou, Y;Qiu, Y;Weng, J;Zhou, Q;Chen, W;Wang, YN;Lee, HH;Wang, SC;Kuang, M;Yu, D;Ren, N;Hung, MC; Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma Nature communications 2024-02-02 [PMID: 38307859]
McDonald SJ, Bullard BM, VanderVeen BN et al. Emodin reduces surgical wounding-accelerated tumor growth and metastasis via macrophage suppression in a murine triple-negative breast cancer model Physiological reports 2023-10-01 [PMID: 37821408] (IHC-P, Mouse) Details: 1:100 dilution	IHC-P	Mouse
Dravid A, Dhanabalan K, Naskar S et al. Sustained release Resolvin D1 liposomes are effective in the treatment of osteoarthritis in obese mice bioRxiv 2023-01-23 [PMID: 36773024]
Kim JH, Kim GH, Ryu YM et al. Clinical implications of the tumor microenvironment using multiplexed immunohistochemistry in patients with advanced or metastatic renal cell carcinoma treated with nivolumab plus ipilimumab Frontiers in Oncology 2022-09-27 [PMID: 36237314] (Immunohistochemistry)	Immunohistochemistry
Dravid AA, M Dhanabalan K, Agarwal S, Agarwal R. Resolvin D1-loaded nanoliposomes promote M2 macrophage polarization and are effective in the treatment of osteoarthritis Bioengineering & Translational Medicine 2022-05-01 [PMID: 35600665]
Xue L, Deng T, Guo R et al. A Composite Hydrogel Containing Mesoporous Silica Nanoparticles Loaded With Artemisia argyi Extract for Improving Chronic Wound Healing Frontiers in Bioengineering and Biotechnology 2022-03-25 [PMID: 35402406]
Kim HD, Kim SY, Kim J et al. Dynamic increase of M2 macrophages is associated with disease progression of colorectal cancers following cetuximab-based treatment Scientific reports 2022-01-31 [PMID: 35102212] (ICC/IF, Human)	ICC/IF	Human
Mou KJ, Shen KF, Li YL et al. Adenosine A2A Receptor in Bone Marrow-Derived Cells Mediated Macrophages M2 Polarization via PPAR gamma-P65 Pathway in Chronic Hypoperfusion Situation Frontiers in aging neuroscience 2022-01-03 [PMID: 35046793]
Saadati F, Moritz J, Berner J et al. Patient-Derived Human Basal and Cutaneous Squamous Cell Carcinoma Tissues Display Apoptosis and Immunomodulation following Gas Plasma Exposure with a Certified Argon Jet International Journal of Molecular Sciences 2021-10-23 [PMID: 34768877]
Lombardo KA, Obradovic A, Singh AK et al. BCG invokes superior STING-mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer The Journal of Pathology 2022-02-01 [PMID: 34731491] (Immunohistochemistry, Immunohistochemistry-Paraffin)	Immunohistochemistry, Immunohistochemistry-Paraffin
Roy R, Zayas J, Mohamed MF et al. IL-10 Dysregulation Underlies Chemokine Insufficiency, Delayed Macrophage Response, and Impaired Healing in Diabetic Wounds Journal of Investigative Dermatology 2022-03-01 [PMID: 34517005]
Davis T, Conradie D, Shridas P et al. Serum amyloid A promotes inflammation-associated damage and tumourigenesis in a mouse model of colitis-associated cancer Cellular and Molecular Gastroenterology and Hepatology 2021-07-01 [PMID: 34217896] (IF/IHC, Mouse)	IF/IHC	Mouse
Sun G, Cao Y, Qian C et Al. Romo1 is involved in the immune response of glioblastoma by regulating the function of macrophages Aging (Albany NY) 2020-01-16 [PMID: 31945745] (ICC/IF, Mouse)	ICC/IF	Mouse
HD Dawson, JK Lunney Porcine cluster of differentiation (CD) markers 2018 update Res. Vet. Sci., 2018-02-22;118(0):199-246. 2018-02-22 [PMID: 29518710]
Siani F, Greco R, Levandis G et al. Influence of Estrogen Modulation on Glia Activation in a Murine Model of Parkinson's Disease. Front Neurosci. 2017-06-16 [PMID: 28620274] (ICC/IF, Mouse)	ICC/IF	Mouse
Loegl J, Hiden U, Nussbaumer E et al. Hofbauer cells of M2a, M2b and M2c polarization may regulate feto-placental angiogenesis. Reproduction 2016-11-01 [PMID: 27534571] (IF/IHC, Human)	IF/IHC	Human
Pincus SH, Bhaskaran M, Brey RN III et al. Clinical and Pathological Findings Associated with Aerosol Exposure of Macaques to Ricin Toxin. Toxins (Basel) 2015-06-09 [PMID: 26067369] (IF/IHC, Primate)	IF/IHC	Primate
Cai Y, Sugimoto C, Arainga M et al. In vivo characterization of alveolar and interstitial lung macrophages in rhesus macaques: Implications for understanding lung disease in humans. J Immunol 2014-03-15 [PMID: 24534529] (ICC/IF, Primate)	ICC/IF	Primate
Eirin A, Zhang X, Zhu XY et al. Renal vein cytokine release as an index of renal parenchymal inflammation in chronic experimental renal artery stenosis. Nephrol Dial Transplant 2014-02-01 [PMID: 24097799] (IF/IHC, Porcine)	IF/IHC	Porcine
Eirin A, Williams BJ, Ebrahimi B et al. Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension. J Hypertens 2014-01-01 [PMID: 24048008] (IF/IHC, Porcine)	IF/IHC	Porcine
Show All 21 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Flow	Mouse	08/09/2019	View Summary Application Flow Cytometry Sample Tested Liver Species Mouse Lot K119215

Array NBP1-90020

• MMR/CD206/Mannose Receptor Antibodies
• MMR/CD206/Mannose Receptor ELISA Kits
• MMR/CD206/Mannose Receptor Proteins
• MMR/CD206/Mannose Receptor Proteins and Enzymes