MMP-17 Antibody (823511) [Unconjugated] Summary
| Immunogen |
Mouse myeloma cell line NS0-derived recombinant human MMP-17
Pro42-Ala534
Accession # Q9ULZ9 |
| Specificity |
Detects human MMP-17 in direct ELISAs.
In direct ELISAs, no cross-reactivity
with recombinant human MMP-24 is observed. |
| Source |
N/A |
| Isotype |
IgG2a |
| Clonality |
Monoclonal |
| Host |
Mouse |
| Gene |
MMP17 |
| Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
| Endotoxin Note |
<0.10 EU per 1 μg of the antibody by the LAL method. |
| Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Packaging, Storage & Formulations
| Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
| Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Preservative |
No Preservative |
| Reconstitution Instructions |
Sterile PBS to a final concentration of 0.5 mg/mL. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for MMP-17 Antibody (823511) [Unconjugated]
Background
Matrix metalloproteinase 17 (MMP‑17) is a zinc metalloproteinase that is an integral membrane protein (1). It belongs to the membrane‑type MMP (MT‑MMP) subfamily, and is also known as MT4‑MMP. It is associated with the cell membrane by a glycosylphosphatidylinositol (GPI) anchor (1). It has the potential to function as a pro‑tumor necrosis factor‑ alpha (TNF‑ alpha ) convertase (2). Unlike MMP‑14 (MT1‑MMP), it is a poor activator of pro‑MMP‑2. MMP‑17 is relatively poor at digesting components of the extracellular matrix but does cleave fibrinogen and fibrin (2). MMP‑17 is known to activate the aggrecanase ADAMTS‑4 through proteolysis (3). MMP‑17 is expressed in many tissues with the highest levels seen in the brain, colon, ovary, testis, and kidney papilla (4). It has been detected in several human cancers, including gliomas, prostate carcinomas, and breast carcinomas (5).
- Itoh, Y. et al. (1999) J. Biol. Chem. 274:34260.
- English, W. R. et al. (2000) J. Biol. Chem. 275:14046.
- Gao, G. et al. (2004) J. Biol. Chem. 279:10042.
- Srichai, M. B. et al. (2011) PLoS ONE 6:e17099.
- Sohail, A. et al. (2008) Cancer Metastasis Rev. 27:289.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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