Name: MICA/B Antibody (159207) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB13001
Price: 459 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Flow, IHC, B/N, CyTOF-ready
Clone	159207
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB13001U-100UG

Alexa Fluor 405 FAB13001V-100UG

Alexa Fluor 488 FAB13001G-025

Alexa Fluor 488 FAB13001G-100

Alexa Fluor 532 FAB13001X

Alexa Fluor 594 FAB13001T-100UG

Alexa Fluor 647 FAB13001R-100UG

Alexa Fluor 700 FAB13001N-100

Alexa Fluor 700 FAB13001N-025

Alexa Fluor 750 FAB13001S-100UG

Allophycocyanin FAB13001A-025

Allophycocyanin FAB13001A-100

Allophycocyanin/Cy7 FAB13001APCCY7

Biotin FAB13001B

CoraFluor 1 FAB13001CL1

DyLight 350 FAB13001D

DyLight 405 FAB13001E

DyLight 488 FAB13001K

DyLight 550 FAB13001L

DyLight 594 FAB13001M

DyLight 650 FAB13001W

DyLight 680 FAB13001Y

DyLight 755 FAB13001Z

FITC FAB13001F

HRP FAB13001H

Janelia Fluor 525 FAB13001JF525

Janelia Fluor 549 FAB13001I

Janelia Fluor 585 FAB13001JF585

Janelia Fluor 635 FAB13001JF635

Janelia Fluor 646 FAB13001J

Janelia Fluor 669 FAB13001JF669

PE/Atto594 FAB13001PEATT594

PE/Cy5.5 FAB13001PECY55

PE/Cy7 FAB13001PECY7

PerCP FAB13001C

Phycoerythrin FAB13001P-100

Phycoerythrin FAB13001P-025

mFluor Violet 450 SE FAB13001MFV450

mFluor Violet 500 SE FAB13001MFV500

mFluor Violet 610 SE FAB13001MFV610

Catalog# & Formulation	Size	Price
Carrier Free MAB13001-SP

Carrier Free FAB13001S-100UG

Carrier Free FAB13001T-100UG

Carrier Free FAB13001U-100UG

Carrier Free FAB13001V-100UG

Carrier Free MAB13001-500

Carrier Free FAB13001N-025

Carrier Free FAB13001P-025

Carrier Free FAB13001N-100

Carrier Free FAB13001G-100

Carrier Free FAB13001G-025

Carrier Free FAB13001A-100

Carrier Free FAB13001A-025

Carrier Free FAB13001P-100

Carrier Free FAB13001R-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB13001U-100UG
Alexa Fluor 405	FAB13001V-100UG
Alexa Fluor 488	FAB13001G-025
Alexa Fluor 488	FAB13001G-100
Alexa Fluor 532	FAB13001X
Alexa Fluor 594	FAB13001T-100UG
Alexa Fluor 647	FAB13001R-100UG
Alexa Fluor 700	FAB13001N-100
Alexa Fluor 700	FAB13001N-025
Alexa Fluor 750	FAB13001S-100UG
Allophycocyanin	FAB13001A-025
Allophycocyanin	FAB13001A-100
Allophycocyanin/Cy7	FAB13001APCCY7
Biotin	FAB13001B
CoraFluor 1	FAB13001CL1
DyLight 350	FAB13001D
DyLight 405	FAB13001E
DyLight 488	FAB13001K
DyLight 550	FAB13001L
DyLight 594	FAB13001M
DyLight 650	FAB13001W
DyLight 680	FAB13001Y
DyLight 755	FAB13001Z
FITC	FAB13001F
HRP	FAB13001H
Janelia Fluor 525	FAB13001JF525
Janelia Fluor 549	FAB13001I
Janelia Fluor 585	FAB13001JF585
Janelia Fluor 635	FAB13001JF635
Janelia Fluor 646	FAB13001J
Janelia Fluor 669	FAB13001JF669
PE/Atto594	FAB13001PEATT594
PE/Cy5.5	FAB13001PECY55
PE/Cy7	FAB13001PECY7
PerCP	FAB13001C
Phycoerythrin	FAB13001P-100
Phycoerythrin	FAB13001P-025
mFluor Violet 450 SE	FAB13001MFV450
mFluor Violet 500 SE	FAB13001MFV500
mFluor Violet 610 SE	FAB13001MFV610

MICA/B Antibody (159207) [Unconjugated]

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MICA/B Antibody (159207) [Unconjugated] Summary

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Publications for MICA/B Antibody (MAB13001)(18)

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Bioinformatics

Immunogen	BaF3 mouse pro-B cell line transfected with human MICA Accession # Q29983
Specificity	Detects human MICA/B in direct ELISAs.
Source	N/A
Isotype	IgG2a
Clonality	Monoclonal
Host	Mouse
Gene	MICA
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB13001	Applications	Species
Yi Zhang, Feifei Luo, Kuiran Dong Soluble NKG2D ligands impair CD8+ T cell antitumor function dependent of NKG2D downregulation in neuroblastoma Oncology Letters 5/24/2023 [PMID: 37274476]
JD Lewicky, AL Martel, NL Fraleigh, E Picard, L Mousavifar, A Nakamura, F Diaz-Mitom, R Roy, HT Le Exploiting the DNA Damaging Activity of Liposomal Low Dose Cytarabine for Cancer Immunotherapy Pharmaceutics, 2022-12-03;14(12):. 2022-12-03 [PMID: 36559204] (Flow Cytometry, Human)	Flow Cytometry	Human
S Belkahla, JM Brualla, A Fayd'herbe, P Falvo, N Allende-Ve, M Constantin, AUH Khan, L Coenon, C Alexia, G Mitola, P Massa, S Orecchioni, F Bertolini, W Mnif, J Hernandez, A Anel, M Villalba The metabolism of cells regulates their sensitivity to NK cells depending on p53 status Scientific Reports, 2022-02-25;12(1):3234. 2022-02-25 [PMID: 35217717] (Flow Cytometry, Human)	Flow Cytometry	Human
N Allende-Ve, J Marco Brua, P Falvo, C Alexia, M Constantin, AF de Maudave, L Coenon, D Gitenay, G Mitola, P Massa, S Orecchioni, F Bertolini, I Marzo, A Anel, M Villalba Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1) Scientific Reports, 2022-01-25;12(1):1341. 2022-01-25 [PMID: 35079096] (Flow Cytometry, Neutralization, Human)	Flow Cytometry, Neutralization	Human
R Domenis, A Cifù, D Marinò, M Fabris, KR Niazi, P Soon-Shion, F Curcio Toll-like Receptor-4 Activation Boosts the Immunosuppressive Properties of Tumor Cells-derived Exosomes Sci Rep, 2019-06-11;9(1):8457. 2019-06-11 [PMID: 31186484] (Neutralization, Human)	Neutralization	Human
DP Muñoz, SM Yannone, A Daemen, Y Sun, F Vakar-Lope, M Kawahara, AM Freund, F Rodier, JD Wu, PY Desprez, DH Raulet, PS Nelson, LJ van 't Vee, J Campisi, JP Coppé Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging JCI Insight, 2019-06-11;5(0):. 6/11/2019 [PMID: 31184599]
CF Huang, SC Wang, WT Chang, ML Yeh, CI Huang, ZY Lin, SC Chen, WL Chuang, JF Huang, CY Dai, YL Chen, ML Yu Lower protein expression levels of MHC class I chain-related gene A in hepatocellular carcinoma are at high risk of recurrence after surgical resection Sci Rep, 2018-10-25;8(1):15821. 2018-10-25 [PMID: 30361527] (IHC, Human)	IHC	Human
Maria Giovanna Desimio, Erica Giuliani, Angelo Salvatore Ferraro, Gaspare Adorno, Margherita Doria In Vitro Exposure to Prostratin but Not Bryostatin-1 Improves Natural Killer Cell Functions Including Killing of CD4+ T Cells Harboring Reactivated Human Immunodeficiency Virus Frontiers in Immunology 6/29/2018 [PMID: 30008723]
Stephan Klöss, Nicole Chambron, Tanja Gardlowski, Sandra Weil, Joachim Koch, Ruth Esser et al. Cetuximab Reconstitutes Pro-Inflammatory Cytokine Secretions and Tumor-Infiltrating Capabilities of sMICA-Inhibited NK Cells in HNSCC Tumor Spheroids Frontiers in Immunology 11/2/2015 [PMID: 26579120]
HYUNKEUN SONG, YEONYE KIM, GABIN PARK, YEONG-SEOK KIM, SEONGHAN KIM, HYUN-KYUNG LEE et al. Transforming growth factor-beta 1 regulates human renal proximal tubular epithelial cell susceptibility to natural killer cells via modulation of the NKG2D ligands International Journal of Molecular Medicine 10/1/2015 [PMID: 26311146]
Cox S, Laza-Briviesca R, Pearson H, Soria B, Gibson D, Gomez S, Madrigal J, Saudemont A Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity. Eur J Immunol, 2015-06-09;45(8):2324-34. 2015-06-09 [PMID: 25991034] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Jorgensen MM, Baek R, Varming K. Potentials and capabilities of the Extracellular Vesicle (EV) Array. J Extracell Vesicles 1/1/2015 [PMID: 25862471]
Kim H, Bose S, Meyer K, Ray R Hepatitis C virus impairs natural killer cell-mediated augmentation of complement synthesis. J Virol, 2013-12-18;88(5):2564-71. 2013-12-18 [PMID: 24352446] (Western Blot, Human)	Western Blot	Human
Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog., 2012-01-12;8(1):e1002486. 2012-01-12 [PMID: 22253598] (Flow Cytometry, Human)	Flow Cytometry	Human
Hedlund M, Nagaeva O, Kargl D, Baranov V, Mincheva-Nilsson L Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells. PLoS ONE, 2011-02-25;6(2):e16899. 2011-02-25 [PMID: 21364924] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
Perier A, Fregni G, Wittnebel S, Gad S, Allard M, Gervois N, Escudier B, Azzarone B, Caignard A Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma. Oncogene, 2011-01-24;30(23):2622-32. 2011-01-24 [PMID: 21258414] (Flow Cytometry, Human)	Flow Cytometry	Human
Roda-Navarro P, Vales-Gomez M, Chisholm SE, Reyburn HT Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc. Natl. Acad. Sci. U.S.A., 2006-07-18;103(30):11258-63. 2006-07-18 [PMID: 16849432] (ICC, Human)	ICC	Human
Skov S, Pedersen MT, Andresen L, Straten PT, Woetmann A, Odum N Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B. Cancer Res., 2005-12-01;65(23):11136-45. 2005-12-01 [PMID: 16322264] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 18 Publications. Collapse Publications.

Gene Symbol	MICA
Uniprot	Q29983()