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Mer Antibody (125518) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready, ELISA, ELISA(Cap), ELISA(Det), KO
Clone
125518
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB8912U-100UG
Alexa Fluor 405
FAB8912V-100UG
Alexa Fluor 488
FAB8912G
Alexa Fluor 532
FAB8912X
Alexa Fluor 594
FAB8912T-100UG
Alexa Fluor 647
FAB8912R-100UG
Alexa Fluor 700
FAB8912N
Alexa Fluor 750
FAB8912S-100UG
Allophycocyanin
FAB8912A
Allophycocyanin/Cy7
FAB8912APCCY7
Biotin
FAB8912B
CoraFluor 1
FAB8912CL1
DyLight 350
FAB8912D
DyLight 405
FAB8912E
DyLight 488
FAB8912K
DyLight 550
FAB8912L
DyLight 594
FAB8912M
DyLight 650
FAB8912W
DyLight 680
FAB8912Y
DyLight 755
FAB8912Z
FITC
FAB8912F
HRP
FAB8912H
Janelia Fluor 525
FAB8912JF525
Janelia Fluor 549
FAB8912I
Janelia Fluor 585
FAB8912JF585
Janelia Fluor 635
FAB8912JF635
Janelia Fluor 669
FAB8912JF669
PE/Atto594
FAB8912PEATT594
PE/Cy5.5
FAB8912PECY55
PE/Cy7
FAB8912PECY7
PerCP
FAB8912C
Phycoerythrin
FAB8912P
Unconjugated
MAB8912-100
mFluor Violet 450 SE
FAB8912MFV450
mFluor Violet 500 SE
FAB8912MFV500
mFluor Violet 610 SE
FAB8912MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB8912-100
Carrier Free
FAB8912P
Carrier Free
FAB8912A
Carrier Free
FAB8912G
Carrier Free
FAB8912N
Carrier Free
MAB8912-SP
Carrier Free
MAB8912-100
Carrier Free
MAB8912-500
Carrier Free
FAB8912V-100UG
Carrier Free
FAB8912U-100UG
Carrier Free
FAB8912T-100UG
Carrier Free
FAB8912S-100UG
Carrier Free
FAB8912R-100UG
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Mer Antibody (125518) [Janelia Fluor® 646] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Mer
Met1-Ala499
Accession # AAB60430
Specificity
Detects human Mer in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Axl, rhDtk, or recombinant mouse Mer is observed.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
MERTK
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
  • Flow Cytometry
  • Knockout Validated
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Mer Antibody (125518) [Janelia Fluor® 646]

  • c-Eyk
  • c-mer proto-oncogene tyrosine kinase
  • C-mer
  • EC 2.7.10
  • EC 2.7.10.1
  • MER receptor tyrosine kinase
  • Mer
  • MerTK
  • MGC133349
  • Receptor tyrosine kinase MerTK
  • RP38Proto-oncogene c-Mer
  • STK kinase
  • tyrosine-protein kinase Mer

Background

MerTK (c-mer, Nyk, Eyk) is a tyrosine kinase that belongs to a family of transmembrane receptors (1). MerTk has been implicated in reversible cell growth arrest, survival, proliferation and cell adhesion. Growth arrest specific protein 6 (Gas6) is an activating ligand for MerTK (2-3). MerTK is required for clearance of apoptotic cells by mononuclear phagocytes in mice; with its absence resulting in progressive lupus like autoimmunity (4). Defects in MERTK are a cause of retinitis pigmentosa (RP) (5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MERTK